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The map label for this gene is folB [H]

Identifier: 157960793

GI number: 157960793

Start: 1176911

End: 1177264

Strand: Direct

Name: folB [H]

Synonym: Spea_0965

Alternate gene names: 157960793

Gene position: 1176911-1177264 (Clockwise)

Preceding gene: 157960790

Following gene: 157960794

Centisome position: 22.74

GC content: 44.63

Gene sequence:

>354_bases
ATGGATAAAGTACTGATTAGAGAACTTAGAATTGAAACCGTTATTGGGATCTATGAGTGGGAAAAACAGATCCACCAAAG
CTTACTTATCGATTTAGATATGGCTTGGAATAATCGCCCAGCAGCCGATAGCGATGATTATCAATTTGCACTGTGTTATG
AAACGGTATCGAATCGATTAACGGCATTGATCACTGAAAAGCCGATCGAGCTGATTGAAACCGTGGCTGAGATGGTGGCC
AATTGTGTGATGACTGAATTCAACGTGCCTTGGGTTAAGGTCAAGGTGATGAAGCCCGGTGCCATACCGTCAGCCGCTGC
CGTGGGTGTTGAGATTGAAAGAGGTTATGCGTAG

Upstream 100 bases:

>100_bases
AGCGTTAGACTAATATTTCAGCTTTGTGGCGGATTATATCTCTTTTGTCCGTTTTAGCTTATCTGACCTCAGTGTTATGG
ATTAAAGTTTTGGAGATATC

Downstream 100 bases:

>100_bases
ATGGCAACAATCTTTATAAGCTTGGGTAGCAATATCGACCCTGAGCGCCATCTTAAGGCTGCTTTAACGGACCTTCAGGA
CCATTTTGGGCCGCTTGAAT

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 117; Mature: 117

Protein sequence:

>117_residues
MDKVLIRELRIETVIGIYEWEKQIHQSLLIDLDMAWNNRPAADSDDYQFALCYETVSNRLTALITEKPIELIETVAEMVA
NCVMTEFNVPWVKVKVMKPGAIPSAAAVGVEIERGYA

Sequences:

>Translated_117_residues
MDKVLIRELRIETVIGIYEWEKQIHQSLLIDLDMAWNNRPAADSDDYQFALCYETVSNRLTALITEKPIELIETVAEMVA
NCVMTEFNVPWVKVKVMKPGAIPSAAAVGVEIERGYA
>Mature_117_residues
MDKVLIRELRIETVIGIYEWEKQIHQSLLIDLDMAWNNRPAADSDDYQFALCYETVSNRLTALITEKPIELIETVAEMVA
NCVMTEFNVPWVKVKVMKPGAIPSAAAVGVEIERGYA

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=115, Percent_Identity=46.0869565217391, Blast_Score=111, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13243; Mature: 13243

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKVLIRELRIETVIGIYEWEKQIHQSLLIDLDMAWNNRPAADSDDYQFALCYETVSNRL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEEHHHHHHHHH
TALITEKPIELIETVAEMVANCVMTEFNVPWVKVKVMKPGAIPSAAAVGVEIERGYA
EEHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MDKVLIRELRIETVIGIYEWEKQIHQSLLIDLDMAWNNRPAADSDDYQFALCYETVSNRL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEEHHHHHHHHH
TALITEKPIELIETVAEMVANCVMTEFNVPWVKVKVMKPGAIPSAAAVGVEIERGYA
EEHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]