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The map label for this gene is hflC [H]

Identifier: 157825301

GI number: 157825301

Start: 170371

End: 171231

Strand: Direct

Name: hflC [H]

Synonym: A1C_00915

Alternate gene names: 157825301

Gene position: 170371-171231 (Clockwise)

Preceding gene: 157825300

Following gene: 157825302

Centisome position: 13.84

GC content: 32.87

Gene sequence:

>861_bases
ATGCAACAAAAGATTTATTATATAATTTTTACAATTGTTTTTGGGATGATACTGATTTTTAGCTCCTTATTTTCAGTTGA
TCAACGCCAGTCTGCTGTGGTATTCCAGTTTGGTGAGGCAGTGAGAACTATAGAAAATCCAGGACTAAATATTAAAATCC
CATTTATTCAAAATGTTGAATTTTTTGATAAGCGTCTTTTAGATGTTGAGGTTGAGGCAAAAGAATTAACGGCTGCTGAC
GGTAAACGAGTTATTGTTGATGCTTATGCCAAATTCCAAATTAATAATCCTGTAATGTTTTATAAAACGGTACATGATTA
TCAAGGTGTGAAAATCAGGTTAACTCGTAATCTTGAATCGTCGATGCGTAAAGTGATAGGTAAAATTTCGTTAAGTAGTC
TTTTAAGTCGGGAACGTAGTAATGTAATGCTAAATATCTTAAATCAAGTAGACGGAGAAGCTAAAAGCTTTGGAATTGAT
GTTGTAGATGTTAGAATTTTAAGAGCAGACTTACCGAAAGAAAACAGTGCAGCTATTTATCGTCGTATGCAAACGGCACG
TGAAAAAGAAGCGACCCAAATTAGAGCAGAAGGACAAGAAGAGAGCGTACGTATTCGTTCAAAAGCAGATAAAGAAAGTA
AAATAATACTTGCCAAAGCTTATAGAGATGCACAAATTATTAAAGGTGACGGCGATGAAAAAGCAGCAAAAATATATAAT
TCCGCTTATTCCGTCGATCCAGAATTTTACAAATTTTATAGATCACTGTTAGTATATAAAAATTCTTTAAAGAAAGAAGA
TACTAATTTTGTGATTTCACCGGATGCTGAAGTTTTAAAATACCTTAATTTAACTAAGTAG

Upstream 100 bases:

>100_bases
GGCAATCTCATGAAATAATAAAATTCCTGAGATTGCCGCGTCGAGGCTTTACCCCTCCTCGCGGTGACGGAGCTAATAAA
AACACAACAAGGAATATTAA

Downstream 100 bases:

>100_bases
TGTGATGAATCTGAAAATAGTTCTTGTTATAATAATTTTAATATCAAGTAACGTTATTCTAGCAAAAGAAAATAATAAGT
CTTTAAAATTAGCGGATCAA

Product: membrane protease subunit stomatin/prohibitin-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MQQKIYYIIFTIVFGMILIFSSLFSVDQRQSAVVFQFGEAVRTIENPGLNIKIPFIQNVEFFDKRLLDVEVEAKELTAAD
GKRVIVDAYAKFQINNPVMFYKTVHDYQGVKIRLTRNLESSMRKVIGKISLSSLLSRERSNVMLNILNQVDGEAKSFGID
VVDVRILRADLPKENSAAIYRRMQTAREKEATQIRAEGQEESVRIRSKADKESKIILAKAYRDAQIIKGDGDEKAAKIYN
SAYSVDPEFYKFYRSLLVYKNSLKKEDTNFVISPDAEVLKYLNLTK

Sequences:

>Translated_286_residues
MQQKIYYIIFTIVFGMILIFSSLFSVDQRQSAVVFQFGEAVRTIENPGLNIKIPFIQNVEFFDKRLLDVEVEAKELTAAD
GKRVIVDAYAKFQINNPVMFYKTVHDYQGVKIRLTRNLESSMRKVIGKISLSSLLSRERSNVMLNILNQVDGEAKSFGID
VVDVRILRADLPKENSAAIYRRMQTAREKEATQIRAEGQEESVRIRSKADKESKIILAKAYRDAQIIKGDGDEKAAKIYN
SAYSVDPEFYKFYRSLLVYKNSLKKEDTNFVISPDAEVLKYLNLTK
>Mature_286_residues
MQQKIYYIIFTIVFGMILIFSSLFSVDQRQSAVVFQFGEAVRTIENPGLNIKIPFIQNVEFFDKRLLDVEVEAKELTAAD
GKRVIVDAYAKFQINNPVMFYKTVHDYQGVKIRLTRNLESSMRKVIGKISLSSLLSRERSNVMLNILNQVDGEAKSFGID
VVDVRILRADLPKENSAAIYRRMQTAREKEATQIRAEGQEESVRIRSKADKESKIILAKAYRDAQIIKGDGDEKAAKIYN
SAYSVDPEFYKFYRSLLVYKNSLKKEDTNFVISPDAEVLKYLNLTK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI7305503, Length=209, Percent_Identity=25.3588516746411, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1790617, Length=310, Percent_Identity=31.6129032258064, Blast_Score=157, Evalue=5e-40,
Organism=Escherichia coli, GI1786697, Length=237, Percent_Identity=24.4725738396624, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17569497, Length=196, Percent_Identity=26.530612244898, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193209764, Length=200, Percent_Identity=28, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32564147, Length=214, Percent_Identity=24.7663551401869, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45550506, Length=208, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 32810; Mature: 32810

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQKIYYIIFTIVFGMILIFSSLFSVDQRQSAVVFQFGEAVRTIENPGLNIKIPFIQNVE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHCCCCCEEEECCCCCHH
FFDKRLLDVEVEAKELTAADGKRVIVDAYAKFQINNPVMFYKTVHDYQGVKIRLTRNLES
HHHHHHHCEEECHHHHHCCCCCEEEEEEEEEEEECCCEEEEEEECCCCCEEEEEECCHHH
SMRKVIGKISLSSLLSRERSNVMLNILNQVDGEAKSFGIDVVDVRILRADLPKENSAAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEEECCCCCCCHHHHH
RRMQTAREKEATQIRAEGQEESVRIRSKADKESKIILAKAYRDAQIIKGDGDEKAAKIYN
HHHHHHHHHHHHHHHCCCCCHHEEEHHCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHH
SAYSVDPEFYKFYRSLLVYKNSLKKEDTNFVISPDAEVLKYLNLTK
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCC
>Mature Secondary Structure
MQQKIYYIIFTIVFGMILIFSSLFSVDQRQSAVVFQFGEAVRTIENPGLNIKIPFIQNVE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHCCCCCEEEECCCCCHH
FFDKRLLDVEVEAKELTAADGKRVIVDAYAKFQINNPVMFYKTVHDYQGVKIRLTRNLES
HHHHHHHCEEECHHHHHCCCCCEEEEEEEEEEEECCCEEEEEEECCCCCEEEEEECCHHH
SMRKVIGKISLSSLLSRERSNVMLNILNQVDGEAKSFGIDVVDVRILRADLPKENSAAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEEECCCCCCCHHHHH
RRMQTAREKEATQIRAEGQEESVRIRSKADKESKIILAKAYRDAQIIKGDGDEKAAKIYN
HHHHHHHHHHHHHHHCCCCCHHEEEHHCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHH
SAYSVDPEFYKFYRSLLVYKNSLKKEDTNFVISPDAEVLKYLNLTK
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]