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The map label for this gene is folK [H]

Identifier: 157960794

GI number: 157960794

Start: 1177265

End: 1177756

Strand: Direct

Name: folK [H]

Synonym: Spea_0966

Alternate gene names: 157960794

Gene position: 1177265-1177756 (Clockwise)

Preceding gene: 157960793

Following gene: 157960795

Centisome position: 22.75

GC content: 44.31

Gene sequence:

>492_bases
ATGGCAACAATCTTTATAAGCTTGGGTAGCAATATCGACCCTGAGCGCCATCTTAAGGCTGCTTTAACGGACCTTCAGGA
CCATTTTGGGCCGCTTGAATTGTCATCTGTGTTTGAAAGTGAAGCGGTGGGCTTTGAAGGGACTAACTTTCTTAATATGG
TGGTTGCGGCACAAACCCAGTTATCGATAGCTGATGTTGTGAGTCGATTTAAACAGATTGAGCAGCGTCATGGCCGAGTT
AAAGGTGCTAAGAAATTTGCCCCAAGAACCTTAGATTTAGATCTATTGCTGTATGACGATACCATTAGTGAGCAGCCTAT
TGAGTTGCCGAGAGCCGAGATCTTGTATAATGCCTTCGTTTTATGGCCATTAGCGGAAATTGCCCCCACTTTGAACCACC
CTGTTGTCAATCAATCGTATCAAGCCCTTTGGAATGATTACGATAAGAGTCAACAATCACTATGGCCTGTTGAGTTTAGC
TGGTCAGCGTAA

Upstream 100 bases:

>100_bases
TGAATTCAACGTGCCTTGGGTTAAGGTCAAGGTGATGAAGCCCGGTGCCATACCGTCAGCCGCTGCCGTGGGTGTTGAGA
TTGAAAGAGGTTATGCGTAG

Downstream 100 bases:

>100_bases
ACCTCTTTTTTATTTAGGATAGTTATGGATACCTTTCAGGTGATTATATTGGCTCTGATTCAGGGCCTCACCGAATTTTT
GCCGATCTCGAGTTCTGCAC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MATIFISLGSNIDPERHLKAALTDLQDHFGPLELSSVFESEAVGFEGTNFLNMVVAAQTQLSIADVVSRFKQIEQRHGRV
KGAKKFAPRTLDLDLLLYDDTISEQPIELPRAEILYNAFVLWPLAEIAPTLNHPVVNQSYQALWNDYDKSQQSLWPVEFS
WSA

Sequences:

>Translated_163_residues
MATIFISLGSNIDPERHLKAALTDLQDHFGPLELSSVFESEAVGFEGTNFLNMVVAAQTQLSIADVVSRFKQIEQRHGRV
KGAKKFAPRTLDLDLLLYDDTISEQPIELPRAEILYNAFVLWPLAEIAPTLNHPVVNQSYQALWNDYDKSQQSLWPVEFS
WSA
>Mature_162_residues
ATIFISLGSNIDPERHLKAALTDLQDHFGPLELSSVFESEAVGFEGTNFLNMVVAAQTQLSIADVVSRFKQIEQRHGRVK
GAKKFAPRTLDLDLLLYDDTISEQPIELPRAEILYNAFVLWPLAEIAPTLNHPVVNQSYQALWNDYDKSQQSLWPVEFSW
SA

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=141, Percent_Identity=34.7517730496454, Blast_Score=80, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324073, Length=167, Percent_Identity=33.5329341317365, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18403; Mature: 18272

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIFISLGSNIDPERHLKAALTDLQDHFGPLELSSVFESEAVGFEGTNFLNMVVAAQTQ
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LSIADVVSRFKQIEQRHGRVKGAKKFAPRTLDLDLLLYDDTISEQPIELPRAEILYNAFV
HHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
LWPLAEIAPTLNHPVVNQSYQALWNDYDKSQQSLWPVEFSWSA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCC
>Mature Secondary Structure 
ATIFISLGSNIDPERHLKAALTDLQDHFGPLELSSVFESEAVGFEGTNFLNMVVAAQTQ
EEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LSIADVVSRFKQIEQRHGRVKGAKKFAPRTLDLDLLLYDDTISEQPIELPRAEILYNAFV
HHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
LWPLAEIAPTLNHPVVNQSYQALWNDYDKSQQSLWPVEFSWSA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]