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The map label for this gene is nhaA [H]

Identifier: 157825673

GI number: 157825673

Start: 536661

End: 537575

Strand: Direct

Name: nhaA [H]

Synonym: A1C_02975

Alternate gene names: 157825673

Gene position: 536661-537575 (Clockwise)

Preceding gene: 157825672

Following gene: 157825674

Centisome position: 43.59

GC content: 31.91

Gene sequence:

>915_bases
ATGAATGAAGTAAATAAATCAACTATGGCGAATGCAGAATTTGATAAGATAATAACCAAACGGCAGATAAGTAAATTAGA
TCAATTATTTGCTTCGGTTTTTGGTGATTCTAAAGAAGTGATTGCCGTGTTACGCCTTAGCGGTGTTATCGGTAAAGTAA
GTACTATGCAATCTGGACTTACTTTAGAATCATTAAATGAACTAATAGAAAAAGCTTTTAAAATAAAGAAATTAAAAGCA
TTATGTTTAATTATTAATTCTCCTGGGGGTTCTCCGGTACAATCTGAACTTATTGCGAAACGTATTCGTGACCTTGCTAA
AGAAAATAAAATAAAAATTTATAGTTTTATTGAAGATATGGCGGCTTCAGGCGGATATTTGCTTGCTTGCAGCGGTGACT
GGATATATGCTTCTTATAGTTCGGTGATAGGTAGTATTGGAGTAGTGTCAAGCGGATTCGGTTTCCATGAAGCGATTAAT
AAACTTGGAATAGAGCGTAGAGTTTATACGGAAGGAAAAAATAAAGCAATTTTAGATCCTTTTAAACCTATTAATAAAGA
GGATCTTAAAATTATCAAAGATTTGCAAAAGCATGTTTACGAGCATTTTGTAGAATATGTAAAAACAAGAAGAGTAGGGA
AGTTAACACAGCAAGACGAGATTTTATTTAACGGTGAATTTTGGGCAGGACAAACTGCTCTTGATTACGGTTTAATTGAC
GGCATAGGTGATATGTATAGCATAATGAAAGAAAAATTCGGCGATAATATTAAGTTTCAATATCTGTGTGCTAAACAGCA
TTGGCTTAAAAAGAAACTTGGTATGTGCAGTAAGATATTAAGCGATAATCTTGCTAATTCTTTAATTGATGCGATAGAAA
ATAAAATTATTAACGATAAATTTGATATAAAATAA

Upstream 100 bases:

>100_bases
TATCCTGAACCTAAAAATAGTTATAATGAGCAATCTCTGAATAAATCGGCTAAGCCTTTGCCGCCAATAAAAAAGGATAT
AATTAAAAACGAGCAGAATA

Downstream 100 bases:

>100_bases
ATATACTAAGATAGAACTTGAAAAATTGGCGACAATATCTTTGTAAGTCCTCGGATGCTCGCGTACTTTTGTACGCTCCG
CTCCTCGGCGTGCAAACTCA

Product: Signal peptide peptidase SppA

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNEVNKSTMANAEFDKIITKRQISKLDQLFASVFGDSKEVIAVLRLSGVIGKVSTMQSGLTLESLNELIEKAFKIKKLKA
LCLIINSPGGSPVQSELIAKRIRDLAKENKIKIYSFIEDMAASGGYLLACSGDWIYASYSSVIGSIGVVSSGFGFHEAIN
KLGIERRVYTEGKNKAILDPFKPINKEDLKIIKDLQKHVYEHFVEYVKTRRVGKLTQQDEILFNGEFWAGQTALDYGLID
GIGDMYSIMKEKFGDNIKFQYLCAKQHWLKKKLGMCSKILSDNLANSLIDAIENKIINDKFDIK

Sequences:

>Translated_304_residues
MNEVNKSTMANAEFDKIITKRQISKLDQLFASVFGDSKEVIAVLRLSGVIGKVSTMQSGLTLESLNELIEKAFKIKKLKA
LCLIINSPGGSPVQSELIAKRIRDLAKENKIKIYSFIEDMAASGGYLLACSGDWIYASYSSVIGSIGVVSSGFGFHEAIN
KLGIERRVYTEGKNKAILDPFKPINKEDLKIIKDLQKHVYEHFVEYVKTRRVGKLTQQDEILFNGEFWAGQTALDYGLID
GIGDMYSIMKEKFGDNIKFQYLCAKQHWLKKKLGMCSKILSDNLANSLIDAIENKIINDKFDIK
>Mature_304_residues
MNEVNKSTMANAEFDKIITKRQISKLDQLFASVFGDSKEVIAVLRLSGVIGKVSTMQSGLTLESLNELIEKAFKIKKLKA
LCLIINSPGGSPVQSELIAKRIRDLAKENKIKIYSFIEDMAASGGYLLACSGDWIYASYSSVIGSIGVVSSGFGFHEAIN
KLGIERRVYTEGKNKAILDPFKPINKEDLKIIKDLQKHVYEHFVEYVKTRRVGKLTQQDEILFNGEFWAGQTALDYGLID
GIGDMYSIMKEKFGDNIKFQYLCAKQHWLKKKLGMCSKILSDNLANSLIDAIENKIINDKFDIK

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=266, Percent_Identity=27.0676691729323, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787527, Length=236, Percent_Identity=26.6949152542373, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 34096; Mature: 34096

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00264 NEUROHYPOPHYS_HORM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEVNKSTMANAEFDKIITKRQISKLDQLFASVFGDSKEVIAVLRLSGVIGKVSTMQSGL
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
TLESLNELIEKAFKIKKLKALCLIINSPGGSPVQSELIAKRIRDLAKENKIKIYSFIEDM
CHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AASGGYLLACSGDWIYASYSSVIGSIGVVSSGFGFHEAINKLGIERRVYTEGKNKAILDP
HCCCCEEEEECCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHEEECCCCCEECCC
FKPINKEDLKIIKDLQKHVYEHFVEYVKTRRVGKLTQQDEILFNGEFWAGQTALDYGLID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHH
GIGDMYSIMKEKFGDNIKFQYLCAKQHWLKKKLGMCSKILSDNLANSLIDAIENKIINDK
HHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FDIK
CCCC
>Mature Secondary Structure
MNEVNKSTMANAEFDKIITKRQISKLDQLFASVFGDSKEVIAVLRLSGVIGKVSTMQSGL
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
TLESLNELIEKAFKIKKLKALCLIINSPGGSPVQSELIAKRIRDLAKENKIKIYSFIEDM
CHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AASGGYLLACSGDWIYASYSSVIGSIGVVSSGFGFHEAINKLGIERRVYTEGKNKAILDP
HCCCCEEEEECCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHEEECCCCCEECCC
FKPINKEDLKIIKDLQKHVYEHFVEYVKTRRVGKLTQQDEILFNGEFWAGQTALDYGLID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHH
GIGDMYSIMKEKFGDNIKFQYLCAKQHWLKKKLGMCSKILSDNLANSLIDAIENKIINDK
HHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FDIK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA