Click here to switch to the map view.

The map label for this gene is sdhA [H]

Identifier: 157961610

GI number: 157961610

Start: 2179933

End: 2181699

Strand: Direct

Name: sdhA [H]

Synonym: Spea_1786

Alternate gene names: 157961610

Gene position: 2179933-2181699 (Clockwise)

Preceding gene: 157961609

Following gene: 157961611

Centisome position: 42.13

GC content: 48.22

Gene sequence:

>1767_bases
GTGGGTATTCCAGTTCGCGAATTTGACGCGGTTGTAATCGGAGCCGGTGGCGCGGGTATGCGTGCCGCTCTACAGATTTC
AAAAGAAGGTAAGAGCTGCGCGCTCTTATCTAAAGTTTTCCCAACTCGTTCTCATACCGTATCTGCACAGGGTGGTATTA
CCGTAGCACTGGGTAATGCACACGAAGATCACTGGGAACAGCACATGTACGATACCGTGAAAGGTTCCGATTTTATCGGT
GACCAAGAAGCGATTGAGTTTATGTGTAAGACAGGGCCTGAAGCGGTAATCGAGCTTGAGCACATGGGTCTACCATTCTC
ACGTTTCGAAAACGGCAAGATTTACCAGCGTCCTTTCGGTGGTCAGTCTAAAAACTTCGGTGGTGAGCAAGCGGCGCGTA
CAGCGGCTGCTGCCGACCGTACAGGTCACGCACTACTACATTGTCTATATCAGCAAAACGTTAAACATAAGACTGAAGTC
TTTTCTGAGTGGTATGCACTCGACTTAGTCAAAAATGAAGACGGCGTGATTGTGGGTTGTACGGCAATCGAAATTGAAAC
CGGCGAAATTGTTTATTTCAAAGCGAAAGCAACAATCTTGGCAACCGGTGGCGCAGGGCGCATCTACGCTTCAACCACTA
ACGCTCACATTAACACTGGCGACGGTGTTGGTATGGCGATGCGTGCCGGCGTTCAGATGCAAGACATGGAAATGTGGCAG
TTCCACCCAACGGGTATCGCTGGCGCAGGTGTTTTGGTGACTGAAGGTTGTCGTGGTGAAGGTGGTTACCTGCTAAACAA
AGATGGCGAACGCTTTATGGAGCGCTATGCACCGAATGCGAAAGACTTGGCATCTCGTGATGTAGTCGCACGTTCTATGA
TGACTGAAATTCGCGAAGGTCGTGGTCTCGATGGTCCATTAGGTCCGCACTGTCTTCTTAAGCTAGATCACTTAGGTAAA
GAAACCCTAGAAGCGCGCCTTCCAGGTGTTTGTGAATTGTCGCGTACATTCGCGCATATCGATCCCGCCGATGGTCCAAT
CCCAGTTCTTCCAACTTGTCACTACATGATGGGTGGTCTACCTGCAAAAGTGAGTGGTCAGGTTGTACGTCAAAATACAG
ATGGCAGTGAAGAAGAAATTACCGGTCTATTTGCAGTTGGTGAAATTGCGTGCGTTTCGGTACACGGAGCGAACCGATTG
GGTGGTAACTCATTGTTAGATCTTGTAGTATTTGGTCGAGCAGCGGGTCAACATTTAGGTAAAGCGTTAGATGAAACGCC
TACACCAAAAGAAGCTAGCCAGGCTGATATCGATGCTTCTCTTGCGCGTTTGAACCGCTGGGAAAGCAACAAAGATGGCG
AAGACCCTGCAGTGATCCGTAAAGACCTACAGCTTTGTATGCAGCTGAACTTCTCAGTATTTAGAAGTGGCGATGCGATG
GCTGAAGGCCTTAAAGAGCTTAAGGTGATCCGTGAACGTTTGGCTAACGCCAAGCTTTCAGATAACTCAACAGAATTTAA
TACTCAGCGTATTGAGTGTTTAGAGTTAGATAACTTGATGGCAACCGCAATTGCAACAGCTACGGCGGCCAATTTCCGTA
CCGAAAGTCGTGGTGCTCACTCTCGTGAAGATTACCTTGAGCGAGATGATGAAAACTGGCTATGTCATAGTATCTATGAC
CCAGTAACCGAGCTAATGACTAAGCGTGATGTGAACATGCAGCCTAAGCTTCGTGACGCATTCCCGCCTATCAAACGTAC
TTACTAA

Upstream 100 bases:

>100_bases
CGTTAAGTGCGTTGCACTACGTGGTGTACTTCAGTTTGTTTTTGTCATCGCCGCATTCAGCTATTTAGCTGCAGGCATTT
TGATTGTGTGGGGTGTTTAA

Downstream 100 bases:

>100_bases
GGAGAAGCCCCGATGAAATTGGAATTTGCAGTTTATCGCTACAATCCTGATGTAGATACGAAGCCGTATATGAAGGATTA
CAGCTTAGAAGTGGATGAAG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MGIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIG
DQEAIEFMCKTGPEAVIELEHMGLPFSRFENGKIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTEV
FSEWYALDLVKNEDGVIVGCTAIEIETGEIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGK
ETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPAKVSGQVVRQNTDGSEEEITGLFAVGEIACVSVHGANRL
GGNSLLDLVVFGRAAGQHLGKALDETPTPKEASQADIDASLARLNRWESNKDGEDPAVIRKDLQLCMQLNFSVFRSGDAM
AEGLKELKVIRERLANAKLSDNSTEFNTQRIECLELDNLMATAIATATAANFRTESRGAHSREDYLERDDENWLCHSIYD
PVTELMTKRDVNMQPKLRDAFPPIKRTY

Sequences:

>Translated_588_residues
MGIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIG
DQEAIEFMCKTGPEAVIELEHMGLPFSRFENGKIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTEV
FSEWYALDLVKNEDGVIVGCTAIEIETGEIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGK
ETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPAKVSGQVVRQNTDGSEEEITGLFAVGEIACVSVHGANRL
GGNSLLDLVVFGRAAGQHLGKALDETPTPKEASQADIDASLARLNRWESNKDGEDPAVIRKDLQLCMQLNFSVFRSGDAM
AEGLKELKVIRERLANAKLSDNSTEFNTQRIECLELDNLMATAIATATAANFRTESRGAHSREDYLERDDENWLCHSIYD
PVTELMTKRDVNMQPKLRDAFPPIKRTY
>Mature_587_residues
GIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIGD
QEAIEFMCKTGPEAVIELEHMGLPFSRFENGKIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTEVF
SEWYALDLVKNEDGVIVGCTAIEIETGEIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQF
HPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGKE
TLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPAKVSGQVVRQNTDGSEEEITGLFAVGEIACVSVHGANRLG
GNSLLDLVVFGRAAGQHLGKALDETPTPKEASQADIDASLARLNRWESNKDGEDPAVIRKDLQLCMQLNFSVFRSGDAMA
EGLKELKVIRERLANAKLSDNSTEFNTQRIECLELDNLMATAIATATAANFRTESRGAHSREDYLERDDENWLCHSIYDP
VTELMTKRDVNMQPKLRDAFPPIKRTY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=549, Percent_Identity=53.3697632058288, Blast_Score=522, Evalue=1e-148,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=79.0816326530612, Blast_Score=925, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=577, Percent_Identity=39.1681109185442, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1788928, Length=568, Percent_Identity=29.7535211267606, Blast_Score=207, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17550100, Length=594, Percent_Identity=48.1481481481481, Blast_Score=530, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17505833, Length=595, Percent_Identity=48.0672268907563, Blast_Score=528, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI71986328, Length=80, Percent_Identity=47.5, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322701, Length=593, Percent_Identity=51.0961214165261, Blast_Score=563, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6322416, Length=554, Percent_Identity=53.0685920577617, Blast_Score=560, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6320788, Length=490, Percent_Identity=26.9387755102041, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322511, Length=487, Percent_Identity=23.4086242299795, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137288, Length=548, Percent_Identity=53.2846715328467, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24655642, Length=548, Percent_Identity=53.2846715328467, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24655647, Length=548, Percent_Identity=53.2846715328467, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24663005, Length=618, Percent_Identity=46.1165048543689, Blast_Score=505, Evalue=1e-143,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64014; Mature: 63883

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDHWEQHMYDTVKGSDFIGDQEAIEFMCKTGPEAVIELEHMGLPFSRFENGKIYQRPFG
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHEEEEHHCCCCHHHCCCCEEEECCCC
GQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTEVFSEWYALDLVKNEDGVIVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHEEEEEECCCCEEEEE
TAIEIETGEIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCHHHHCCCCEECCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGLDGPLGPHCLLKLDHLGKETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGL
CCCCCCCCCHHEEEEHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC
PAKVSGQVVRQNTDGSEEEITGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGQHLG
CCCCCCEEEECCCCCCHHHHHEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KALDETPTPKEASQADIDASLARLNRWESNKDGEDPAVIRKDLQLCMQLNFSVFRSGDAM
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHCCCHHH
AEGLKELKVIRERLANAKLSDNSTEFNTQRIECLELDNLMATAIATATAANFRTESRGAH
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
SREDYLERDDENWLCHSIYDPVTELMTKRDVNMQPKLRDAFPPIKRTY
CHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHCCC
>Mature Secondary Structure 
GIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDHWEQHMYDTVKGSDFIGDQEAIEFMCKTGPEAVIELEHMGLPFSRFENGKIYQRPFG
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHEEEEHHCCCCHHHCCCCEEEECCCC
GQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTEVFSEWYALDLVKNEDGVIVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHEEEEEECCCCEEEEE
TAIEIETGEIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCHHHHCCCCEECCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGLDGPLGPHCLLKLDHLGKETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGL
CCCCCCCCCHHEEEEHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC
PAKVSGQVVRQNTDGSEEEITGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGQHLG
CCCCCCEEEECCCCCCHHHHHEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KALDETPTPKEASQADIDASLARLNRWESNKDGEDPAVIRKDLQLCMQLNFSVFRSGDAM
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHCCCHHH
AEGLKELKVIRERLANAKLSDNSTEFNTQRIECLELDNLMATAIATATAANFRTESRGAH
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
SREDYLERDDENWLCHSIYDPVTELMTKRDVNMQPKLRDAFPPIKRTY
CHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]