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The map label for this gene is hemH2 [H]

Identifier: 157960958

GI number: 157960958

Start: 1367696

End: 1368709

Strand: Direct

Name: hemH2 [H]

Synonym: Spea_1130

Alternate gene names: 157960958

Gene position: 1367696-1368709 (Clockwise)

Preceding gene: 157960957

Following gene: 157960963

Centisome position: 26.43

GC content: 49.7

Gene sequence:

>1014_bases
TTGGCTAAGTATTTAGGATTGACCAAGGACGTCGGCCACCAAGTACGTGGCAAGACGGGGGTGTTATTAGTTAATTTAGG
CACTCCAGATGAACCAACCCCCTCGGCGCTCAGGCGTTATTTGGCGGAGTTCCTAGCCGATCCCCGTGTAGTTGAGATCC
CGAAACTCGTTTGGATGCTTATCTTGCACGGTATTATCTTACGAGTTCGTCCAGCAAAATCAGCGGCGCTTTATAAACAG
GTGTGGACCGAGCAGGGCTCGCCGTTGATGGATATTACTCGCCGCCAAGCCCAAAAGCTGGCTGAGCACTTTGAAAAGAG
CGGCGAGGATGTCTCGGTGGACTTTTGTATGCGTTACGGCCAGCCGTCGGTGTCATCGACGCTGCAAAGAATGCATCAAG
AGGGCGTAGACAAGATGGTGATATTGCCTCTGTATCCGCAATACTCGGCGCCAACAACGGCGTCAGCTTTCGATGCAATC
GCCAAAGAGCTTGCTACTTGGCGGTATCTGCCTGCGCTACATTTTATCAATAGCTATCATGACCATCCTGACTTTATCGA
TGCACTAGCGGCATCTATCGCTAAAGACTTTGAGCTTAATGGTCAGCCGCAAAAGCTCGTGCTGTCATATCACGGTATGC
CGGAGCGAAACCTCCACTTGGGCGATCCCTATTATTGTTTCTGTATGAAGACGACTAAGCTGGTGGTCGAGAAGTTGGGA
CTAACTGGAGATCAGTATATAACCACCTTCCAATCTCGCTTCGGTAAAGCCAAATGGCTGACGCCCTATACCGATGCCAC
CATGGAAGCGCTACCTAGTCAGGGGATTAAAGACATTGCCGTGGTATGCCCAGCCTTTAGCGCCGATTGTTTAGAGACGT
TAGAGGAGATCGCTGGCGAAAATCGTGAGATCTTCGAACAGGCGGGTGGTGAAGAGTATCGATATATTGCCGCATTAAAT
GATAACGATGACCATATTCAGATGATGGCGAATATCGTTAAGCCGCATATTTAG

Upstream 100 bases:

>100_bases
TGGCAATATATTCAATTGCCAGCTTTTTTTACGGCCCGTGTTGAACTCAAAGCAGATTAAAACGTATCTGTAGATAATAT
TCAAAGGTTAAGGAGTTATC

Downstream 100 bases:

>100_bases
GCGTGTTTACTTCGTGTTCTCCGTGTAGCAAACGAAGAGAGCGCTTCGTGGTAAATAGCTTTTAAAGCAAAGAACCCAGC
TTGTGCTGGGTTCTTTGATT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 2; Protoheme ferro-lyase 2 [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAKYLGLTKDVGHQVRGKTGVLLVNLGTPDEPTPSALRRYLAEFLADPRVVEIPKLVWMLILHGIILRVRPAKSAALYKQ
VWTEQGSPLMDITRRQAQKLAEHFEKSGEDVSVDFCMRYGQPSVSSTLQRMHQEGVDKMVILPLYPQYSAPTTASAFDAI
AKELATWRYLPALHFINSYHDHPDFIDALAASIAKDFELNGQPQKLVLSYHGMPERNLHLGDPYYCFCMKTTKLVVEKLG
LTGDQYITTFQSRFGKAKWLTPYTDATMEALPSQGIKDIAVVCPAFSADCLETLEEIAGENREIFEQAGGEEYRYIAALN
DNDDHIQMMANIVKPHI

Sequences:

>Translated_337_residues
MAKYLGLTKDVGHQVRGKTGVLLVNLGTPDEPTPSALRRYLAEFLADPRVVEIPKLVWMLILHGIILRVRPAKSAALYKQ
VWTEQGSPLMDITRRQAQKLAEHFEKSGEDVSVDFCMRYGQPSVSSTLQRMHQEGVDKMVILPLYPQYSAPTTASAFDAI
AKELATWRYLPALHFINSYHDHPDFIDALAASIAKDFELNGQPQKLVLSYHGMPERNLHLGDPYYCFCMKTTKLVVEKLG
LTGDQYITTFQSRFGKAKWLTPYTDATMEALPSQGIKDIAVVCPAFSADCLETLEEIAGENREIFEQAGGEEYRYIAALN
DNDDHIQMMANIVKPHI
>Mature_336_residues
AKYLGLTKDVGHQVRGKTGVLLVNLGTPDEPTPSALRRYLAEFLADPRVVEIPKLVWMLILHGIILRVRPAKSAALYKQV
WTEQGSPLMDITRRQAQKLAEHFEKSGEDVSVDFCMRYGQPSVSSTLQRMHQEGVDKMVILPLYPQYSAPTTASAFDAIA
KELATWRYLPALHFINSYHDHPDFIDALAASIAKDFELNGQPQKLVLSYHGMPERNLHLGDPYYCFCMKTTKLVVEKLGL
TGDQYITTFQSRFGKAKWLTPYTDATMEALPSQGIKDIAVVCPAFSADCLETLEEIAGENREIFEQAGGEEYRYIAALND
NDDHIQMMANIVKPHI

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=330, Percent_Identity=27.5757575757576, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI60499021, Length=330, Percent_Identity=27.5757575757576, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786681, Length=316, Percent_Identity=48.4177215189873, Blast_Score=301, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6324750, Length=339, Percent_Identity=25.3687315634218, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17864156, Length=333, Percent_Identity=27.3273273273273, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24651774, Length=264, Percent_Identity=25.7575757575758, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45552018, Length=168, Percent_Identity=29.7619047619048, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 37893; Mature: 37762

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKYLGLTKDVGHQVRGKTGVLLVNLGTPDEPTPSALRRYLAEFLADPRVVEIPKLVWML
CCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
ILHGIILRVRPAKSAALYKQVWTEQGSPLMDITRRQAQKLAEHFEKSGEDVSVDFCMRYG
HHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCC
QPSVSSTLQRMHQEGVDKMVILPLYPQYSAPTTASAFDAIAKELATWRYLPALHFINSYH
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DHPDFIDALAASIAKDFELNGQPQKLVLSYHGMPERNLHLGDPYYCFCMKTTKLVVEKLG
CCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHC
LTGDQYITTFQSRFGKAKWLTPYTDATMEALPSQGIKDIAVVCPAFSADCLETLEEIAGE
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHCC
NREIFEQAGGEEYRYIAALNDNDDHIQMMANIVKPHI
CHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKYLGLTKDVGHQVRGKTGVLLVNLGTPDEPTPSALRRYLAEFLADPRVVEIPKLVWML
CCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
ILHGIILRVRPAKSAALYKQVWTEQGSPLMDITRRQAQKLAEHFEKSGEDVSVDFCMRYG
HHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCC
QPSVSSTLQRMHQEGVDKMVILPLYPQYSAPTTASAFDAIAKELATWRYLPALHFINSYH
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DHPDFIDALAASIAKDFELNGQPQKLVLSYHGMPERNLHLGDPYYCFCMKTTKLVVEKLG
CCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHC
LTGDQYITTFQSRFGKAKWLTPYTDATMEALPSQGIKDIAVVCPAFSADCLETLEEIAGE
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHCC
NREIFEQAGGEEYRYIAALNDNDDHIQMMANIVKPHI
CHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]