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The map label for this gene is fkpA [H]

Identifier: 157960751

GI number: 157960751

Start: 1131675

End: 1132145

Strand: Reverse

Name: fkpA [H]

Synonym: Spea_0923

Alternate gene names: 157960751

Gene position: 1132145-1131675 (Counterclockwise)

Preceding gene: 157960755

Following gene: 157960748

Centisome position: 21.88

GC content: 44.8

Gene sequence:

>471_bases
ATGAAGATGGTTTTAGCTGTTGTGGTAATTGCTTGTGTTGTGTTTTACTTTTTTTCGTCAATGAACAACCAGAAAGCGGC
CAAAGAAAATATCGCCTTAGGCAATGCATTCCTTGCCGAGAATAAGCTAAAAGATGGCGTAACAACCACAGCTTCAGGAC
TGCAGTATCAAGTTCTTGAACCCGGTACTGGCACTGTACATCCAAAGGCGAGCGACACAGTTACCGTGCACTATCACGGC
ACCTTAATCGATGGCACTGTTTTCGATAGCTCTGTTGAACGTGGTGAGCCAATTGCATTCCCACTTAATCGTGTAATTAA
AGGGTGGACCGAAGGTGTACAGTTGATGGTTGTGGGTGAGAAAGCGCGCTTCTTCATTCCAAGTGAGCTGGCTTATGGTA
ATCGCAGTGCAGGCAAAATTTCCGGCGGATCAACCCTGATTTTTGATGTTGAGCTAATCAGTATCGATTAA

Upstream 100 bases:

>100_bases
GTCTATAAAACGGCAATCTTCAAAGAGAAGTACCGAGATTTACCTCTAGGGGGGGATTCGCTATCATAAGCGGTCAAATT
AAAACAAGGTGACTCGAAAA

Downstream 100 bases:

>100_bases
TAACTTACTTTACCTGATTAAAAAGAAAGCCCGAATGGTTAAGCATTCGGGCTTTTTGTTTGGCATTAATTTAAAGTATT
ACGCTTCGTAACCAAATGGC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MKMVLAVVVIACVVFYFFSSMNNQKAAKENIALGNAFLAENKLKDGVTTTASGLQYQVLEPGTGTVHPKASDTVTVHYHG
TLIDGTVFDSSVERGEPIAFPLNRVIKGWTEGVQLMVVGEKARFFIPSELAYGNRSAGKISGGSTLIFDVELISID

Sequences:

>Translated_156_residues
MKMVLAVVVIACVVFYFFSSMNNQKAAKENIALGNAFLAENKLKDGVTTTASGLQYQVLEPGTGTVHPKASDTVTVHYHG
TLIDGTVFDSSVERGEPIAFPLNRVIKGWTEGVQLMVVGEKARFFIPSELAYGNRSAGKISGGSTLIFDVELISID
>Mature_156_residues
MKMVLAVVVIACVVFYFFSSMNNQKAAKENIALGNAFLAENKLKDGVTTTASGLQYQVLEPGTGTVHPKASDTVTVHYHG
TLIDGTVFDSSVERGEPIAFPLNRVIKGWTEGVQLMVVGEKARFFIPSELAYGNRSAGKISGGSTLIFDVELISID

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=94, Percent_Identity=47.8723404255319, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI17149844, Length=94, Percent_Identity=47.8723404255319, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI17149842, Length=94, Percent_Identity=47.8723404255319, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=43.9252336448598, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=43.9252336448598, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=39.2523364485981, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI4503727, Length=139, Percent_Identity=35.2517985611511, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4503729, Length=97, Percent_Identity=44.3298969072165, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI8923659, Length=92, Percent_Identity=43.4782608695652, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI224809329, Length=140, Percent_Identity=37.8571428571429, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI224809327, Length=140, Percent_Identity=37.8571428571429, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI4758384, Length=140, Percent_Identity=37.8571428571429, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI224809331, Length=139, Percent_Identity=38.1294964028777, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI7706131, Length=107, Percent_Identity=39.2523364485981, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI33469985, Length=88, Percent_Identity=38.6363636363636, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI192448443, Length=112, Percent_Identity=37.5, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI87082390, Length=125, Percent_Identity=56, Blast_Score=131, Evalue=2e-32,
Organism=Escherichia coli, GI1789745, Length=132, Percent_Identity=48.4848484848485, Blast_Score=116, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17561782, Length=98, Percent_Identity=52.0408163265306, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540882, Length=91, Percent_Identity=50.5494505494505, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71993519, Length=107, Percent_Identity=42.0560747663551, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=101, Percent_Identity=49.5049504950495, Blast_Score=94, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=56.8181818181818, Blast_Score=91, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323482, Length=91, Percent_Identity=41.7582417582418, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323566, Length=84, Percent_Identity=45.2380952380952, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=45.7943925233645, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281363946, Length=157, Percent_Identity=36.3057324840764, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17352457, Length=157, Percent_Identity=36.3057324840764, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=41.3461538461538, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356629, Length=96, Percent_Identity=44.7916666666667, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16772; Mature: 16772

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMVLAVVVIACVVFYFFSSMNNQKAAKENIALGNAFLAENKLKDGVTTTASGLQYQVLE
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHCCCCCCCCEECCCCCEEEEEC
PGTGTVHPKASDTVTVHYHGTLIDGTVFDSSVERGEPIAFPLNRVIKGWTEGVQLMVVGE
CCCCEECCCCCCEEEEEEECEEEECEEECCCCCCCCCCEECHHHHHHHHCCCEEEEEECC
KARFFIPSELAYGNRSAGKISGGSTLIFDVELISID
CCEEEECCHHCCCCCCCCEECCCCEEEEEEEEEEEC
>Mature Secondary Structure
MKMVLAVVVIACVVFYFFSSMNNQKAAKENIALGNAFLAENKLKDGVTTTASGLQYQVLE
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHCCCCCCCCEECCCCCEEEEEC
PGTGTVHPKASDTVTVHYHGTLIDGTVFDSSVERGEPIAFPLNRVIKGWTEGVQLMVVGE
CCCCEECCCCCCEEEEEEECEEEECEEECCCCCCCCCCEECHHHHHHHHCCCEEEEEECC
KARFFIPSELAYGNRSAGKISGGSTLIFDVELISID
CCEEEECCHHCCCCCCCCEECCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]