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The map label for this gene is lpxC [H]

Identifier: 157825469

GI number: 157825469

Start: 344266

End: 345132

Strand: Reverse

Name: lpxC [H]

Synonym: A1C_01850

Alternate gene names: 157825469

Gene position: 345132-344266 (Counterclockwise)

Preceding gene: 157825470

Following gene: 157825467

Centisome position: 28.04

GC content: 32.64

Gene sequence:

>867_bases
ATGCAGCAAAGTACATTATTAAAACCGGTTAGTTGTTACGGGATTGGGGTTCACTCGGGAAAACGCACACAGTTAACTAT
GGAACCCGCTAAAGAAAATACCGGAATTATATTCATTAGCACCGATATATCTTCTGAAAAGAATTATATTGAAGCTAGCT
ATTTCAATGTGTCCGATACGTTGTTATCTACCACTATAAGTAATGAGCATAAAGTGCAAATTTCAACAATTGAACATTTA
ATGGCAGCACTTTGGGGATGCAGTATTGATAATGCAATTATTAAAGTTGACGGTCCTGAAGTACCAATTATGGACGGCAG
TAGTAAACCTTTTGTGTTTATGATTGAATGTGCAGGAAAAAAATTACAAAATGCTCCTAAAAAATATCTAAAAATTTTAA
AAGATATAAAAGTAGTTCATAAAGATTGTGAATTATATTGTACTCCTTCCGATCACATGACTGTAGATTTAACTATTGAT
TTTAGCAGTAAAGCTATAGGTAGACAAAATCTAAGTTTTAGAGATCAAGAATCTTTTACTAAAAATATTGCGGATGCTAG
AACTTTTGGATTTATAAGAGATGTTGATTATTTAAAAAGCAAAGGACTTGCCCAAGGTGCCTCATTTGAGAATGCTATAG
GAATAGATGAGCAGGATAAAATCTTAAACCCAAACGGCTTACGTTATGAAGATGAATTTGTTCGCCATAAATTATTAGAT
TTATTCGGTGATTTATATACCAGCGGCACTAGCGTTGTAAGTTCAATTAAAGGTTACAAAACAAGCCACGCTCTTAATAA
TGAATTATTGCATAGAATATTTAGCGATACTACCTCTTACAAATTTGTAACTAGCAACGAGTTATAA

Upstream 100 bases:

>100_bases
ACTGCTTGCAATGACGATTATGTAATATTTTGTAACATAATATAACTTGTATAATTTGGCATTAAAGATTAACATCTAGG
CATATTTTTTATAGCCTCGC

Downstream 100 bases:

>100_bases
TAATCATTTCATATTGTTAAATTTCGCTTTCTTTTTTGCATCCTTTTTAAATTTTCACGTTTTGTCCTTTTTATTTCAGC
ATTATTAACTTTATCTTTAT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MQQSTLLKPVSCYGIGVHSGKRTQLTMEPAKENTGIIFISTDISSEKNYIEASYFNVSDTLLSTTISNEHKVQISTIEHL
MAALWGCSIDNAIIKVDGPEVPIMDGSSKPFVFMIECAGKKLQNAPKKYLKILKDIKVVHKDCELYCTPSDHMTVDLTID
FSSKAIGRQNLSFRDQESFTKNIADARTFGFIRDVDYLKSKGLAQGASFENAIGIDEQDKILNPNGLRYEDEFVRHKLLD
LFGDLYTSGTSVVSSIKGYKTSHALNNELLHRIFSDTTSYKFVTSNEL

Sequences:

>Translated_288_residues
MQQSTLLKPVSCYGIGVHSGKRTQLTMEPAKENTGIIFISTDISSEKNYIEASYFNVSDTLLSTTISNEHKVQISTIEHL
MAALWGCSIDNAIIKVDGPEVPIMDGSSKPFVFMIECAGKKLQNAPKKYLKILKDIKVVHKDCELYCTPSDHMTVDLTID
FSSKAIGRQNLSFRDQESFTKNIADARTFGFIRDVDYLKSKGLAQGASFENAIGIDEQDKILNPNGLRYEDEFVRHKLLD
LFGDLYTSGTSVVSSIKGYKTSHALNNELLHRIFSDTTSYKFVTSNEL
>Mature_288_residues
MQQSTLLKPVSCYGIGVHSGKRTQLTMEPAKENTGIIFISTDISSEKNYIEASYFNVSDTLLSTTISNEHKVQISTIEHL
MAALWGCSIDNAIIKVDGPEVPIMDGSSKPFVFMIECAGKKLQNAPKKYLKILKDIKVVHKDCELYCTPSDHMTVDLTID
FSSKAIGRQNLSFRDQESFTKNIADARTFGFIRDVDYLKSKGLAQGASFENAIGIDEQDKILNPNGLRYEDEFVRHKLLD
LFGDLYTSGTSVVSSIKGYKTSHALNNELLHRIFSDTTSYKFVTSNEL

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=287, Percent_Identity=42.8571428571429, Blast_Score=253, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32175; Mature: 32175

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00014 ER_TARGET

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQSTLLKPVSCYGIGVHSGKRTQLTMEPAKENTGIIFISTDISSEKNYIEASYFNVSDT
CCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEEECCHHH
LLSTTISNEHKVQISTIEHLMAALWGCSIDNAIIKVDGPEVPIMDGSSKPFVFMIECAGK
HHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCEEEEEEECCC
KLQNAPKKYLKILKDIKVVHKDCELYCTPSDHMTVDLTIDFSSKAIGRQNLSFRDQESFT
HHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHH
KNIADARTFGFIRDVDYLKSKGLAQGASFENAIGIDEQDKILNPNGLRYEDEFVRHKLLD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LFGDLYTSGTSVVSSIKGYKTSHALNNELLHRIFSDTTSYKFVTSNEL
HHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCC
>Mature Secondary Structure
MQQSTLLKPVSCYGIGVHSGKRTQLTMEPAKENTGIIFISTDISSEKNYIEASYFNVSDT
CCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEEECCHHH
LLSTTISNEHKVQISTIEHLMAALWGCSIDNAIIKVDGPEVPIMDGSSKPFVFMIECAGK
HHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCEEEEEEECCC
KLQNAPKKYLKILKDIKVVHKDCELYCTPSDHMTVDLTIDFSSKAIGRQNLSFRDQESFT
HHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHH
KNIADARTFGFIRDVDYLKSKGLAQGASFENAIGIDEQDKILNPNGLRYEDEFVRHKLLD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LFGDLYTSGTSVVSSIKGYKTSHALNNELLHRIFSDTTSYKFVTSNEL
HHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA