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The map label for this gene is purE [H]

Identifier: 157961039

GI number: 157961039

Start: 1475309

End: 1475812

Strand: Direct

Name: purE [H]

Synonym: Spea_1211

Alternate gene names: 157961039

Gene position: 1475309-1475812 (Clockwise)

Preceding gene: 157961038

Following gene: 157961040

Centisome position: 28.51

GC content: 47.42

Gene sequence:

>504_bases
ATGAGCAAACCATTTGTTGCAGTATTAATGGGATCTGATTCAGATCTGCCTACAATGCAAGCCACCCTCGATGTGCTTCG
AACTTTCGAAATCAACTTTGAAGCAAAAGTCACTTCAGCGCACCGTACGCCTGCTGCTACGCATGCCTACGTAACTGATG
CTGAAGCGCGTGGTTGTAAAGTCTTTATTTGTGCTGCAGGTCTTGCTGCACACTTAGCTGGTGCTGTAGCGGGTATTACT
ACTCGTCCAGTAATCGGTGTTCCAATTGATTGTGGTCCACTACAAGGCCACGATGCACTTTTATCAACCGTAATGATGCC
TGGCGGCGTTCCAGTAGCAACTGTTGCTATCGGTAGTGCTGGCGCTAAAAATGCGGGTTACCTTGCTGCGCAAATGTTAG
CTGTAGGTGATGATGCACTTGCTGTAGCCGTTAAAGAAGAGCGTGCTAAGTCTGCTGAAGCTGTTCAAGCTAAAGACGCA
GCTCTACAAGCTAAACTAGCTTAA

Upstream 100 bases:

>100_bases
TTGCGCCACAGGCTTGGGGGAAGCCTGTTTACTAAGTGCGCTAAATTTCAGTATAATGCGCGCAAATATAATAATGTACC
GCCCTACTCAAGGACTTAAA

Downstream 100 bases:

>100_bases
TTTAACAGGCACTTAGCCTGTCAATATCAAATGCTGCCTAGATACTTTCTAGGTGGCATTTTTTATGCCTGTTAAACTTG
TATAACTAGACAATAGTCTG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MSKPFVAVLMGSDSDLPTMQATLDVLRTFEINFEAKVTSAHRTPAATHAYVTDAEARGCKVFICAAGLAAHLAGAVAGIT
TRPVIGVPIDCGPLQGHDALLSTVMMPGGVPVATVAIGSAGAKNAGYLAAQMLAVGDDALAVAVKEERAKSAEAVQAKDA
ALQAKLA

Sequences:

>Translated_167_residues
MSKPFVAVLMGSDSDLPTMQATLDVLRTFEINFEAKVTSAHRTPAATHAYVTDAEARGCKVFICAAGLAAHLAGAVAGIT
TRPVIGVPIDCGPLQGHDALLSTVMMPGGVPVATVAIGSAGAKNAGYLAAQMLAVGDDALAVAVKEERAKSAEAVQAKDA
ALQAKLA
>Mature_166_residues
SKPFVAVLMGSDSDLPTMQATLDVLRTFEINFEAKVTSAHRTPAATHAYVTDAEARGCKVFICAAGLAAHLAGAVAGITT
RPVIGVPIDCGPLQGHDALLSTVMMPGGVPVATVAIGSAGAKNAGYLAAQMLAVGDDALAVAVKEERAKSAEAVQAKDAA
LQAKLA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=44.1441441441441, Blast_Score=94, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=163, Percent_Identity=46.6257668711656, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16869; Mature: 16737

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPFVAVLMGSDSDLPTMQATLDVLRTFEINFEAKVTSAHRTPAATHAYVTDAEARGCK
CCCCEEEEEECCCCCCCHHHHHHHHHHHEECCEEEEEECCCCCCCCCEEEEECCCCCCCE
VFICAAGLAAHLAGAVAGITTRPVIGVPIDCGPLQGHDALLSTVMMPGGVPVATVAIGSA
EEEEECCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCC
GAKNAGYLAAQMLAVGDDALAVAVKEERAKSAEAVQAKDAALQAKLA
CCCCCCHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
SKPFVAVLMGSDSDLPTMQATLDVLRTFEINFEAKVTSAHRTPAATHAYVTDAEARGCK
CCCEEEEEECCCCCCCHHHHHHHHHHHEECCEEEEEECCCCCCCCCEEEEECCCCCCCE
VFICAAGLAAHLAGAVAGITTRPVIGVPIDCGPLQGHDALLSTVMMPGGVPVATVAIGSA
EEEEECCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCC
GAKNAGYLAAQMLAVGDDALAVAVKEERAKSAEAVQAKDAALQAKLA
CCCCCCHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]