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The map label for this gene is uvrD [H]

Identifier: 157825751

GI number: 157825751

Start: 610162

End: 612123

Strand: Direct

Name: uvrD [H]

Synonym: A1C_03385

Alternate gene names: 157825751

Gene position: 610162-612123 (Clockwise)

Preceding gene: 157825750

Following gene: 157825752

Centisome position: 49.56

GC content: 33.49

Gene sequence:

>1962_bases
ATGCAAGATCAAGATTTCATACATACATTAAATCCACAACAGCAAAAAGCAGTTCTTCATACTGAAGGACCGCTTTTATT
GCTTGCAGGTGCAGGGACAGGTAAAACAAAAGTACTTACCTCAAGAATAGCTAATATTATTCACAAAAATTTAGCCCCAC
CTCAAAATATTCTAGCCGTTACTTTCACTAATAAGGCTGCTAAAGAAATGGCTGAAAGAGTGAACAGTCTAATTAATTGC
TACGGTCTTAATATAGGCACTTTCCACTCAATGGCAGCTAGGATATTACGTGACCAAAGTGAGCATTTAAATCTTGGTTT
AAATAATAGATTTACTATTATTAGTCATGATGATCAATTAAAATTAGTTAAGGATATAGTAAAACTAAAAGATATTGATA
CTAAAAAATATGCTCCTAAATTAATACATATAATAATTTCGAGATGGAAGGATCAAGGATTATTACCAAGTAAATTATCA
GCATCAGATACTAATTTACCGCTGCAGAGGGTGGCAAAACTTGTATACGAAGAATATCAGAAAAATTTACTTATTTCTAA
TGTTTTAGATTTTGGAGATTTGCTACTTTATAATAATGAGCTTTTTATTAAAAATCCCGCAATACTAAGATATTACCAGG
AAAAATATCGATATATTTTAATCGATGAATATCAAGACACTAACGTTGTCCAATATTTATGGGCAAGAATGCTCGCAAGT
TTATATAAAAATATTTGCTGTGTAGGAGATGATGATCAATCTATCTATGGTTGGCGAGGAGCAGAAGTCGGGAATATATT
ACGTTTTGAAAAAGATTTTGCAGGTGCAACGATTATTAAATTAGAGCAGAATTATAGATCAACTTTGCCAATACTTGCTG
CTGCCTCTAATGTAATCAATAATAATAAAAACCGTCACGGTAAAACGTTATGGACAGATAAGGAAAGCGGTGAAAAGATA
AAAATTATCTCTTGTTGGAGTGATAAAGAAGAAGCAAGATATATAGCCAGTGAAATAGATAAGTTAGTGAGAGAAGAGCG
ATATAATGCTGGCAATATTGCAATATTAGTACGAGCCGGATTTCAAACAAGAAGTTTTGAGGAAGCGTTTATAAATAGTG
CTATGCCTTATAAAATTATAGGAGGTGTGCGGTTCTATGAACGTATCGAAATAAGAGACGTGCTTGCTTATATTCGTATA
TCTTTGAATCAAAATGACAATCTAGCACTTGAGCGTATTATAAATGTGCCGAAAAGGGCAATAGGTGCAGCTAGCTTAAA
TAAAATTAGATTATATGCACTTGAGCGAAATATTTCTAATTTCGCATCCATTAAAGAAATGTTAGAAATGGGCGAGATTA
AAGCAAAACAATATGAAACTCTAAAAGATTTGGTTACTAAAATTGATAATTGGCACGAAATATTTAATATAGATGCTCCA
ATAAACGTAGTTAAAGCAATACTTGATGATTCCGGTTATCTTGAAATGCTTCAAGAAGAAAAGACCGAAGAAGCATTCGG
TAGAATCGAAAATATTAACGAAATGCTTAAAGCTATTGCCGAATTTAACGATGCTCATGATTTTATCGAACATTCAAGTT
TAGTTATGGAAAATGAAGTGCTTGAAACTAATTACGGTGGTGCTGTTACTATAATGACCTTGCACGCAGCTAAAGGGCTT
GAGTTTGACGTAGTGTTTTTACCGGGATGGGAAGAGGGGCTATTTCCGTCTCAAAGGTCTCTAGACAAAGACGGCGAAAA
AGGCTTAGAAGAAGAACGCCGCATTGCTTATGTCGGTATTACGAGAGCCAAAAAAGACCTATACATTACCCACGCCGAAA
GCAGAAAAATATTTTATGAAATAGTACGCTCTTACCCTTCAAGGTTTATAACAGAAATCCCTGATGAAATTACGATTAGG
ACCTCTTCTATGAAAAAATACAATTCTTTTTATAAGTTTTAA

Upstream 100 bases:

>100_bases
TTTTTACTGGATTGCTTCGTCAATTATTTTGTCCTTTCCTCGCAATAACGGAAAATCGAGCCATGGGATGACAACCAATT
TACAACACATTTAAAAACAA

Downstream 100 bases:

>100_bases
TTAATTTTCATTCATAAATTTTAAATTGGTTTGCATACTTTAACTAATTGTTATCTAATTTAATTAATAATAATTAACAT
AGGAAGTGGTATGGCCAAGG

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MQDQDFIHTLNPQQQKAVLHTEGPLLLLAGAGTGKTKVLTSRIANIIHKNLAPPQNILAVTFTNKAAKEMAERVNSLINC
YGLNIGTFHSMAARILRDQSEHLNLGLNNRFTIISHDDQLKLVKDIVKLKDIDTKKYAPKLIHIIISRWKDQGLLPSKLS
ASDTNLPLQRVAKLVYEEYQKNLLISNVLDFGDLLLYNNELFIKNPAILRYYQEKYRYILIDEYQDTNVVQYLWARMLAS
LYKNICCVGDDDQSIYGWRGAEVGNILRFEKDFAGATIIKLEQNYRSTLPILAAASNVINNNKNRHGKTLWTDKESGEKI
KIISCWSDKEEARYIASEIDKLVREERYNAGNIAILVRAGFQTRSFEEAFINSAMPYKIIGGVRFYERIEIRDVLAYIRI
SLNQNDNLALERIINVPKRAIGAASLNKIRLYALERNISNFASIKEMLEMGEIKAKQYETLKDLVTKIDNWHEIFNIDAP
INVVKAILDDSGYLEMLQEEKTEEAFGRIENINEMLKAIAEFNDAHDFIEHSSLVMENEVLETNYGGAVTIMTLHAAKGL
EFDVVFLPGWEEGLFPSQRSLDKDGEKGLEEERRIAYVGITRAKKDLYITHAESRKIFYEIVRSYPSRFITEIPDEITIR
TSSMKKYNSFYKF

Sequences:

>Translated_653_residues
MQDQDFIHTLNPQQQKAVLHTEGPLLLLAGAGTGKTKVLTSRIANIIHKNLAPPQNILAVTFTNKAAKEMAERVNSLINC
YGLNIGTFHSMAARILRDQSEHLNLGLNNRFTIISHDDQLKLVKDIVKLKDIDTKKYAPKLIHIIISRWKDQGLLPSKLS
ASDTNLPLQRVAKLVYEEYQKNLLISNVLDFGDLLLYNNELFIKNPAILRYYQEKYRYILIDEYQDTNVVQYLWARMLAS
LYKNICCVGDDDQSIYGWRGAEVGNILRFEKDFAGATIIKLEQNYRSTLPILAAASNVINNNKNRHGKTLWTDKESGEKI
KIISCWSDKEEARYIASEIDKLVREERYNAGNIAILVRAGFQTRSFEEAFINSAMPYKIIGGVRFYERIEIRDVLAYIRI
SLNQNDNLALERIINVPKRAIGAASLNKIRLYALERNISNFASIKEMLEMGEIKAKQYETLKDLVTKIDNWHEIFNIDAP
INVVKAILDDSGYLEMLQEEKTEEAFGRIENINEMLKAIAEFNDAHDFIEHSSLVMENEVLETNYGGAVTIMTLHAAKGL
EFDVVFLPGWEEGLFPSQRSLDKDGEKGLEEERRIAYVGITRAKKDLYITHAESRKIFYEIVRSYPSRFITEIPDEITIR
TSSMKKYNSFYKF
>Mature_653_residues
MQDQDFIHTLNPQQQKAVLHTEGPLLLLAGAGTGKTKVLTSRIANIIHKNLAPPQNILAVTFTNKAAKEMAERVNSLINC
YGLNIGTFHSMAARILRDQSEHLNLGLNNRFTIISHDDQLKLVKDIVKLKDIDTKKYAPKLIHIIISRWKDQGLLPSKLS
ASDTNLPLQRVAKLVYEEYQKNLLISNVLDFGDLLLYNNELFIKNPAILRYYQEKYRYILIDEYQDTNVVQYLWARMLAS
LYKNICCVGDDDQSIYGWRGAEVGNILRFEKDFAGATIIKLEQNYRSTLPILAAASNVINNNKNRHGKTLWTDKESGEKI
KIISCWSDKEEARYIASEIDKLVREERYNAGNIAILVRAGFQTRSFEEAFINSAMPYKIIGGVRFYERIEIRDVLAYIRI
SLNQNDNLALERIINVPKRAIGAASLNKIRLYALERNISNFASIKEMLEMGEIKAKQYETLKDLVTKIDNWHEIFNIDAP
INVVKAILDDSGYLEMLQEEKTEEAFGRIENINEMLKAIAEFNDAHDFIEHSSLVMENEVLETNYGGAVTIMTLHAAKGL
EFDVVFLPGWEEGLFPSQRSLDKDGEKGLEEERRIAYVGITRAKKDLYITHAESRKIFYEIVRSYPSRFITEIPDEITIR
TSSMKKYNSFYKF

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=644, Percent_Identity=41.304347826087, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI48994965, Length=648, Percent_Identity=38.4259259259259, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=26.7647058823529, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322369, Length=519, Percent_Identity=31.9845857418112, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324477, Length=676, Percent_Identity=23.0769230769231, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 74920; Mature: 74920

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDQDFIHTLNPQQQKAVLHTEGPLLLLAGAGTGKTKVLTSRIANIIHKNLAPPQNILAV
CCCCCCEECCCCCHHCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
TFTNKAAKEMAERVNSLINCYGLNIGTFHSMAARILRDQSEHLNLGLNNRFTIISHDDQL
EECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCCCCCCCEEEEEECCCHH
KLVKDIVKLKDIDTKKYAPKLIHIIISRWKDQGLLPSKLSASDTNLPLQRVAKLVYEEYQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KNLLISNVLDFGDLLLYNNELFIKNPAILRYYQEKYRYILIDEYQDTNVVQYLWARMLAS
HHHHHHHHHHHCCEEEECCEEEEECHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
LYKNICCVGDDDQSIYGWRGAEVGNILRFEKDFAGATIIKLEQNYRSTLPILAAASNVIN
HHHCEEEECCCCCCEECCCCCCCCHHHHHHHCCCCEEEEEEECCCHHCCHHHHHHHHHHC
NNKNRHGKTLWTDKESGEKIKIISCWSDKEEARYIASEIDKLVREERYNAGNIAILVRAG
CCCCCCCCEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
FQTRSFEEAFINSAMPYKIIGGVRFYERIEIRDVLAYIRISLNQNDNLALERIINVPKRA
CCCCCHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCHHH
IGAASLNKIRLYALERNISNFASIKEMLEMGEIKAKQYETLKDLVTKIDNWHEIFNIDAP
HCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCH
INVVKAILDDSGYLEMLQEEKTEEAFGRIENINEMLKAIAEFNDAHDFIEHSSLVMENEV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
LETNYGGAVTIMTLHAAKGLEFDVVFLPGWEEGLFPSQRSLDKDGEKGLEEERRIAYVGI
HCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHCEEEEEEE
TRAKKDLYITHAESRKIFYEIVRSYPSRFITEIPDEITIRTSSMKKYNSFYKF
EECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure
MQDQDFIHTLNPQQQKAVLHTEGPLLLLAGAGTGKTKVLTSRIANIIHKNLAPPQNILAV
CCCCCCEECCCCCHHCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
TFTNKAAKEMAERVNSLINCYGLNIGTFHSMAARILRDQSEHLNLGLNNRFTIISHDDQL
EECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCCCCCCCEEEEEECCCHH
KLVKDIVKLKDIDTKKYAPKLIHIIISRWKDQGLLPSKLSASDTNLPLQRVAKLVYEEYQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KNLLISNVLDFGDLLLYNNELFIKNPAILRYYQEKYRYILIDEYQDTNVVQYLWARMLAS
HHHHHHHHHHHCCEEEECCEEEEECHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
LYKNICCVGDDDQSIYGWRGAEVGNILRFEKDFAGATIIKLEQNYRSTLPILAAASNVIN
HHHCEEEECCCCCCEECCCCCCCCHHHHHHHCCCCEEEEEEECCCHHCCHHHHHHHHHHC
NNKNRHGKTLWTDKESGEKIKIISCWSDKEEARYIASEIDKLVREERYNAGNIAILVRAG
CCCCCCCCEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
FQTRSFEEAFINSAMPYKIIGGVRFYERIEIRDVLAYIRISLNQNDNLALERIINVPKRA
CCCCCHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCHHH
IGAASLNKIRLYALERNISNFASIKEMLEMGEIKAKQYETLKDLVTKIDNWHEIFNIDAP
HCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCH
INVVKAILDDSGYLEMLQEEKTEEAFGRIENINEMLKAIAEFNDAHDFIEHSSLVMENEV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
LETNYGGAVTIMTLHAAKGLEFDVVFLPGWEEGLFPSQRSLDKDGEKGLEEERRIAYVGI
HCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHCEEEEEEE
TRAKKDLYITHAESRKIFYEIVRSYPSRFITEIPDEITIRTSSMKKYNSFYKF
EECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]