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The map label for this gene is nrdF [H]

Identifier: 157825769

GI number: 157825769

Start: 628552

End: 629535

Strand: Direct

Name: nrdF [H]

Synonym: A1C_03485

Alternate gene names: 157825769

Gene position: 628552-629535 (Clockwise)

Preceding gene: 157825768

Following gene: 157825770

Centisome position: 51.06

GC content: 36.08

Gene sequence:

>984_bases
ATGTCACTACTTGATGCAAGTCCAATATATAAGCCATTTTCATATCCATGGGCATATACAGCTTGGCACACTCAACAAAA
AATTCATTGGTTACCGGAAGAAGTACCGCTTGCCGATGATGTGAAAGATTGGAAGTATAACTTAACTCCAGGGGAAAAAC
ATCTATTAACACAAATATTTCGTTTTTTTACTCAGGCGGATATTGAAGTGAATAACTGCTATATGAAGCATTATTCACGA
GTATTTAAACCGACTGAAATATTAATGATGTTATCGGCATTTTCTAATATGGAAACGGTACATATTGCAGCATATTCACA
TTTACTTGATACGGTAGGTATGCCGGAAGTAGAATATTCAGCATTTCTTAAATATAAGGAAATGAAAGACAAGTATGATT
ATATACAGCAATTTGGAGTGGATACCAAAGAAGATATAGCAACTACACTCGCAGTATTTGGAGCTTTTACTGAAGGATTA
CAGCTATTTGCTTCTTTTGCGATTATGCTTAATTTCCCTCGTTTTAATAAAATGAAAGGTATGGGTCAGATTATTTCTTG
GTCAGTGCGTGATGAAACTCTTCATACTAATTCAATTATTACTCTGTTTAAGACTTTTGTAAGAGAGAACCCTGAAGTTT
GGACAGAAACTTTACGTAAACGTATTTATGAAGCTTGTACAACTATTGTGCATTTTGAAGATGCCTTTATTGAACTTGCG
TTTGAAGTTGGCGGTATTGAAGGGTTAACGGCATATGAAGTAAGACAATATATTCGTTATATTGCTGACCGTCGTTTAAT
GCAACTAGGGCTCAAAGATGTATATTTGGTCAATCATAACCCGCTTCCTTGGCTTGATGAAATGCTAAATGGAGTCGAGC
ATACGAACTTTTTTGAAAATAGAGCGACTGAATATTCAAAAGCGGCGACTACCGGTTCATGGGAAGAAGTATTCACTCAG
ATGGACGCCAAAAGAGGAGGCTAA

Upstream 100 bases:

>100_bases
TTTTTAGGTTCCTGCTTTCGCAGGAATGACATTGAGTATTTTTTTGAGTCATACCACAAAGTATACTGGTAAATAATAAA
AACAAACAAGAAGAACAATT

Downstream 100 bases:

>100_bases
AGAATATACTAAGATAGAACTTGAAAATTGGCAGCCGTGTCTTTGTAAGCCTTCGGATGCTGAACATGTTGTATCGAAGT
ATACATATTAACAACAACAA

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSLLDASPIYKPFSYPWAYTAWHTQQKIHWLPEEVPLADDVKDWKYNLTPGEKHLLTQIFRFFTQADIEVNNCYMKHYSR
VFKPTEILMMLSAFSNMETVHIAAYSHLLDTVGMPEVEYSAFLKYKEMKDKYDYIQQFGVDTKEDIATTLAVFGAFTEGL
QLFASFAIMLNFPRFNKMKGMGQIISWSVRDETLHTNSIITLFKTFVRENPEVWTETLRKRIYEACTTIVHFEDAFIELA
FEVGGIEGLTAYEVRQYIRYIADRRLMQLGLKDVYLVNHNPLPWLDEMLNGVEHTNFFENRATEYSKAATTGSWEEVFTQ
MDAKRGG

Sequences:

>Translated_327_residues
MSLLDASPIYKPFSYPWAYTAWHTQQKIHWLPEEVPLADDVKDWKYNLTPGEKHLLTQIFRFFTQADIEVNNCYMKHYSR
VFKPTEILMMLSAFSNMETVHIAAYSHLLDTVGMPEVEYSAFLKYKEMKDKYDYIQQFGVDTKEDIATTLAVFGAFTEGL
QLFASFAIMLNFPRFNKMKGMGQIISWSVRDETLHTNSIITLFKTFVRENPEVWTETLRKRIYEACTTIVHFEDAFIELA
FEVGGIEGLTAYEVRQYIRYIADRRLMQLGLKDVYLVNHNPLPWLDEMLNGVEHTNFFENRATEYSKAATTGSWEEVFTQ
MDAKRGG
>Mature_326_residues
SLLDASPIYKPFSYPWAYTAWHTQQKIHWLPEEVPLADDVKDWKYNLTPGEKHLLTQIFRFFTQADIEVNNCYMKHYSRV
FKPTEILMMLSAFSNMETVHIAAYSHLLDTVGMPEVEYSAFLKYKEMKDKYDYIQQFGVDTKEDIATTLAVFGAFTEGLQ
LFASFAIMLNFPRFNKMKGMGQIISWSVRDETLHTNSIITLFKTFVRENPEVWTETLRKRIYEACTTIVHFEDAFIELAF
EVGGIEGLTAYEVRQYIRYIADRRLMQLGLKDVYLVNHNPLPWLDEMLNGVEHTNFFENRATEYSKAATTGSWEEVFTQM
DAKRGG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI42544136, Length=321, Percent_Identity=29.595015576324, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI289177074, Length=321, Percent_Identity=29.595015576324, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4557845, Length=320, Percent_Identity=28.125, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI260064013, Length=320, Percent_Identity=28.125, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI289177076, Length=300, Percent_Identity=29.6666666666667, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17551968, Length=283, Percent_Identity=27.5618374558304, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6322434, Length=303, Percent_Identity=25.7425742574257, Blast_Score=89, Evalue=6e-19,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=28.75, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 38195; Mature: 38064

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLDASPIYKPFSYPWAYTAWHTQQKIHWLPEEVPLADDVKDWKYNLTPGEKHLLTQIF
CCCCCCCCCCCCCCCCCEEEHHCCCHHHHCCCCCCCCCCCCCCCEECCCCCHHHHHHHHH
RFFTQADIEVNNCYMKHYSRVFKPTEILMMLSAFSNMETVHIAAYSHLLDTVGMPEVEYS
HHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCHHHH
AFLKYKEMKDKYDYIQQFGVDTKEDIATTLAVFGAFTEGLQLFASFAIMLNFPRFNKMKG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
MGQIISWSVRDETLHTNSIITLFKTFVRENPEVWTETLRKRIYEACTTIVHFEDAFIELA
CCHHHEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEVGGIEGLTAYEVRQYIRYIADRRLMQLGLKDVYLVNHNPLPWLDEMLNGVEHTNFFEN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
RATEYSKAATTGSWEEVFTQMDAKRGG
HHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLLDASPIYKPFSYPWAYTAWHTQQKIHWLPEEVPLADDVKDWKYNLTPGEKHLLTQIF
CCCCCCCCCCCCCCCCEEEHHCCCHHHHCCCCCCCCCCCCCCCEECCCCCHHHHHHHHH
RFFTQADIEVNNCYMKHYSRVFKPTEILMMLSAFSNMETVHIAAYSHLLDTVGMPEVEYS
HHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCHHHH
AFLKYKEMKDKYDYIQQFGVDTKEDIATTLAVFGAFTEGLQLFASFAIMLNFPRFNKMKG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
MGQIISWSVRDETLHTNSIITLFKTFVRENPEVWTETLRKRIYEACTTIVHFEDAFIELA
CCHHHEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEVGGIEGLTAYEVRQYIRYIADRRLMQLGLKDVYLVNHNPLPWLDEMLNGVEHTNFFEN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
RATEYSKAATTGSWEEVFTQMDAKRGG
HHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]