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The map label for this gene is dut [H]

Identifier: 157825674

GI number: 157825674

Start: 537731

End: 538177

Strand: Direct

Name: dut [H]

Synonym: A1C_02980

Alternate gene names: 157825674

Gene position: 537731-538177 (Clockwise)

Preceding gene: 157825673

Following gene: 157825675

Centisome position: 43.68

GC content: 37.58

Gene sequence:

>447_bases
ATGAATATAACGCAAGTTAAAATTAAGAAATTAGAAAATTTTTCAGGTAGTTTGCCGGAATATGCTACAGAGCATAGTGC
TGGGATGGATTTAATAGCCGCAAATGAGCAACCTATAACAATAAAAGCAGGTGAAATACAGCTAATTCCAACCGGTATCG
CTATAGCATTACCTTACTCATTTGAAGCACAGATAAGACCTCGTTCGGGTCTTGCAGTTAAACACGGTATTACGGTTGCT
AATTCACCTGGTACTATTGATGCAGATTATAGAGGCGAAATAAAGGTGATTCTTATTAATCTTGGTACACAAGATTTCGT
TATAGAAAAAGGGATGCGAATTGCTCAGATCATAATATCCAAGTACGAACGTATATTATGGGAAGAAAGTAGTATCCTTA
CGGAAACGATGCGTGGTAGCGGTGGTTTTGGTTCTACTGGTGTTTAA

Upstream 100 bases:

>100_bases
TGCTCGCGTACTTTTGTACGCTCCGCTCCTCGGCGTGCAAACTCATTGCTCTTTTCCAAGTTGATCTTCGTATATCAACT
CTTCACGTATGAGAAAGATT

Downstream 100 bases:

>100_bases
GGATTCTAAAAACGTTATTGCAAGTGGGTATTGCCCTAATCGTCATTGCGAGCGACCGTAGGGAGCGTGGCAATCTAGAG
CAAGATTTAAAAAATTCTAT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MNITQVKIKKLENFSGSLPEYATEHSAGMDLIAANEQPITIKAGEIQLIPTGIAIALPYSFEAQIRPRSGLAVKHGITVA
NSPGTIDADYRGEIKVILINLGTQDFVIEKGMRIAQIIISKYERILWEESSILTETMRGSGGFGSTGV

Sequences:

>Translated_148_residues
MNITQVKIKKLENFSGSLPEYATEHSAGMDLIAANEQPITIKAGEIQLIPTGIAIALPYSFEAQIRPRSGLAVKHGITVA
NSPGTIDADYRGEIKVILINLGTQDFVIEKGMRIAQIIISKYERILWEESSILTETMRGSGGFGSTGV
>Mature_148_residues
MNITQVKIKKLENFSGSLPEYATEHSAGMDLIAANEQPITIKAGEIQLIPTGIAIALPYSFEAQIRPRSGLAVKHGITVA
NSPGTIDADYRGEIKVILINLGTQDFVIEKGMRIAQIIISKYERILWEESSILTETMRGSGGFGSTGV

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=146, Percent_Identity=43.1506849315069, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI70906441, Length=146, Percent_Identity=43.1506849315069, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI4503423, Length=146, Percent_Identity=43.1506849315069, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1790071, Length=149, Percent_Identity=38.255033557047, Blast_Score=98, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988561, Length=147, Percent_Identity=42.1768707482993, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319729, Length=152, Percent_Identity=41.4473684210526, Blast_Score=98, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24583610, Length=133, Percent_Identity=37.593984962406, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921126, Length=133, Percent_Identity=37.593984962406, Blast_Score=80, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16033; Mature: 16033

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITQVKIKKLENFSGSLPEYATEHSAGMDLIAANEQPITIKAGEIQLIPTGIAIALPYS
CCCCHHHHHHHHCCCCCCCCHHHHCCCCCEEEECCCCCEEEECCEEEEEECCEEEEECCC
FEAQIRPRSGLAVKHGITVANSPGTIDADYRGEIKVILINLGTQDFVIEKGMRIAQIIIS
CEEEECCCCCCEEECCEEEECCCCEECCCCCCCEEEEEEECCCCHHHHHCCCHHHHHHHH
KYERILWEESSILTETMRGSGGFGSTGV
HHHHHHHCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNITQVKIKKLENFSGSLPEYATEHSAGMDLIAANEQPITIKAGEIQLIPTGIAIALPYS
CCCCHHHHHHHHCCCCCCCCHHHHCCCCCEEEECCCCCEEEECCEEEEEECCEEEEECCC
FEAQIRPRSGLAVKHGITVANSPGTIDADYRGEIKVILINLGTQDFVIEKGMRIAQIIIS
CEEEECCCCCCEEECCEEEECCCCEECCCCCCCEEEEEEECCCCHHHHHCCCHHHHHHHH
KYERILWEESSILTETMRGSGGFGSTGV
HHHHHHHCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA