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The map label for this gene is fadA [H]

Identifier: 157373089

GI number: 157373089

Start: 5378488

End: 5379666

Strand: Reverse

Name: fadA [H]

Synonym: Spro_4857

Alternate gene names: 157373089

Gene position: 5379666-5378488 (Counterclockwise)

Preceding gene: 157373090

Following gene: 157373082

Centisome position: 98.73

GC content: 53.86

Gene sequence:

>1179_bases
ATGCGTGATGCCGTTATTGTTTCTACAGCCCGAACTCCGATTGGCAAAGCCTATCGTGGCGCTTTCAATGCCACCCCATC
TGCAACACTGGCTGGGCATGCAATTAAGCATGCTGTCGAGCGAGCAGGAATTTTAGGTAGTGAAGTGGATGATGTGTTAC
TCGGTTCAGCCTTGCAGCAAGGTGTGCAAGGTTTGAACATTGGCCGCCTGGCTGCATTGCGGGCCGGGTTGCCCACGTCA
GTTTCAGGTATGTCGTTGGATCGCCAGTGCGCCTCGGGTCTTATGGCTGTTGCCACGGCTGCCAAACAAATCATTGTCGA
TGGTATGAGCATTGCCGTTGCGGGAGGTGTGGAATCCATCTCGATGGTGCAGACTGACCGGATACGCATTGAGCCGGATA
TGGAGCTTTTCGCGCTGTATCCAGCTGCATATATGCAAATGGTGGATACGGCTGACATAGTGGCAAAGCGCTATGAGATC
AGCCGGGAAGCCTGTGACGAATACTCGCTGCGCTCCCAGCAACGAACGGCAGCAGCACAATTAGAAGGGCTGTTCGACAA
GGAAATTGTTCCTATGCGTTCTTTGATGGCCTACAACGATCAGGAAACCGGCGTATTGGCTTATAAAGAGGTATTGCTGG
AGCGTGACGAAGGCAATCGCCCACAAAGTACCCTTGAGGATTTGCAGGCTCTCTATTCCGTCAAAGGACCTGGCAAAAAT
GTTACCGCCGGCAACGCCAGTCAACTCTCCGATGGTGCCTCAGCGCTAGTGCTGATGGAAGCCAAAGAGGCCGAACGAAG
GGGCCTGCAGCCGTTAGGTCGCTATGTAGGTATGGCCGTAGCGGGTGTTGATCCGGACGAGATGGGAATTGGCCCAGTGG
CGGCGGTGCCTAAATTGCTGCATAGCAATGGTCTAAAGATTGATGATATCGGATTATGGGAGCTCAATGAGGCATTTGCA
GTACAAGTACTCTATTGCCGAGACCGACTGGGCATTCCGGACGACAGGCTGAACGTGAACGGCGGCGCAATTGCAATCGG
GCACCCCTACGGCATGTCCGGCGCCCGTATGACAGGCCATGCGCTGATAGAAGGAAAGCGTAGAGGCGAACGCTACGCCG
TAGTGACGATGTGTATCGGTGGGGGAATGGGGGCAGCGGGTTTATTCGAAATTTATTGA

Upstream 100 bases:

>100_bases
CGAATCAGAGCAAGTTCCTGAGTCTGCCACTGCGCAGGTTCATCAAGAACTCATCGCTGCTTTCCGTTCAGAATCCGAAA
ATAACCAGTGAGAATCTACT

Downstream 100 bases:

>100_bases
GAGCAGCGCTTCAGTTGTTTAACTCTCAAATTTCCGTTTCGCCATCCTGCTGCAAATTCCGAAGGTAATTGATAATTCAA
CGAAGAATGGGGCCGACATT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MRDAVIVSTARTPIGKAYRGAFNATPSATLAGHAIKHAVERAGILGSEVDDVLLGSALQQGVQGLNIGRLAALRAGLPTS
VSGMSLDRQCASGLMAVATAAKQIIVDGMSIAVAGGVESISMVQTDRIRIEPDMELFALYPAAYMQMVDTADIVAKRYEI
SREACDEYSLRSQQRTAAAQLEGLFDKEIVPMRSLMAYNDQETGVLAYKEVLLERDEGNRPQSTLEDLQALYSVKGPGKN
VTAGNASQLSDGASALVLMEAKEAERRGLQPLGRYVGMAVAGVDPDEMGIGPVAAVPKLLHSNGLKIDDIGLWELNEAFA
VQVLYCRDRLGIPDDRLNVNGGAIAIGHPYGMSGARMTGHALIEGKRRGERYAVVTMCIGGGMGAAGLFEIY

Sequences:

>Translated_392_residues
MRDAVIVSTARTPIGKAYRGAFNATPSATLAGHAIKHAVERAGILGSEVDDVLLGSALQQGVQGLNIGRLAALRAGLPTS
VSGMSLDRQCASGLMAVATAAKQIIVDGMSIAVAGGVESISMVQTDRIRIEPDMELFALYPAAYMQMVDTADIVAKRYEI
SREACDEYSLRSQQRTAAAQLEGLFDKEIVPMRSLMAYNDQETGVLAYKEVLLERDEGNRPQSTLEDLQALYSVKGPGKN
VTAGNASQLSDGASALVLMEAKEAERRGLQPLGRYVGMAVAGVDPDEMGIGPVAAVPKLLHSNGLKIDDIGLWELNEAFA
VQVLYCRDRLGIPDDRLNVNGGAIAIGHPYGMSGARMTGHALIEGKRRGERYAVVTMCIGGGMGAAGLFEIY
>Mature_392_residues
MRDAVIVSTARTPIGKAYRGAFNATPSATLAGHAIKHAVERAGILGSEVDDVLLGSALQQGVQGLNIGRLAALRAGLPTS
VSGMSLDRQCASGLMAVATAAKQIIVDGMSIAVAGGVESISMVQTDRIRIEPDMELFALYPAAYMQMVDTADIVAKRYEI
SREACDEYSLRSQQRTAAAQLEGLFDKEIVPMRSLMAYNDQETGVLAYKEVLLERDEGNRPQSTLEDLQALYSVKGPGKN
VTAGNASQLSDGASALVLMEAKEAERRGLQPLGRYVGMAVAGVDPDEMGIGPVAAVPKLLHSNGLKIDDIGLWELNEAFA
VQVLYCRDRLGIPDDRLNVNGGAIAIGHPYGMSGARMTGHALIEGKRRGERYAVVTMCIGGGMGAAGLFEIY

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=39.8989898989899, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=36.318407960199, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI148539872, Length=403, Percent_Identity=37.9652605459057, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI4557237, Length=403, Percent_Identity=36.2282878411911, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI4504327, Length=443, Percent_Identity=28.4424379232506, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI194353979, Length=88, Percent_Identity=53.4090909090909, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=42.2982885085575, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=40.3465346534653, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=37.6262626262626, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=37.0646766169154, Blast_Score=207, Evalue=8e-55,
Organism=Escherichia coli, GI1788683, Length=418, Percent_Identity=30.1435406698565, Blast_Score=154, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=397, Percent_Identity=36.7758186397985, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17535921, Length=412, Percent_Identity=33.495145631068, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=32.7455919395466, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=443, Percent_Identity=28.4424379232506, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17535917, Length=389, Percent_Identity=29.0488431876607, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322031, Length=403, Percent_Identity=36.2282878411911, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=408, Percent_Identity=30.3921568627451, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=40.0503778337531, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=37.4371859296482, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24640423, Length=404, Percent_Identity=33.9108910891089, Blast_Score=217, Evalue=9e-57,
Organism=Drosophila melanogaster, GI17137578, Length=439, Percent_Identity=29.6127562642369, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41585; Mature: 41585

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAVIVSTARTPIGKAYRGAFNATPSATLAGHAIKHAVERAGILGSEVDDVLLGSALQQ
CCCCEEEEECCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GVQGLNIGRLAALRAGLPTSVSGMSLDRQCASGLMAVATAAKQIIVDGMSIAVAGGVESI
HHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHH
SMVQTDRIRIEPDMELFALYPAAYMQMVDTADIVAKRYEISREACDEYSLRSQQRTAAAQ
HEEEECCEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEGLFDKEIVPMRSLMAYNDQETGVLAYKEVLLERDEGNRPQSTLEDLQALYSVKGPGKN
HHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
VTAGNASQLSDGASALVLMEAKEAERRGLQPLGRYVGMAVAGVDPDEMGIGPVAAVPKLL
CCCCCHHHCCCCCCEEEEEECHHHHHCCCHHHHHHHHEEEECCCHHHCCCCHHHHHHHHH
HSNGLKIDDIGLWELNEAFAVQVLYCRDRLGIPDDRLNVNGGAIAIGHPYGMSGARMTGH
HCCCCEEECCCCEECCHHHEEEEEEECCCCCCCCCCEECCCCEEEECCCCCCCCCCCCCH
ALIEGKRRGERYAVVTMCIGGGMGAAGLFEIY
HEEECCCCCCEEEEEEEEECCCCCCCCEEECC
>Mature Secondary Structure
MRDAVIVSTARTPIGKAYRGAFNATPSATLAGHAIKHAVERAGILGSEVDDVLLGSALQQ
CCCCEEEEECCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GVQGLNIGRLAALRAGLPTSVSGMSLDRQCASGLMAVATAAKQIIVDGMSIAVAGGVESI
HHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHH
SMVQTDRIRIEPDMELFALYPAAYMQMVDTADIVAKRYEISREACDEYSLRSQQRTAAAQ
HEEEECCEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEGLFDKEIVPMRSLMAYNDQETGVLAYKEVLLERDEGNRPQSTLEDLQALYSVKGPGKN
HHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
VTAGNASQLSDGASALVLMEAKEAERRGLQPLGRYVGMAVAGVDPDEMGIGPVAAVPKLL
CCCCCHHHCCCCCCEEEEEECHHHHHCCCHHHHHHHHEEEECCCHHHCCCCHHHHHHHHH
HSNGLKIDDIGLWELNEAFAVQVLYCRDRLGIPDDRLNVNGGAIAIGHPYGMSGARMTGH
HCCCCEEECCCCEECCHHHEEEEEEECCCCCCCCCCEECCCCEEEECCCCCCCCCCCCCH
ALIEGKRRGERYAVVTMCIGGGMGAAGLFEIY
HEEECCCCCCEEEEEEEEECCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]