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The map label for this gene is degP [H]

Identifier: 157825302

GI number: 157825302

Start: 171236

End: 172774

Strand: Direct

Name: degP [H]

Synonym: A1C_00920

Alternate gene names: 157825302

Gene position: 171236-172774 (Clockwise)

Preceding gene: 157825301

Following gene: 157825303

Centisome position: 13.91

GC content: 32.03

Gene sequence:

>1539_bases
ATGAATCTGAAAATAGTTCTTGTTATAATAATTTTAATATCAAGTAACGTTATTCTAGCAAAAGAAAATAATAAGTCTTT
AAAATTAGCGGATCAAGCAGAGAATGAATTTACGGCAATAAATTCTGCACCTTTAAAAGTAAGTGAAGCTGCTCGTTATA
GTTTTGCTGATATAGTTGAGCCGTTAATTCCCGCAGTTGTTAATATTTCAACAATAGAATATGTTAATAGTAAGTCGGAA
AATGCTGAGAAAGATCCGCTGCAAGAAACAAATCCTTTAGACTTTATTAATTATTTTTTAGAAAAGTTAAATATTCCATT
GAATTTGGAAGAAATCGATCAAACTCCAAAAATTGTTCCGCTTGGTTCAGGATTTATTATTGAGCCTAACGGTTTAATAG
TCACTAACTATCATGTCATTGCAAATGTTAATAAAATTAATATAAAGCTTGCAGATAATACTGAATTACCTGCTAAGCTA
ATAGGTAGCGATACTAAAACCGATTTAGCTCTCTTAAAAATAGATAGTGATGAGCCTTTACCTTTTGTTGAGTTTGGAGA
TTCAAATGATGCAAGAGTAGGAGATTGGGTTATTGCAATCGGTAATCCGTTCGGTAATCTAGGTGGTACGGTGACAAGCG
GTATTATATCCTCTAAAGGGCGGGATATTGATATAGATACAGACAATATAGTCGATAATTTTATTCAAACGGATGCTGCA
ATTAATAACGGTAATTCCGGCGGTCCTATGTTTAATTTGGATCAGAAAGTAATCGGAGTAAATACGGCGATTTTTTCACC
ACTCGGTACTAATATAGGTATAGGTTTTGCTATTCCATCAAATACTGCAAAGCCTATAATCGAACGTCTTAAGAAAGATG
GAAAAGTAAGTAGAGGACGCCTTGGAGTAACAATACAAGATTTAACCGAGGAAATTTCTGAAGGGCTAGGACTTAAAGAC
ACTAACGGTGTGTTAGTAGCTAAAGTACAAGAAGACGGTCCAGGTGATCAAGCGGGTATTAAAACGGGTGATATAATAAT
AGAGTTTGGAGATATACCGGTTAAAAACACTAAAAAATTACGTGTAATTATTGCAGATACTCCTATTAATCAAGAAGTAA
AATTAAAAATACTACGTGATAAAAAAGTGCTTGAATTGCCTATTAAGATTACTTCAGATAATGAAGAAGTTACCAATGAT
TCTACAGAAGAGACGAATAAAGAAGAAATAACAAACAAAGAAGAAAATAGTTTATCTATTACTAAAAATAATATTACTTT
TAGTAATATTACTGAAGCACTAAGAAAAAAATATACTATTCCTCAAGATAAAACGGGAATAGTTATAACAAATATTGATG
CAGAAGAAAGTAGTTTCAAAATTGGTGATCTGATAACCAATATTAATCAGGAAAGCGTAGACGATATAAGTAAGCTAGAA
GAATTATATGAAAATGCTAAAAAATCAAATAAGCAAAATATTTTGCTCTTGATTGAAAGGTGTGATACAAGTGTGTTCAT
GCCGTTATCGGTGGTGTAG

Upstream 100 bases:

>100_bases
CTGTTAGTATATAAAAATTCTTTAAAGAAAGAAGATACTAATTTTGTGATTTCACCGGATGCTGAAGTTTTAAAATACCT
TAATTTAACTAAGTAGTGTG

Downstream 100 bases:

>100_bases
AGTCCTGTCGTCATTGCTAGGAGCCGTAGGCGGACGCGGGGGGCAATGGCGTTAACAATAATAATACATAAATAATTTAT
GAGTGAAAAAATAGCAATTT

Product: periplasmic serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MNLKIVLVIIILISSNVILAKENNKSLKLADQAENEFTAINSAPLKVSEAARYSFADIVEPLIPAVVNISTIEYVNSKSE
NAEKDPLQETNPLDFINYFLEKLNIPLNLEEIDQTPKIVPLGSGFIIEPNGLIVTNYHVIANVNKINIKLADNTELPAKL
IGSDTKTDLALLKIDSDEPLPFVEFGDSNDARVGDWVIAIGNPFGNLGGTVTSGIISSKGRDIDIDTDNIVDNFIQTDAA
INNGNSGGPMFNLDQKVIGVNTAIFSPLGTNIGIGFAIPSNTAKPIIERLKKDGKVSRGRLGVTIQDLTEEISEGLGLKD
TNGVLVAKVQEDGPGDQAGIKTGDIIIEFGDIPVKNTKKLRVIIADTPINQEVKLKILRDKKVLELPIKITSDNEEVTND
STEETNKEEITNKEENSLSITKNNITFSNITEALRKKYTIPQDKTGIVITNIDAEESSFKIGDLITNINQESVDDISKLE
ELYENAKKSNKQNILLLIERCDTSVFMPLSVV

Sequences:

>Translated_512_residues
MNLKIVLVIIILISSNVILAKENNKSLKLADQAENEFTAINSAPLKVSEAARYSFADIVEPLIPAVVNISTIEYVNSKSE
NAEKDPLQETNPLDFINYFLEKLNIPLNLEEIDQTPKIVPLGSGFIIEPNGLIVTNYHVIANVNKINIKLADNTELPAKL
IGSDTKTDLALLKIDSDEPLPFVEFGDSNDARVGDWVIAIGNPFGNLGGTVTSGIISSKGRDIDIDTDNIVDNFIQTDAA
INNGNSGGPMFNLDQKVIGVNTAIFSPLGTNIGIGFAIPSNTAKPIIERLKKDGKVSRGRLGVTIQDLTEEISEGLGLKD
TNGVLVAKVQEDGPGDQAGIKTGDIIIEFGDIPVKNTKKLRVIIADTPINQEVKLKILRDKKVLELPIKITSDNEEVTND
STEETNKEEITNKEENSLSITKNNITFSNITEALRKKYTIPQDKTGIVITNIDAEESSFKIGDLITNINQESVDDISKLE
ELYENAKKSNKQNILLLIERCDTSVFMPLSVV
>Mature_512_residues
MNLKIVLVIIILISSNVILAKENNKSLKLADQAENEFTAINSAPLKVSEAARYSFADIVEPLIPAVVNISTIEYVNSKSE
NAEKDPLQETNPLDFINYFLEKLNIPLNLEEIDQTPKIVPLGSGFIIEPNGLIVTNYHVIANVNKINIKLADNTELPAKL
IGSDTKTDLALLKIDSDEPLPFVEFGDSNDARVGDWVIAIGNPFGNLGGTVTSGIISSKGRDIDIDTDNIVDNFIQTDAA
INNGNSGGPMFNLDQKVIGVNTAIFSPLGTNIGIGFAIPSNTAKPIIERLKKDGKVSRGRLGVTIQDLTEEISEGLGLKD
TNGVLVAKVQEDGPGDQAGIKTGDIIIEFGDIPVKNTKKLRVIIADTPINQEVKLKILRDKKVLELPIKITSDNEEVTND
STEETNKEEITNKEENSLSITKNNITFSNITEALRKKYTIPQDKTGIVITNIDAEESSFKIGDLITNINQESVDDISKLE
ELYENAKKSNKQNILLLIERCDTSVFMPLSVV

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI7019477, Length=298, Percent_Identity=35.9060402684564, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI4506141, Length=313, Percent_Identity=34.8242811501597, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI22129776, Length=381, Percent_Identity=29.9212598425197, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI24308541, Length=257, Percent_Identity=35.7976653696498, Blast_Score=142, Evalue=9e-34,
Organism=Escherichia coli, GI1786356, Length=397, Percent_Identity=35.7682619647355, Blast_Score=232, Evalue=5e-62,
Organism=Escherichia coli, GI1789629, Length=357, Percent_Identity=39.2156862745098, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1789630, Length=273, Percent_Identity=38.8278388278388, Blast_Score=169, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24646839, Length=286, Percent_Identity=36.3636363636364, Blast_Score=148, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 55889; Mature: 55889

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKIVLVIIILISSNVILAKENNKSLKLADQAENEFTAINSAPLKVSEAARYSFADIVE
CCEEEEEEEEHHHCCCEEEEECCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHH
PLIPAVVNISTIEYVNSKSENAEKDPLQETNPLDFINYFLEKLNIPLNLEEIDQTPKIVP
HHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCEEE
LGSGFIIEPNGLIVTNYHVIANVNKINIKLADNTELPAKLIGSDTKTDLALLKIDSDEPL
CCCCEEECCCCEEEEEEEEEEEEEEEEEEECCCCCCCHHHHCCCCCCCEEEEEECCCCCC
PFVEFGDSNDARVGDWVIAIGNPFGNLGGTVTSGIISSKGRDIDIDTDNIVDNFIQTDAA
CEEEECCCCCCEECEEEEEECCCCCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHCCC
INNGNSGGPMFNLDQKVIGVNTAIFSPLGTNIGIGFAIPSNTAKPIIERLKKDGKVSRGR
CCCCCCCCCEEECCCEEEEECHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCE
LGVTIQDLTEEISEGLGLKDTNGVLVAKVQEDGPGDQAGIKTGDIIIEFGDIPVKNTKKL
ECEEHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCEECCEEEEECCCCCCCCCEE
RVIIADTPINQEVKLKILRDKKVLELPIKITSDNEEVTNDSTEETNKEEITNKEENSLSI
EEEEECCCCCCCEEEEEEECCEEEEEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCEEE
TKNNITFSNITEALRKKYTIPQDKTGIVITNIDAEESSFKIGDLITNINQESVDDISKLE
EECCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEHHHHHHCCCHHHHHHHHHHH
ELYENAKKSNKQNILLLIERCDTSVFMPLSVV
HHHHHHHHCCCCCEEEEEEECCCEEEEEEEEC
>Mature Secondary Structure
MNLKIVLVIIILISSNVILAKENNKSLKLADQAENEFTAINSAPLKVSEAARYSFADIVE
CCEEEEEEEEHHHCCCEEEEECCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHH
PLIPAVVNISTIEYVNSKSENAEKDPLQETNPLDFINYFLEKLNIPLNLEEIDQTPKIVP
HHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCEEE
LGSGFIIEPNGLIVTNYHVIANVNKINIKLADNTELPAKLIGSDTKTDLALLKIDSDEPL
CCCCEEECCCCEEEEEEEEEEEEEEEEEEECCCCCCCHHHHCCCCCCCEEEEEECCCCCC
PFVEFGDSNDARVGDWVIAIGNPFGNLGGTVTSGIISSKGRDIDIDTDNIVDNFIQTDAA
CEEEECCCCCCEECEEEEEECCCCCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHCCC
INNGNSGGPMFNLDQKVIGVNTAIFSPLGTNIGIGFAIPSNTAKPIIERLKKDGKVSRGR
CCCCCCCCCEEECCCEEEEECHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCE
LGVTIQDLTEEISEGLGLKDTNGVLVAKVQEDGPGDQAGIKTGDIIIEFGDIPVKNTKKL
ECEEHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCEECCEEEEECCCCCCCCCEE
RVIIADTPINQEVKLKILRDKKVLELPIKITSDNEEVTNDSTEETNKEEITNKEENSLSI
EEEEECCCCCCCEEEEEEECCEEEEEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCEEE
TKNNITFSNITEALRKKYTIPQDKTGIVITNIDAEESSFKIGDLITNINQESVDDISKLE
EECCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEHHHHHHCCCHHHHHHHHHHH
ELYENAKKSNKQNILLLIERCDTSVFMPLSVV
HHHHHHHHCCCCCEEEEEEECCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]