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The map label for this gene is pepQ [H]

Identifier: 157960748

GI number: 157960748

Start: 1126757

End: 1128544

Strand: Reverse

Name: pepQ [H]

Synonym: Spea_0920

Alternate gene names: 157960748

Gene position: 1128544-1126757 (Counterclockwise)

Preceding gene: 157960751

Following gene: 157960747

Centisome position: 21.81

GC content: 49.55

Gene sequence:

>1788_bases
ATGTCAAATACAATTGCAGCACGCCTTGATGCCATCCGCACAGAAATGGCCAAATCCAACCTCGATGCCTTTATCATTCC
CCGTGCCGATGAGTACTTGGGCGAATACGTACCCCAGCATAATGAACGTATGTTATGGGCCAGTGGATTTACCGGTTCTG
CCGGGGTGATTATCGTCCTTAAGACTCGCGCCGCTATCTTTATCGATGGCCGTTATACCGTGCAGGTTCGCCAGCAGCTA
GATGCAAACTTATTTGAGTTCCTAAGCTTACACGACACCCCCCAGGCCCAGTGGTTAATAGAACAACTTGGCGAAAATGC
GCAAGTGGGCTTTGACGCCCGTTTGCATACATTGGCTTGGTTTAACCAAACCCATAGCGAACTCGCTAAGGCGCAAATCC
AGCTAACGCAAGTTGAGCAAAACCCCATTGACCTAAATTGGAGCGACCGACCATCTCCTGCGTCTGAGCCAGTTATGCTA
TTTAGCGAACAAAGCGCGGGGCGAAGCAGCCTTGATAAGCGTACAAGCATTGGCTTAGAGATCAAGAAACAGGGCGCCGA
TGTCGCTATCATCTCGGCACTCGATTCTTTTTGCTGGCTGCTCAATATTCGCGGTAAAGATATTCCATGCTTACCTGTAG
TTTTAGGCACGGCGCTGTTACGTGCCAATGGCGATATGCTGCTATTTACCGATATCAACAAGCTGCCGGATAACATCCAT
GCTCACGTTGGTGAAGGCGTAAGCTTTAAGCATGAAGCTGAATTAGCGGCAGAGTTGGCAACACTCGCTGGCACTAAGGT
ATTGGCAAGCCCTGAGAGCTGCAACGCCTGGCTGCAACTGACAGCACAAGCGGCTGGGGCGCAATTAATTGCGGGCAACG
ATCCCGTCGCCCTGCCTAAAGCGCAAAAAAATGCCGCTGAACTTGCAGGCATGAAGGCCTGTCACATTCGCGATGGTGTA
TCAGTGAGCCGCTTCCTTGCTTGGTTAGACCGTGAAGTTGCTGCCAATCGACTTTATGATGAAGCGCTACTGGCCGATAA
ACTAGAAAGCTTCCGCTTAAGCGACCCTCAGTACCAAGAGCCAAGCTTCGATACCATTTCTGCTACAGGCGCCAATGCCG
CCATGTGCCATTACAATCATAACAACGGCACACCAGCACAGATGCAGATGAACAGCATCTACCTTGTTGACTCTGGTGCT
CAGTATTTAGATGGCACCACAGATGTCACTCGTACCATTGCTATTGGTGATGTCACCGACGAGCAAAGAAAGATGGTGAC
TCTAGTGCTCAAGGGGCATATCGCAATTGATCAAGCTAAGTTCCCTAAGGGCACTAGCGGCATGCAGCTTGACTCGTTTG
CTCGCCAATACCTATGGCAACACGGCTTTGATTTTGACCACGGAACCGGTCACGGTGTTGGCCACTACCTGAGTGTGCAT
GAAGGCCCACAAGGCATAGCTAAAGCTCGCTCCAACGTGGCGCTGCTCGAAGGCATGGTGTTATCTAATGAGCCGGGGTA
CTACCGCGCAGACGAGTTTGGTATTCGTTTAGAAAACTTAATCGTAGTTCGACCTTGTGAAGCTCTTGCCAATATCGAGC
GTGAAATGCTGGAGTTTGAAGCGTTGACTTTTATCCCGATGGACTTTCGCTTAATCGACAAGAGCTACTTAACGGATGCT
GAACTTACCTGGTTTAATCAATATCATCAGCAGGTTAAAGACAAGCTAACGCCCTTTATGCAAGGTGATGATTTAGATTG
GTTAAACAAGGTCACCGCAGCAATTTAG

Upstream 100 bases:

>100_bases
GCAATGGTCCTTTGTGGTACTCTCCGCGCTAAATTCGTACAAAAATAAACAGCCTCTAGCCCAGTAAAAGACTCGCTTTA
GCGCTGATAATGGAGTTTGA

Downstream 100 bases:

>100_bases
CCTAACTGTTAATCTGGTTAATCTGGTTAATCTGGTTAATCTGGTTAATCTGGTTAATCAACAAAAAAAATAAGAACCCA
GCACCAACTGGGTTCTTTGC

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MSNTIAARLDAIRTEMAKSNLDAFIIPRADEYLGEYVPQHNERMLWASGFTGSAGVIIVLKTRAAIFIDGRYTVQVRQQL
DANLFEFLSLHDTPQAQWLIEQLGENAQVGFDARLHTLAWFNQTHSELAKAQIQLTQVEQNPIDLNWSDRPSPASEPVML
FSEQSAGRSSLDKRTSIGLEIKKQGADVAIISALDSFCWLLNIRGKDIPCLPVVLGTALLRANGDMLLFTDINKLPDNIH
AHVGEGVSFKHEAELAAELATLAGTKVLASPESCNAWLQLTAQAAGAQLIAGNDPVALPKAQKNAAELAGMKACHIRDGV
SVSRFLAWLDREVAANRLYDEALLADKLESFRLSDPQYQEPSFDTISATGANAAMCHYNHNNGTPAQMQMNSIYLVDSGA
QYLDGTTDVTRTIAIGDVTDEQRKMVTLVLKGHIAIDQAKFPKGTSGMQLDSFARQYLWQHGFDFDHGTGHGVGHYLSVH
EGPQGIAKARSNVALLEGMVLSNEPGYYRADEFGIRLENLIVVRPCEALANIEREMLEFEALTFIPMDFRLIDKSYLTDA
ELTWFNQYHQQVKDKLTPFMQGDDLDWLNKVTAAI

Sequences:

>Translated_595_residues
MSNTIAARLDAIRTEMAKSNLDAFIIPRADEYLGEYVPQHNERMLWASGFTGSAGVIIVLKTRAAIFIDGRYTVQVRQQL
DANLFEFLSLHDTPQAQWLIEQLGENAQVGFDARLHTLAWFNQTHSELAKAQIQLTQVEQNPIDLNWSDRPSPASEPVML
FSEQSAGRSSLDKRTSIGLEIKKQGADVAIISALDSFCWLLNIRGKDIPCLPVVLGTALLRANGDMLLFTDINKLPDNIH
AHVGEGVSFKHEAELAAELATLAGTKVLASPESCNAWLQLTAQAAGAQLIAGNDPVALPKAQKNAAELAGMKACHIRDGV
SVSRFLAWLDREVAANRLYDEALLADKLESFRLSDPQYQEPSFDTISATGANAAMCHYNHNNGTPAQMQMNSIYLVDSGA
QYLDGTTDVTRTIAIGDVTDEQRKMVTLVLKGHIAIDQAKFPKGTSGMQLDSFARQYLWQHGFDFDHGTGHGVGHYLSVH
EGPQGIAKARSNVALLEGMVLSNEPGYYRADEFGIRLENLIVVRPCEALANIEREMLEFEALTFIPMDFRLIDKSYLTDA
ELTWFNQYHQQVKDKLTPFMQGDDLDWLNKVTAAI
>Mature_594_residues
SNTIAARLDAIRTEMAKSNLDAFIIPRADEYLGEYVPQHNERMLWASGFTGSAGVIIVLKTRAAIFIDGRYTVQVRQQLD
ANLFEFLSLHDTPQAQWLIEQLGENAQVGFDARLHTLAWFNQTHSELAKAQIQLTQVEQNPIDLNWSDRPSPASEPVMLF
SEQSAGRSSLDKRTSIGLEIKKQGADVAIISALDSFCWLLNIRGKDIPCLPVVLGTALLRANGDMLLFTDINKLPDNIHA
HVGEGVSFKHEAELAAELATLAGTKVLASPESCNAWLQLTAQAAGAQLIAGNDPVALPKAQKNAAELAGMKACHIRDGVS
VSRFLAWLDREVAANRLYDEALLADKLESFRLSDPQYQEPSFDTISATGANAAMCHYNHNNGTPAQMQMNSIYLVDSGAQ
YLDGTTDVTRTIAIGDVTDEQRKMVTLVLKGHIAIDQAKFPKGTSGMQLDSFARQYLWQHGFDFDHGTGHGVGHYLSVHE
GPQGIAKARSNVALLEGMVLSNEPGYYRADEFGIRLENLIVVRPCEALANIEREMLEFEALTFIPMDFRLIDKSYLTDAE
LTWFNQYHQQVKDKLTPFMQGDDLDWLNKVTAAI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=603, Percent_Identity=36.4842454394693, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI93141226, Length=599, Percent_Identity=34.2237061769616, Blast_Score=355, Evalue=6e-98,
Organism=Homo sapiens, GI264681565, Length=603, Percent_Identity=34.9917081260365, Blast_Score=341, Evalue=1e-93,
Organism=Escherichia coli, GI1788728, Length=224, Percent_Identity=29.9107142857143, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=591, Percent_Identity=35.1945854483926, Blast_Score=351, Evalue=5e-97,
Organism=Caenorhabditis elegans, GI25149105, Length=592, Percent_Identity=28.2094594594595, Blast_Score=238, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6322999, Length=650, Percent_Identity=31.6923076923077, Blast_Score=309, Evalue=7e-85,
Organism=Drosophila melanogaster, GI17137632, Length=604, Percent_Identity=37.7483443708609, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI161078230, Length=596, Percent_Identity=28.6912751677852, Blast_Score=267, Evalue=2e-71,
Organism=Drosophila melanogaster, GI21357287, Length=596, Percent_Identity=28.6912751677852, Blast_Score=267, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65803; Mature: 65672

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTIAARLDAIRTEMAKSNLDAFIIPRADEYLGEYVPQHNERMLWASGFTGSAGVIIVL
CCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEEECCCCCCCCEEEEE
KTRAAIFIDGRYTVQVRQQLDANLFEFLSLHDTPQAQWLIEQLGENAQVGFDARLHTLAW
ECCEEEEECCEEEEEEHHHHCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHH
FNQTHSELAKAQIQLTQVEQNPIDLNWSDRPSPASEPVMLFSEQSAGRSSLDKRTSIGLE
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCEE
IKKQGADVAIISALDSFCWLLNIRGKDIPCLPVVLGTALLRANGDMLLFTDINKLPDNIH
EECCCCCEEEHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHH
AHVGEGVSFKHEAELAAELATLAGTKVLASPESCNAWLQLTAQAAGAQLIAGNDPVALPK
HHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCHHEEEEEHHCCCEEEECCCCCCCCC
AQKNAAELAGMKACHIRDGVSVSRFLAWLDREVAANRLYDEALLADKLESFRLSDPQYQE
CCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PSFDTISATGANAAMCHYNHNNGTPAQMQMNSIYLVDSGAQYLDGTTDVTRTIAIGDVTD
CCCCEEECCCCCEEEEEEECCCCCCCEEEEEEEEEEECCCHHCCCCCCCEEEEEECCCCC
EQRKMVTLVLKGHIAIDQAKFPKGTSGMQLDSFARQYLWQHGFDFDHGTGHGVGHYLSVH
HHHHEEEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
EGPQGIAKARSNVALLEGMVLSNEPGYYRADEFGIRLENLIVVRPCEALANIEREMLEFE
CCCHHHHHHHCCCEEHCCEEECCCCCCEECHHHCEEEEEEEEEECHHHHHHHHHHHHHHH
ALTFIPMDFRLIDKSYLTDAELTWFNQYHQQVKDKLTPFMQGDDLDWLNKVTAAI
HEEEECCCCEECCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SNTIAARLDAIRTEMAKSNLDAFIIPRADEYLGEYVPQHNERMLWASGFTGSAGVIIVL
CCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEEECCCCCCCCEEEEE
KTRAAIFIDGRYTVQVRQQLDANLFEFLSLHDTPQAQWLIEQLGENAQVGFDARLHTLAW
ECCEEEEECCEEEEEEHHHHCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHH
FNQTHSELAKAQIQLTQVEQNPIDLNWSDRPSPASEPVMLFSEQSAGRSSLDKRTSIGLE
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCEE
IKKQGADVAIISALDSFCWLLNIRGKDIPCLPVVLGTALLRANGDMLLFTDINKLPDNIH
EECCCCCEEEHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHH
AHVGEGVSFKHEAELAAELATLAGTKVLASPESCNAWLQLTAQAAGAQLIAGNDPVALPK
HHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCHHEEEEEHHCCCEEEECCCCCCCCC
AQKNAAELAGMKACHIRDGVSVSRFLAWLDREVAANRLYDEALLADKLESFRLSDPQYQE
CCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PSFDTISATGANAAMCHYNHNNGTPAQMQMNSIYLVDSGAQYLDGTTDVTRTIAIGDVTD
CCCCEEECCCCCEEEEEEECCCCCCCEEEEEEEEEEECCCHHCCCCCCCEEEEEECCCCC
EQRKMVTLVLKGHIAIDQAKFPKGTSGMQLDSFARQYLWQHGFDFDHGTGHGVGHYLSVH
HHHHEEEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
EGPQGIAKARSNVALLEGMVLSNEPGYYRADEFGIRLENLIVVRPCEALANIEREMLEFE
CCCHHHHHHHCCCEEHCCEEECCCCCCEECHHHCEEEEEEEEEECHHHHHHHHHHHHHHH
ALTFIPMDFRLIDKSYLTDAELTWFNQYHQQVKDKLTPFMQGDDLDWLNKVTAAI
HEEEECCCCEECCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]