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The map label for this gene is msrA [H]

Identifier: 157962069

GI number: 157962069

Start: 2726486

End: 2726965

Strand: Direct

Name: msrA [H]

Synonym: Spea_2248

Alternate gene names: 157962069

Gene position: 2726486-2726965 (Clockwise)

Preceding gene: 157962062

Following gene: 157962071

Centisome position: 52.69

GC content: 44.58

Gene sequence:

>480_bases
ATGGCATTGGCAACATTCGGCGCAGGGTGTTTTTGGGGAGTTGAATACTTTTTCAGAGAAGTTGAAGGTGTCATTGACTG
TACGTGCGGATATATGGGCGGCAAAGACAGCTACACCCGCTACGCAGAAGTCAAAACGGGTACCACTGGTCACGCAGAGG
TTGTGCAAGTGGAGTACGACCCTAACATTGTGAGTTACCAACGCTTACTGGAGGTTTTTTGGCAGAACCACAATCCCACC
ACATTGAATCAACAAGGTGGTGATATTGGTAGCCAGTATAGAAGCGCTGTTTTTTTTCATGATAAACAACAGAAGCATCA
GGCCGAAGTTGCCAAATTAGCACTCATCAAAAGTGCAAAATGGGGCTCACGCCAGATAGTCACTGAAGTTGTACCTTGTC
AGCAGTTTCATCAGGCTGAAGCGTATCATCAAGATTACTTAGCTAAAAATGAATTGCCTAGCTGTCATATCAGTTATTAA

Upstream 100 bases:

>100_bases
CTATGCGCTTTTTTACTTGCGCAAACCTAAAAAATAAAACAAGATAAAGACATCTAGCCATCCAAACGGCTATTTGTGAT
AATTTATTGAGGAGACAGTA

Downstream 100 bases:

>100_bases
CACCGATAAACAACGAGTCATAATTGATATTACGTACTCATTTATATAAAGCGCAAAGAAAAGCACTCAAGGTTCCATAA
TGAAACTCATGACTGTGTGC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MALATFGAGCFWGVEYFFREVEGVIDCTCGYMGGKDSYTRYAEVKTGTTGHAEVVQVEYDPNIVSYQRLLEVFWQNHNPT
TLNQQGGDIGSQYRSAVFFHDKQQKHQAEVAKLALIKSAKWGSRQIVTEVVPCQQFHQAEAYHQDYLAKNELPSCHISY

Sequences:

>Translated_159_residues
MALATFGAGCFWGVEYFFREVEGVIDCTCGYMGGKDSYTRYAEVKTGTTGHAEVVQVEYDPNIVSYQRLLEVFWQNHNPT
TLNQQGGDIGSQYRSAVFFHDKQQKHQAEVAKLALIKSAKWGSRQIVTEVVPCQQFHQAEAYHQDYLAKNELPSCHISY
>Mature_158_residues
ALATFGAGCFWGVEYFFREVEGVIDCTCGYMGGKDSYTRYAEVKTGTTGHAEVVQVEYDPNIVSYQRLLEVFWQNHNPTT
LNQQGGDIGSQYRSAVFFHDKQQKHQAEVAKLALIKSAKWGSRQIVTEVVPCQQFHQAEAYHQDYLAKNELPSCHISY

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=42.9487179487179, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=42.9487179487179, Blast_Score=120, Evalue=6e-28,
Organism=Homo sapiens, GI208609993, Length=103, Percent_Identity=45.6310679611651, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=43.7908496732026, Blast_Score=130, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=34.2465753424658, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=159, Percent_Identity=40.251572327044, Blast_Score=118, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=37.2413793103448, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=38.7755102040816, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI45553131, Length=138, Percent_Identity=35.5072463768116, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18038; Mature: 17907

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALATFGAGCFWGVEYFFREVEGVIDCTCGYMGGKDSYTRYAEVKTGTTGHAEVVQVEYD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEC
PNIVSYQRLLEVFWQNHNPTTLNQQGGDIGSQYRSAVFFHDKQQKHQAEVAKLALIKSAK
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCC
WGSRQIVTEVVPCQQFHQAEAYHQDYLAKNELPSCHISY
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure 
ALATFGAGCFWGVEYFFREVEGVIDCTCGYMGGKDSYTRYAEVKTGTTGHAEVVQVEYD
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEC
PNIVSYQRLLEVFWQNHNPTTLNQQGGDIGSQYRSAVFFHDKQQKHQAEVAKLALIKSAK
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCC
WGSRQIVTEVVPCQQFHQAEAYHQDYLAKNELPSCHISY
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]