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The map label for this gene is panC

Identifier: 157960521

GI number: 157960521

Start: 853642

End: 854493

Strand: Reverse

Name: panC

Synonym: Spea_0693

Alternate gene names: 157960521

Gene position: 854493-853642 (Counterclockwise)

Preceding gene: 157960522

Following gene: 157960520

Centisome position: 16.51

GC content: 47.07

Gene sequence:

>852_bases
ATGATCACCACTCAATCTATTTCTGATATCCGCAAACAAGTAACTGCATGGCGACTAAAGGGCGAAACAGTTGCCTTTGT
CCCAACTATGGGTAACTTGCACTTAGGGCATATCACCTTAGTTAAAGAAGCAAAGACACGTGCCGATCACGTGGTGGCTT
CTATTTTTGTTAATCCAATGCAGTTTGGCCAAAACGAAGATCTCGACGCCTACCCAAGAACCTTAGCCGATGATCAAGCA
GCGCTCATCGAAGCTGGCGCCGAGTTACTGTTCACCCCAACGCCGGATATCATCTACCCAAAAGGTATGGATGCGCAGAC
CTTTGTTGAGGTGCCAAGCATTTCCGATGAACTCTGTGGCGCCAGTCGCCCGGGTCACTTCAGAGGCGTGGCGACCATAG
TTTGCAAGCTGTTCAACATAGTACAGCCTGACATTGCAGTATTTGGCCAAAAAGACTTTCAGCAGTTATTAGTGATCCGC
ACCATGGTAGAAGACTTATCTATGCCAATTGAGATTGTCGGCATCGAGACGATACGTGAAACCTCAGGCCTTGCCATGAG
TTCTCGTAACGGCTACCTAACGACTGAACAAAAAGATCAGGCTTCGCAGATAAAACGCACCTTAAATAATATGGCCCTGT
CGCTTAAAGCGGGCTTACTGATTAAGGATGTGGTCGCCAAGGCACAAGCAGAACTCGTGCATGTCGGCTTTAGAAACGAT
TATCTCGATGTGAGAAACGCCAATACTTTTGCCATCGCAACGGCTGCAGATAAAGACTTGGTCATTTTAGTCGCCGCTTA
CATGGGCTCGACACGACTAATTGATAATTTAGTGGTCAAGTTAGCCTACTAA

Upstream 100 bases:

>100_bases
TCCCTGGTAGCGAGCACACCTTTAATTAATTTCTAATCATTCGCTCTCAGCCTATGGGTTGAGAGCCATTGTTTAAATTG
AGTACCAGAGCAGTAAAACC

Downstream 100 bases:

>100_bases
TATTAAGTTTGTTACAACAAAGCAATTTTAAGACAATTTTGCCTGCAAGAATTGAACGGTTCAAAATACAGTTTTGAGCC
GTTTTTTATTGCCCTGCCAA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MITTQSISDIRKQVTAWRLKGETVAFVPTMGNLHLGHITLVKEAKTRADHVVASIFVNPMQFGQNEDLDAYPRTLADDQA
ALIEAGAELLFTPTPDIIYPKGMDAQTFVEVPSISDELCGASRPGHFRGVATIVCKLFNIVQPDIAVFGQKDFQQLLVIR
TMVEDLSMPIEIVGIETIRETSGLAMSSRNGYLTTEQKDQASQIKRTLNNMALSLKAGLLIKDVVAKAQAELVHVGFRND
YLDVRNANTFAIATAADKDLVILVAAYMGSTRLIDNLVVKLAY

Sequences:

>Translated_283_residues
MITTQSISDIRKQVTAWRLKGETVAFVPTMGNLHLGHITLVKEAKTRADHVVASIFVNPMQFGQNEDLDAYPRTLADDQA
ALIEAGAELLFTPTPDIIYPKGMDAQTFVEVPSISDELCGASRPGHFRGVATIVCKLFNIVQPDIAVFGQKDFQQLLVIR
TMVEDLSMPIEIVGIETIRETSGLAMSSRNGYLTTEQKDQASQIKRTLNNMALSLKAGLLIKDVVAKAQAELVHVGFRND
YLDVRNANTFAIATAADKDLVILVAAYMGSTRLIDNLVVKLAY
>Mature_283_residues
MITTQSISDIRKQVTAWRLKGETVAFVPTMGNLHLGHITLVKEAKTRADHVVASIFVNPMQFGQNEDLDAYPRTLADDQA
ALIEAGAELLFTPTPDIIYPKGMDAQTFVEVPSISDELCGASRPGHFRGVATIVCKLFNIVQPDIAVFGQKDFQQLLVIR
TMVEDLSMPIEIVGIETIRETSGLAMSSRNGYLTTEQKDQASQIKRTLNNMALSLKAGLLIKDVVAKAQAELVHVGFRND
YLDVRNANTFAIATAADKDLVILVAAYMGSTRLIDNLVVKLAY

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=283, Percent_Identity=51.9434628975265, Blast_Score=289, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6322046, Length=302, Percent_Identity=37.4172185430464, Blast_Score=179, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_SHEPA (A8H0D3)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001500555.1
- ProteinModelPortal:   A8H0D3
- SMR:   A8H0D3
- STRING:   A8H0D3
- GeneID:   5661092
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_0693
- NMPDR:   fig|398579.3.peg.610
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   SPEA398579:SPEA_0693-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31022; Mature: 31022

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTQSISDIRKQVTAWRLKGETVAFVPTMGNLHLGHITLVKEAKTRADHVVASIFVNPM
CCCCCHHHHHHHHHHHHEECCCEEEEEECCCCEEECEEEEEHHHHHHHHHHHHHHHHCHH
QFGQNEDLDAYPRTLADDQAALIEAGAELLFTPTPDIIYPKGMDAQTFVEVPSISDELCG
HCCCCCCCCCCCCHHCCCHHHHHHCCCCEEEECCCCEECCCCCCHHHEEECCCCCHHHCC
ASRPGHFRGVATIVCKLFNIVQPDIAVFGQKDFQQLLVIRTMVEDLSMPIEIVGIETIRE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHH
TSGLAMSSRNGYLTTEQKDQASQIKRTLNNMALSLKAGLLIKDVVAKAQAELVHVGFRND
CCCCEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEECCCC
YLDVRNANTFAIATAADKDLVILVAAYMGSTRLIDNLVVKLAY
EEEECCCCEEEEEEECCCCEEEEEEHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure
MITTQSISDIRKQVTAWRLKGETVAFVPTMGNLHLGHITLVKEAKTRADHVVASIFVNPM
CCCCCHHHHHHHHHHHHEECCCEEEEEECCCCEEECEEEEEHHHHHHHHHHHHHHHHCHH
QFGQNEDLDAYPRTLADDQAALIEAGAELLFTPTPDIIYPKGMDAQTFVEVPSISDELCG
HCCCCCCCCCCCCHHCCCHHHHHHCCCCEEEECCCCEECCCCCCHHHEEECCCCCHHHCC
ASRPGHFRGVATIVCKLFNIVQPDIAVFGQKDFQQLLVIRTMVEDLSMPIEIVGIETIRE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHH
TSGLAMSSRNGYLTTEQKDQASQIKRTLNNMALSLKAGLLIKDVVAKAQAELVHVGFRND
CCCCEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEECCCC
YLDVRNANTFAIATAADKDLVILVAAYMGSTRLIDNLVVKLAY
EEEECCCCEEEEEEECCCCEEEEEEHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA