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The map label for this gene is sdhB [H]

Identifier: 157961611

GI number: 157961611

Start: 2181712

End: 2182419

Strand: Direct

Name: sdhB [H]

Synonym: Spea_1787

Alternate gene names: 157961611

Gene position: 2181712-2182419 (Clockwise)

Preceding gene: 157961610

Following gene: 157961612

Centisome position: 42.16

GC content: 44.92

Gene sequence:

>708_bases
ATGAAATTGGAATTTGCAGTTTATCGCTACAATCCTGATGTAGATACGAAGCCGTATATGAAGGATTACAGCTTAGAAGT
GGATGAAGGTACTGACATGATGGTACTGGATGCACTTTTAAAGCTTAAAGAGCTAGATCCAACACTGGCGTTTAGACGTT
CATGCCGTGAAGGTGTATGTGGCAGTGATGGTATCAACATGAATGGTAAAAATGGACTCGCGTGTATCACGCCTGTTTCT
ACCTTCACTGGAAAGAAGATCGAAATCCGTCCGCTACCAGGCATGCCTGTTGTACGTGATTTGATTGTCGACCTGACTCA
GTTCTATACCCAGTATGAAAAGATAAAGCCTTTCTTGATTAACGATGAAAAAACGCCTGCGCGTGAGCATCTGCAGTCAC
CGGAAGATCGTGAGCACTTAGATGGACTCTATGAGTGTATTATGTGCGCATGTTGTTCTACGGCTTGTCCTTCGTTCTGG
TGGAACCCAGATAAGTTCATCGGTCCAAGTGGTTTGCTGCATGCTTACCGTTTCTTGATCGATAGCCGTGATACGGCGAC
TGAAGAGCGTTTATCTGGACTCGATGATGCTTACAGCGTGTTCCGCTGCCACGGCATCATGAACTGTGTTGACGTTTGTC
CTAAAGGGCTTAATCCGACAAAAGCAATTGGACATATCAAGTCTATGCTTCTGAAGAGAGCCGTTTAA

Upstream 100 bases:

>100_bases
CCCAGTAACCGAGCTAATGACTAAGCGTGATGTGAACATGCAGCCTAAGCTTCGTGACGCATTCCCGCCTATCAAACGTA
CTTACTAAGGAGAAGCCCCG

Downstream 100 bases:

>100_bases
ATGCAGTACCAAGAGCCGATATTGATATAGCTCTATACGAGTCACTTTCCCTGTGGAGAGTGACTCTTTTTTGTGTCATG
GAAGACGAATATAACGATAA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKLEFAVYRYNPDVDTKPYMKDYSLEVDEGTDMMVLDALLKLKELDPTLAFRRSCREGVCGSDGINMNGKNGLACITPVS
TFTGKKIEIRPLPGMPVVRDLIVDLTQFYTQYEKIKPFLINDEKTPAREHLQSPEDREHLDGLYECIMCACCSTACPSFW
WNPDKFIGPSGLLHAYRFLIDSRDTATEERLSGLDDAYSVFRCHGIMNCVDVCPKGLNPTKAIGHIKSMLLKRAV

Sequences:

>Translated_235_residues
MKLEFAVYRYNPDVDTKPYMKDYSLEVDEGTDMMVLDALLKLKELDPTLAFRRSCREGVCGSDGINMNGKNGLACITPVS
TFTGKKIEIRPLPGMPVVRDLIVDLTQFYTQYEKIKPFLINDEKTPAREHLQSPEDREHLDGLYECIMCACCSTACPSFW
WNPDKFIGPSGLLHAYRFLIDSRDTATEERLSGLDDAYSVFRCHGIMNCVDVCPKGLNPTKAIGHIKSMLLKRAV
>Mature_235_residues
MKLEFAVYRYNPDVDTKPYMKDYSLEVDEGTDMMVLDALLKLKELDPTLAFRRSCREGVCGSDGINMNGKNGLACITPVS
TFTGKKIEIRPLPGMPVVRDLIVDLTQFYTQYEKIKPFLINDEKTPAREHLQSPEDREHLDGLYECIMCACCSTACPSFW
WNPDKFIGPSGLLHAYRFLIDSRDTATEERLSGLDDAYSVFRCHGIMNCVDVCPKGLNPTKAIGHIKSMLLKRAV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=231, Percent_Identity=54.5454545454545, Blast_Score=268, Evalue=3e-72,
Organism=Escherichia coli, GI1786943, Length=236, Percent_Identity=77.1186440677966, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1790596, Length=229, Percent_Identity=38.8646288209607, Blast_Score=154, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17533915, Length=233, Percent_Identity=52.7896995708155, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6322987, Length=229, Percent_Identity=53.7117903930131, Blast_Score=255, Evalue=5e-69,
Organism=Drosophila melanogaster, GI17137106, Length=233, Percent_Identity=54.9356223175966, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24643156, Length=231, Percent_Identity=50.2164502164502, Blast_Score=250, Evalue=6e-67,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26558; Mature: 26558

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEFAVYRYNPDVDTKPYMKDYSLEVDEGTDMMVLDALLKLKELDPTLAFRRSCREGVC
CCCEEEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCC
GSDGINMNGKNGLACITPVSTFTGKKIEIRPLPGMPVVRDLIVDLTQFYTQYEKIKPFLI
CCCCCCCCCCCCEEEEECHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEE
NDEKTPAREHLQSPEDREHLDGLYECIMCACCSTACPSFWWNPDKFIGPSGLLHAYRFLI
CCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
DSRDTATEERLSGLDDAYSVFRCHGIMNCVDVCPKGLNPTKAIGHIKSMLLKRAV
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLEFAVYRYNPDVDTKPYMKDYSLEVDEGTDMMVLDALLKLKELDPTLAFRRSCREGVC
CCCEEEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCC
GSDGINMNGKNGLACITPVSTFTGKKIEIRPLPGMPVVRDLIVDLTQFYTQYEKIKPFLI
CCCCCCCCCCCCEEEEECHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEE
NDEKTPAREHLQSPEDREHLDGLYECIMCACCSTACPSFWWNPDKFIGPSGLLHAYRFLI
CCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
DSRDTATEERLSGLDDAYSVFRCHGIMNCVDVCPKGLNPTKAIGHIKSMLLKRAV
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]