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The map label for this gene is ptrB [H]

Identifier: 157825499

GI number: 157825499

Start: 374457

End: 376511

Strand: Reverse

Name: ptrB [H]

Synonym: A1C_02000

Alternate gene names: 157825499

Gene position: 376511-374457 (Counterclockwise)

Preceding gene: 157825500

Following gene: 157825498

Centisome position: 30.58

GC content: 31.63

Gene sequence:

>2055_bases
ATGAAACCACCCATAGCAAATAAACAAAATTACAGCTTTAAAGCCCACGGACAAACAATAAACGATTATTATCAATGGCT
GCGTGATCCTAAATGGCCAAATGTAGCAGACTCTAAAATTTTAGATTACTTAAAAGCCGAGAATAAATATACCGAAAATT
TCTTTTCCGATCTACAAAAGGATAAGGAAAAGATTTTTGAAGAATTAAGAGGACGAGTCAAATTAGACGATGAATCGGTA
TACATTAAGAAAAAAGATTATTACTATTACCATAGAGTAGTATGGAATAAAAATTATCCTATATATTGCCGGAAGCATAA
TAGTATGGAAGCAGAAGAAGAAGTAATATTAGATGTTAACCTTCTTGCTTCAAATAGTGGTTTTACCGATGTTGCTAAGA
TTGCAATGTCACCTGATCAAACTTTAATATCTTATAGCGTTGATTTTACAGGTAATGAGCAATACAATATCAAAATATAC
AATCTTAAAGAACAAAAATACTTACCTGATGAAGTACAGGATGTTGCTCCTACTGTGATTTGGCATGAACAACTAAACGG
CTTTTTCTATATTACTATTAATGAGAATCAACGCTGGGATAAGATAATGTTCCATCGTTTAGGGGAAGATATTACTCAGG
ACAAATTAATATTCGAGGTAAAAAACCCTCTTCATTTTATCAGCTGCAAGAAATCAGCAAGTCATGAATATATTTTTATA
AATTCAGGCGATCATAATGAAAATGAAATTTACGTAATTTCTATGCAGGATGATAGTTTTACGCCTAAATTAGTACGAGC
CGCAGAAAATAAAATATTCTATGACATAGAACATAATGGCGATTATTTTTATATTAAAACTAATTATAAAGCTAAAAATT
TCCATGCTGTAAAACTGCCGATAAATAATTTTGAAAATACTAGCTGGGATGATATTTATATTAAAGAAGAACAGGACAAA
TATTTAAAAAGCTTTGATGTTACAAATAATTATTTAATCTTAAATTATCGTGACCAAGGTTTACCGCTAATTAAAATAAA
GCAATTTAACAATTTACAAGAAAAAATAATTCACTTTCATGACGAGAGTTTCCAAGCAAATAGTTTTTCTACAAACTTTG
AGGAAGACGATATCAGAGTAGACTACTCTTCTCTAGCAATACCAAATACCACTTATAGCTACGATTTTGATAACAATGCA
TTAGTGATATTAAAGACCCAAGAAATACCTTCAGGATTTAATACGAAAGAATATAAAGTAGAGAGAATATTTGCAGATAA
TGAAGATGTAAAAGTACCTATCACCTTGTTTTATAAAAAATCTTTATTTAAAAAAGATGGCTCAAATCCTTTATATTTAA
TGGGTTACGGAGCTTACGGGATTAGCATGCCTGTTAATTTTAGCAACATGGCAGTAACGCTTGCAAATCGTGGTTTTATT
TATGCGGTTGTGCATATTAGAGGCGGCGATGATTTAGGTCATGATTGGTATGAATCAGCTAAGTTTTTAACTAAAAAAAG
AACCTTTGAAGATTTTATAGCGTGTAGTAGAGCTTTAATTAAAGAAAAATATACAAGTAACAACAATATAGTAATAATGG
GCTGTAGTGCCGGCGGTATGTTAATCGGTTACGTACTAAACGAAAAACCAGAAATTTATAGAGCGGCAGTCGCTCATGTA
CCATTTGTTGATGTTTTGAGTACCATGCTTGATGAACGCTTACCGTTAACTCTCTTGGAATATAATGAATGGGGTAATCC
GAAAGAGAAAGAATATTTTGAATATATTAAATCATATTCCCCTTATGATAACGTAAAAGTACAAGACTACCCTGCTATAT
TCATTACTTGTGGTATATCCGACCCACGAGTCGGTTACTGGGAACCGGCTAAATGGGTAGCAAAATTACGGGATCTAAAA
ACTGACAATAATCCTTTATTATTAAAAACAAATATGGATACAGGGCATAAAGGTTCCGTCGGTCGCTTTGATTATTTGAA
AGAGATAACTGACGAATTAGTATTTATTTTTAAGATCTTTGATGTGAAGGTTTAA

Upstream 100 bases:

>100_bases
ACTGCTATATTTATTGTATTATTTCTATTAATTGGTTTGATTTTAACACTCTGTCATACTATGGCTTGACCACGGTATGA
CACTCAAAACAATAAAAAAC

Downstream 100 bases:

>100_bases
AGATTTTATTGTAATCCCGCGACTTGATCGCGGGATCCAAAAAAACATAAACAAGACTTGATACCGTTGACAAGCCACAG
TATGACAGAATAAATATAAA

Product: protease II

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MKPPIANKQNYSFKAHGQTINDYYQWLRDPKWPNVADSKILDYLKAENKYTENFFSDLQKDKEKIFEELRGRVKLDDESV
YIKKKDYYYYHRVVWNKNYPIYCRKHNSMEAEEEVILDVNLLASNSGFTDVAKIAMSPDQTLISYSVDFTGNEQYNIKIY
NLKEQKYLPDEVQDVAPTVIWHEQLNGFFYITINENQRWDKIMFHRLGEDITQDKLIFEVKNPLHFISCKKSASHEYIFI
NSGDHNENEIYVISMQDDSFTPKLVRAAENKIFYDIEHNGDYFYIKTNYKAKNFHAVKLPINNFENTSWDDIYIKEEQDK
YLKSFDVTNNYLILNYRDQGLPLIKIKQFNNLQEKIIHFHDESFQANSFSTNFEEDDIRVDYSSLAIPNTTYSYDFDNNA
LVILKTQEIPSGFNTKEYKVERIFADNEDVKVPITLFYKKSLFKKDGSNPLYLMGYGAYGISMPVNFSNMAVTLANRGFI
YAVVHIRGGDDLGHDWYESAKFLTKKRTFEDFIACSRALIKEKYTSNNNIVIMGCSAGGMLIGYVLNEKPEIYRAAVAHV
PFVDVLSTMLDERLPLTLLEYNEWGNPKEKEYFEYIKSYSPYDNVKVQDYPAIFITCGISDPRVGYWEPAKWVAKLRDLK
TDNNPLLLKTNMDTGHKGSVGRFDYLKEITDELVFIFKIFDVKV

Sequences:

>Translated_684_residues
MKPPIANKQNYSFKAHGQTINDYYQWLRDPKWPNVADSKILDYLKAENKYTENFFSDLQKDKEKIFEELRGRVKLDDESV
YIKKKDYYYYHRVVWNKNYPIYCRKHNSMEAEEEVILDVNLLASNSGFTDVAKIAMSPDQTLISYSVDFTGNEQYNIKIY
NLKEQKYLPDEVQDVAPTVIWHEQLNGFFYITINENQRWDKIMFHRLGEDITQDKLIFEVKNPLHFISCKKSASHEYIFI
NSGDHNENEIYVISMQDDSFTPKLVRAAENKIFYDIEHNGDYFYIKTNYKAKNFHAVKLPINNFENTSWDDIYIKEEQDK
YLKSFDVTNNYLILNYRDQGLPLIKIKQFNNLQEKIIHFHDESFQANSFSTNFEEDDIRVDYSSLAIPNTTYSYDFDNNA
LVILKTQEIPSGFNTKEYKVERIFADNEDVKVPITLFYKKSLFKKDGSNPLYLMGYGAYGISMPVNFSNMAVTLANRGFI
YAVVHIRGGDDLGHDWYESAKFLTKKRTFEDFIACSRALIKEKYTSNNNIVIMGCSAGGMLIGYVLNEKPEIYRAAVAHV
PFVDVLSTMLDERLPLTLLEYNEWGNPKEKEYFEYIKSYSPYDNVKVQDYPAIFITCGISDPRVGYWEPAKWVAKLRDLK
TDNNPLLLKTNMDTGHKGSVGRFDYLKEITDELVFIFKIFDVKV
>Mature_684_residues
MKPPIANKQNYSFKAHGQTINDYYQWLRDPKWPNVADSKILDYLKAENKYTENFFSDLQKDKEKIFEELRGRVKLDDESV
YIKKKDYYYYHRVVWNKNYPIYCRKHNSMEAEEEVILDVNLLASNSGFTDVAKIAMSPDQTLISYSVDFTGNEQYNIKIY
NLKEQKYLPDEVQDVAPTVIWHEQLNGFFYITINENQRWDKIMFHRLGEDITQDKLIFEVKNPLHFISCKKSASHEYIFI
NSGDHNENEIYVISMQDDSFTPKLVRAAENKIFYDIEHNGDYFYIKTNYKAKNFHAVKLPINNFENTSWDDIYIKEEQDK
YLKSFDVTNNYLILNYRDQGLPLIKIKQFNNLQEKIIHFHDESFQANSFSTNFEEDDIRVDYSSLAIPNTTYSYDFDNNA
LVILKTQEIPSGFNTKEYKVERIFADNEDVKVPITLFYKKSLFKKDGSNPLYLMGYGAYGISMPVNFSNMAVTLANRGFI
YAVVHIRGGDDLGHDWYESAKFLTKKRTFEDFIACSRALIKEKYTSNNNIVIMGCSAGGMLIGYVLNEKPEIYRAAVAHV
PFVDVLSTMLDERLPLTLLEYNEWGNPKEKEYFEYIKSYSPYDNVKVQDYPAIFITCGISDPRVGYWEPAKWVAKLRDLK
TDNNPLLLKTNMDTGHKGSVGRFDYLKEITDELVFIFKIFDVKV

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=705, Percent_Identity=25.6737588652482, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI284172438, Length=542, Percent_Identity=27.859778597786, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI284172431, Length=542, Percent_Identity=27.859778597786, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI284172420, Length=542, Percent_Identity=27.4907749077491, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI284172413, Length=542, Percent_Identity=27.4907749077491, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI70778815, Length=542, Percent_Identity=27.4907749077491, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI108860686, Length=273, Percent_Identity=36.6300366300366, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI108860692, Length=211, Percent_Identity=39.3364928909953, Blast_Score=138, Evalue=2e-32,
Organism=Escherichia coli, GI1788150, Length=687, Percent_Identity=35.6622998544396, Blast_Score=446, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24583414, Length=726, Percent_Identity=27.1349862258953, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI221510989, Length=706, Percent_Identity=25.4957507082153, Blast_Score=206, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 80217; Mature: 80217

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPPIANKQNYSFKAHGQTINDYYQWLRDPKWPNVADSKILDYLKAENKYTENFFSDLQK
CCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
DKEKIFEELRGRVKLDDESVYIKKKDYYYYHRVVWNKNYPIYCRKHNSMEAEEEVILDVN
HHHHHHHHHCCCEEECCCEEEEEECCEEEEEEEEECCCCCEEEEECCCCCCCCEEEEEEE
LLASNSGFTDVAKIAMSPDQTLISYSVDFTGNEQYNIKIYNLKEQKYLPDEVQDVAPTVI
EEECCCCCCHHHHHHCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCCCHHHHHHCCEEE
WHEQLNGFFYITINENQRWDKIMFHRLGEDITQDKLIFEVKNPLHFISCKKSASHEYIFI
EEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCCCCCEEEE
NSGDHNENEIYVISMQDDSFTPKLVRAAENKIFYDIEHNGDYFYIKTNYKAKNFHAVKLP
ECCCCCCCEEEEEEECCCCCCHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCEEEEEEE
INNFENTSWDDIYIKEEQDKYLKSFDVTNNYLILNYRDQGLPLIKIKQFNNLQEKIIHFH
CCCCCCCCCCEEEEECCHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHEEC
DESFQANSFSTNFEEDDIRVDYSSLAIPNTTYSYDFDNNALVILKTQEIPSGFNTKEYKV
CCCCCCCCCCCCCCCCCEEEEHHHEECCCCEEEEECCCCEEEEEEECCCCCCCCCCCEEE
ERIFADNEDVKVPITLFYKKSLFKKDGSNPLYLMGYGAYGISMPVNFSNMAVTLANRGFI
EEEEECCCCCEEEEEEEEEHHHHHCCCCCCEEEEEECCEEEEECCCCCCEEEEEECCCEE
YAVVHIRGGDDLGHDWYESAKFLTKKRTFEDFIACSRALIKEKYTSNNNIVIMGCSAGGM
EEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCE
LIGYVLNEKPEIYRAAVAHVPFVDVLSTMLDERLPLTLLEYNEWGNPKEKEYFEYIKSYS
EEEEEECCCCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCC
PYDNVKVQDYPAIFITCGISDPRVGYWEPAKWVAKLRDLKTDNNPLLLKTNMDTGHKGSV
CCCCCEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
GRFDYLKEITDELVFIFKIFDVKV
CHHHHHHHHHHHHEEEEEEEEECC
>Mature Secondary Structure
MKPPIANKQNYSFKAHGQTINDYYQWLRDPKWPNVADSKILDYLKAENKYTENFFSDLQK
CCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
DKEKIFEELRGRVKLDDESVYIKKKDYYYYHRVVWNKNYPIYCRKHNSMEAEEEVILDVN
HHHHHHHHHCCCEEECCCEEEEEECCEEEEEEEEECCCCCEEEEECCCCCCCCEEEEEEE
LLASNSGFTDVAKIAMSPDQTLISYSVDFTGNEQYNIKIYNLKEQKYLPDEVQDVAPTVI
EEECCCCCCHHHHHHCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCCCHHHHHHCCEEE
WHEQLNGFFYITINENQRWDKIMFHRLGEDITQDKLIFEVKNPLHFISCKKSASHEYIFI
EEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCCCCCEEEE
NSGDHNENEIYVISMQDDSFTPKLVRAAENKIFYDIEHNGDYFYIKTNYKAKNFHAVKLP
ECCCCCCCEEEEEEECCCCCCHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCEEEEEEE
INNFENTSWDDIYIKEEQDKYLKSFDVTNNYLILNYRDQGLPLIKIKQFNNLQEKIIHFH
CCCCCCCCCCEEEEECCHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHEEC
DESFQANSFSTNFEEDDIRVDYSSLAIPNTTYSYDFDNNALVILKTQEIPSGFNTKEYKV
CCCCCCCCCCCCCCCCCEEEEHHHEECCCCEEEEECCCCEEEEEEECCCCCCCCCCCEEE
ERIFADNEDVKVPITLFYKKSLFKKDGSNPLYLMGYGAYGISMPVNFSNMAVTLANRGFI
EEEEECCCCCEEEEEEEEEHHHHHCCCCCCEEEEEECCEEEEECCCCCCEEEEEECCCEE
YAVVHIRGGDDLGHDWYESAKFLTKKRTFEDFIACSRALIKEKYTSNNNIVIMGCSAGGM
EEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCE
LIGYVLNEKPEIYRAAVAHVPFVDVLSTMLDERLPLTLLEYNEWGNPKEKEYFEYIKSYS
EEEEEECCCCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCC
PYDNVKVQDYPAIFITCGISDPRVGYWEPAKWVAKLRDLKTDNNPLLLKTNMDTGHKGSV
CCCCCEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
GRFDYLKEITDELVFIFKIFDVKV
CHHHHHHHHHHHHEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1769955; 9097040; 9278503 [H]