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The map label for this gene is panB [H]

Identifier: 157960522

GI number: 157960522

Start: 854565

End: 855359

Strand: Reverse

Name: panB [H]

Synonym: Spea_0694

Alternate gene names: 157960522

Gene position: 855359-854565 (Counterclockwise)

Preceding gene: 157960523

Following gene: 157960521

Centisome position: 16.53

GC content: 50.69

Gene sequence:

>795_bases
ATGTCCAAAATTACAAGTTCTACACTACGCACCTTCAAGCAAGAAGGTAAGAAGTTCACCGCATTAACGGCCTATGACGC
CAGCTTTGCCGGCGCGTTCGATAGCGAAGGTATTGACGTGTTACTCGTCGGTGATTCTATGGGGATGGTACTGCAAGGAC
ATAGCGATACCCTGCCAGTGACTGTCGAGGAAATTGCCTACCACACACGTTGCGTTCGTCGTGGTATCGAGCGTGCTCTG
CTAATCGCCGACATGCCATTTATGAGTTATGCGACACCAGAGCAAACCATGATCAATGCCACCACGCTGATGCAAGCAGG
TGCAAACATGGTTAAAGTTGAAGGTGGTAAATGGCTACTCGAGAGCGTAGCCATGCTAACTGAGCGCGGCATTCCAGTCT
GCGCACACTTAGGCTTAACGCCTCAGTCTGTACACGTTTTTGGCGGCTTTAAAGTGCAAGGGCGAGATGCCGACAATGCT
CAGCGCATTCTTGACGAAGCCAAGGCTCTAGAGGCGGCGGGAGCTCAACTGTTAGTGGTTGAATGCATACCGGCACCATT
AGCCAAAGCGATTACCGACGCCCTGACTATTCCAGTTATCGGTATTGGCGCGGGTAAAGACACCGACGGCCAAATCTTAG
TCATGCACGATGTACTTGGGATCTCTAGCGGTTATATTCCGCGTTTCTCTAAAAACTATCTCAAGCAGACGGGTGAAATT
CGCGCCGCCGTTCGTGCCTATATTGATGAAGTCGCCCAAGGGATCTTCCCTGGTAGCGAGCACACCTTTAATTAA

Upstream 100 bases:

>100_bases
TATTTCGCATCTGTTATATAAGGGTTTAACACCGAGATCATTGAAGTGAGCCCATGTTGGCCTATAACTACTTCACAAAT
TGGGTTAGAAAGTTACCATT

Downstream 100 bases:

>100_bases
TTTCTAATCATTCGCTCTCAGCCTATGGGTTGAGAGCCATTGTTTAAATTGAGTACCAGAGCAGTAAAACCATGATCACC
ACTCAATCTATTTCTGATAT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSKITSSTLRTFKQEGKKFTALTAYDASFAGAFDSEGIDVLLVGDSMGMVLQGHSDTLPVTVEEIAYHTRCVRRGIERAL
LIADMPFMSYATPEQTMINATTLMQAGANMVKVEGGKWLLESVAMLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDADNA
QRILDEAKALEAAGAQLLVVECIPAPLAKAITDALTIPVIGIGAGKDTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEI
RAAVRAYIDEVAQGIFPGSEHTFN

Sequences:

>Translated_264_residues
MSKITSSTLRTFKQEGKKFTALTAYDASFAGAFDSEGIDVLLVGDSMGMVLQGHSDTLPVTVEEIAYHTRCVRRGIERAL
LIADMPFMSYATPEQTMINATTLMQAGANMVKVEGGKWLLESVAMLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDADNA
QRILDEAKALEAAGAQLLVVECIPAPLAKAITDALTIPVIGIGAGKDTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEI
RAAVRAYIDEVAQGIFPGSEHTFN
>Mature_263_residues
SKITSSTLRTFKQEGKKFTALTAYDASFAGAFDSEGIDVLLVGDSMGMVLQGHSDTLPVTVEEIAYHTRCVRRGIERALL
IADMPFMSYATPEQTMINATTLMQAGANMVKVEGGKWLLESVAMLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDADNAQ
RILDEAKALEAAGAQLLVVECIPAPLAKAITDALTIPVIGIGAGKDTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEIR
AAVRAYIDEVAQGIFPGSEHTFN

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=264, Percent_Identity=64.0151515151515, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319653, Length=258, Percent_Identity=36.4341085271318, Blast_Score=165, Evalue=7e-42,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28289; Mature: 28158

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKITSSTLRTFKQEGKKFTALTAYDASFAGAFDSEGIDVLLVGDSMGMVLQGHSDTLPV
CCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCE
TVEEIAYHTRCVRRGIERALLIADMPFMSYATPEQTMINATTLMQAGANMVKVEGGKWLL
EHHHHHHHHHHHHHHHHHEEHEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHH
ESVAMLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDADNAQRILDEAKALEAAGAQLLVV
HHHHHHHHCCCCEEEECCCCCCEEEEEECEEEECCCCCHHHHHHHHHHHHHHCCCEEEEE
ECIPAPLAKAITDALTIPVIGIGAGKDTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEI
EECCHHHHHHHHHHHHHCEEEECCCCCCCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHH
RAAVRAYIDEVAQGIFPGSEHTFN
HHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SKITSSTLRTFKQEGKKFTALTAYDASFAGAFDSEGIDVLLVGDSMGMVLQGHSDTLPV
CCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCE
TVEEIAYHTRCVRRGIERALLIADMPFMSYATPEQTMINATTLMQAGANMVKVEGGKWLL
EHHHHHHHHHHHHHHHHHEEHEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHH
ESVAMLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDADNAQRILDEAKALEAAGAQLLVV
HHHHHHHHCCCCEEEECCCCCCEEEEEECEEEECCCCCHHHHHHHHHHHHHHCCCEEEEE
ECIPAPLAKAITDALTIPVIGIGAGKDTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEI
EECCHHHHHHHHHHHHHCEEEECCCCCCCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHH
RAAVRAYIDEVAQGIFPGSEHTFN
HHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA