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The map label for this gene is dapA [H]

Identifier: 157825714

GI number: 157825714

Start: 583124

End: 584008

Strand: Direct

Name: dapA [H]

Synonym: A1C_03200

Alternate gene names: 157825714

Gene position: 583124-584008 (Clockwise)

Preceding gene: 157825713

Following gene: 157825715

Centisome position: 47.37

GC content: 33.33

Gene sequence:

>885_bases
ATGAATAACATATTTAAAGGTTTAATTACCGCACTTATAACACCTTTTAAAGATAATAAGTTAGACTTATATGCTTTAGA
GAGAATTTTAAAACATCAAATAAAGCATGATGTCGATGCAATATTAATTGCAGGTTCAACCGGAGAAGGTAGTAGTTTGA
GTTTTGAAGAATATAAATTATTACTGCAAACTAGCGTAGAAATCGTTAATAAGCGTATTCCTATAATAAGCGGATGTTCA
TCAAATAATACCGCTTATGCAATAGAACTGGCAGCGGAATCTACAAAAATCAAAGTTGATGGTTTTATGGCTAGTCCACC
ATCTTATGTAAAACCTACACAACACGGGATTTATAAGCATTTTGAAGCATTACATGAAGCGTGTAATCTACCTATTATAT
TATATTCAGCTCCCACTAGAAGCGGAGTAGATTTTTCTGATGAGACGATATTGAGGCTTAGCGCGCTAACGCGTATCTTA
GCATTAAAAGATTGCGGCGTAGATTTAGGACGTCCATTGCGTATTAGAGCAATAGTTAAAAAGGATTTTAATATTTTAAC
CGGTAATGATGAAGTAGTTTTAGCTTTTAATGCACAAGGTGGGGTAGGGTGGACTGCTGTAGCCTCTAATATTGCTCCCG
ATATGTGTAAAGAGTTATTAGAGAAGTGGTATAAGAATGATACTAAAGGAGCATTAGAAATCCATCAGAAATTACTGCCT
TTATATAAAGCTTTGTTTCTAGAATCTAATCCGATTCCAATAAAATATGCCGCTCATTATTTAGGTTTATGTGAAAATGA
AATTAGACCTCCATTAACTGAAGCAAGCGATAGTGCTAAAAAACAAATTGAAAACATTATAACAGCACTATCTATAAAAA
TATGA

Upstream 100 bases:

>100_bases
TTAATCCAGTGATTAAGTCGTGGGATAACAAATTAGGAAGCTGAACCATGAGGCAAATGCTTCCTCACAATGACAAATTA
ATAAAAAATAAAAAACAAAA

Downstream 100 bases:

>100_bases
CCGAATATAAGAAAGTTATTGCACAAAATAATAAAGCCATTTTTAATTATTTTATTGAAGAAAGATTAGAAGCAGGTATT
GTATTAAATGGGAGTGAAGT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNNIFKGLITALITPFKDNKLDLYALERILKHQIKHDVDAILIAGSTGEGSSLSFEEYKLLLQTSVEIVNKRIPIISGCS
SNNTAYAIELAAESTKIKVDGFMASPPSYVKPTQHGIYKHFEALHEACNLPIILYSAPTRSGVDFSDETILRLSALTRIL
ALKDCGVDLGRPLRIRAIVKKDFNILTGNDEVVLAFNAQGGVGWTAVASNIAPDMCKELLEKWYKNDTKGALEIHQKLLP
LYKALFLESNPIPIKYAAHYLGLCENEIRPPLTEASDSAKKQIENIITALSIKI

Sequences:

>Translated_294_residues
MNNIFKGLITALITPFKDNKLDLYALERILKHQIKHDVDAILIAGSTGEGSSLSFEEYKLLLQTSVEIVNKRIPIISGCS
SNNTAYAIELAAESTKIKVDGFMASPPSYVKPTQHGIYKHFEALHEACNLPIILYSAPTRSGVDFSDETILRLSALTRIL
ALKDCGVDLGRPLRIRAIVKKDFNILTGNDEVVLAFNAQGGVGWTAVASNIAPDMCKELLEKWYKNDTKGALEIHQKLLP
LYKALFLESNPIPIKYAAHYLGLCENEIRPPLTEASDSAKKQIENIITALSIKI
>Mature_294_residues
MNNIFKGLITALITPFKDNKLDLYALERILKHQIKHDVDAILIAGSTGEGSSLSFEEYKLLLQTSVEIVNKRIPIISGCS
SNNTAYAIELAAESTKIKVDGFMASPPSYVKPTQHGIYKHFEALHEACNLPIILYSAPTRSGVDFSDETILRLSALTRIL
ALKDCGVDLGRPLRIRAIVKKDFNILTGNDEVVLAFNAQGGVGWTAVASNIAPDMCKELLEKWYKNDTKGALEIHQKLLP
LYKALFLESNPIPIKYAAHYLGLCENEIRPPLTEASDSAKKQIENIITALSIKI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=287, Percent_Identity=21.602787456446, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788823, Length=288, Percent_Identity=34.0277777777778, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI87082415, Length=296, Percent_Identity=29.7297297297297, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786463, Length=252, Percent_Identity=28.1746031746032, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789620, Length=210, Percent_Identity=29.5238095238095, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32464; Mature: 32464

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNIFKGLITALITPFKDNKLDLYALERILKHQIKHDVDAILIAGSTGEGSSLSFEEYKL
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHH
LLQTSVEIVNKRIPIISGCSSNNTAYAIELAAESTKIKVDGFMASPPSYVKPTQHGIYKH
HHHHHHHHHHCCCCEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHH
FEALHEACNLPIILYSAPTRSGVDFSDETILRLSALTRILALKDCGVDLGRPLRIRAIVK
HHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
KDFNILTGNDEVVLAFNAQGGVGWTAVASNIAPDMCKELLEKWYKNDTKGALEIHQKLLP
CCCEEEECCCCEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LYKALFLESNPIPIKYAAHYLGLCENEIRPPLTEASDSAKKQIENIITALSIKI
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNIFKGLITALITPFKDNKLDLYALERILKHQIKHDVDAILIAGSTGEGSSLSFEEYKL
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHH
LLQTSVEIVNKRIPIISGCSSNNTAYAIELAAESTKIKVDGFMASPPSYVKPTQHGIYKH
HHHHHHHHHHCCCCEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHH
FEALHEACNLPIILYSAPTRSGVDFSDETILRLSALTRILALKDCGVDLGRPLRIRAIVK
HHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
KDFNILTGNDEVVLAFNAQGGVGWTAVASNIAPDMCKELLEKWYKNDTKGALEIHQKLLP
CCCEEEECCCCEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LYKALFLESNPIPIKYAAHYLGLCENEIRPPLTEASDSAKKQIENIITALSIKI
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA