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The map label for this gene is tdh [H]

Identifier: 157373055

GI number: 157373055

Start: 5342615

End: 5343640

Strand: Reverse

Name: tdh [H]

Synonym: Spro_4823

Alternate gene names: 157373055

Gene position: 5343640-5342615 (Counterclockwise)

Preceding gene: 157373056

Following gene: 157373050

Centisome position: 98.07

GC content: 55.36

Gene sequence:

>1026_bases
ATGAAAGCATTGTCAAAACTGAAAGCGGAAGAAGGGATTTGGATGACCGATGTGCCTCAGCCGGAGCTGGGCCATAACGA
CATCATGATTAAAATCCGTAAAACTGCGATCTGCGGTACCGATGTTCATATTTATAACTGGGATGAATGGTCACAGAAAA
CCATCCCGGTCCCTATGGTGGTCGGCCACGAATATGTGGGTGAAGTGGTCGCCATCGGCCAGGAAGTCAAAGGCTTCACT
GTCGGTGACCGCGTTTCCGGCGAAGGCCATATCACCTGTGGCCATTGCCGTAACTGCCGTGGTGGCCGTACGCACCTGTG
TCGCAACACCACCGGCGTGGGCGTGAACCGTCCAGGCTCATTTGCTGAATATCTGGTGATCCCGGCGTTTAACGCCTTCA
AAATCCCGGACAATATTTCCGATGAGCTGGCGTCTATCTTCGACCCGTTCGGCAATGCGGTTCACACCGCGCTGTCGTTT
GATCTGGTTGGCGAAGACGTGCTGGTTTCCGGTGCCGGGCCGATCGGCATCATGGCGGCGGCGGTGTGCAAGCACGTTGG
CGCCCGCCATGTGGTGATCACCGACGTTAACGAATACCGCCTGGATCTGGCGCGCAAAATGGGCGTGACCCGTGCGGTGA
ACGTCAGCAAAGAAAACCTGAATGACGTGATGGCCGAACTGGGCATGACCGAAGGGTTTGACGTTGGGCTGGAAATGTCC
GGTGCGCCACCGGCGTTCCGTACCTTGCTCAATGCGATGAACCACGGCGGGCGTATTGCCATGCTGGGTATTCCACCGTC
GGATATGTCGATCGACTGGAATCAGGTGATCTTCAAGGGGCTGTTTATCAAAGGGATTTACGGCCGTGAAATGTTTGAGA
CCTGGTACAAGATGGCAGCGCTGATCCAGTCTGGCCTGGATCTGACACCTATCATCACTCACCGTTTCACAATCGACCAG
TTCCAACAAGGCTTTGACGCCATGCGCTCCGGCCAGTCCGGCAAAGTGGTTTTGAGCTGGGATTAG

Upstream 100 bases:

>100_bases
CCAGATGTCCGCCGATCACACCCCGGAGCAAATTGAACGTGCGATTGCGGCGTTCATTCGTATCGGTAAAGATCTTGGCG
TTATTGCATAAGGTAAAACC

Downstream 100 bases:

>100_bases
TTTTTTAAATCCGGGTCGATGTGGATAAAAAGGGCCGGAATTTCCGGCCCTGAATGCGTGCTCAAGTATTAATTGCACGG
GCCATGTATGGTGCTTCAGT

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKALSKLKAEEGIWMTDVPQPELGHNDIMIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVAIGQEVKGFT
VGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGSFAEYLVIPAFNAFKIPDNISDELASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGIMAAAVCKHVGARHVVITDVNEYRLDLARKMGVTRAVNVSKENLNDVMAELGMTEGFDVGLEMS
GAPPAFRTLLNAMNHGGRIAMLGIPPSDMSIDWNQVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLTPIITHRFTIDQ
FQQGFDAMRSGQSGKVVLSWD

Sequences:

>Translated_341_residues
MKALSKLKAEEGIWMTDVPQPELGHNDIMIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVAIGQEVKGFT
VGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGSFAEYLVIPAFNAFKIPDNISDELASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGIMAAAVCKHVGARHVVITDVNEYRLDLARKMGVTRAVNVSKENLNDVMAELGMTEGFDVGLEMS
GAPPAFRTLLNAMNHGGRIAMLGIPPSDMSIDWNQVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLTPIITHRFTIDQ
FQQGFDAMRSGQSGKVVLSWD
>Mature_341_residues
MKALSKLKAEEGIWMTDVPQPELGHNDIMIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVAIGQEVKGFT
VGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGSFAEYLVIPAFNAFKIPDNISDELASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGIMAAAVCKHVGARHVVITDVNEYRLDLARKMGVTRAVNVSKENLNDVMAELGMTEGFDVGLEMS
GAPPAFRTLLNAMNHGGRIAMLGIPPSDMSIDWNQVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLTPIITHRFTIDQ
FQQGFDAMRSGQSGKVVLSWD

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=26.9461077844311, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=24.3967828418231, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI34577061, Length=349, Percent_Identity=25.5014326647564, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI262073058, Length=355, Percent_Identity=26.4788732394366, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=25, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI71743840, Length=355, Percent_Identity=26.4788732394366, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI156523966, Length=349, Percent_Identity=23.7822349570201, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=23.9067055393586, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71565154, Length=348, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=92.6686217008798, Blast_Score=666, Evalue=0.0,
Organism=Escherichia coli, GI1788075, Length=368, Percent_Identity=31.25, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=28.2674772036474, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1787863, Length=318, Percent_Identity=29.874213836478, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87082125, Length=353, Percent_Identity=30.8781869688385, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI226510992, Length=330, Percent_Identity=26.969696969697, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=26.8221574344023, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87081918, Length=286, Percent_Identity=30.0699300699301, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786825, Length=400, Percent_Identity=27.5, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1790718, Length=321, Percent_Identity=25.8566978193146, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1786552, Length=358, Percent_Identity=26.536312849162, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786518, Length=283, Percent_Identity=26.8551236749117, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=31.6417910447761, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=30.8383233532934, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17562584, Length=283, Percent_Identity=26.5017667844523, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=25.668449197861, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=374, Percent_Identity=25.4010695187166, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=187, Percent_Identity=31.0160427807487, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=143, Percent_Identity=32.8671328671329, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323099, Length=323, Percent_Identity=30.9597523219814, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6322619, Length=309, Percent_Identity=28.1553398058252, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=309, Percent_Identity=27.831715210356, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319258, Length=373, Percent_Identity=26.8096514745308, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319257, Length=318, Percent_Identity=25.7861635220126, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=26.4305177111717, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=278, Percent_Identity=28.7769784172662, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=325, Percent_Identity=28, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=330, Percent_Identity=27.8787878787879, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=285, Percent_Identity=28.7719298245614, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=258, Percent_Identity=30.6201550387597, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=327, Percent_Identity=25.0764525993884, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=26.2048192771084, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=25.9036144578313, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=25.1989389920424, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45551930, Length=191, Percent_Identity=27.2251308900524, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221457811, Length=191, Percent_Identity=27.2251308900524, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550770, Length=191, Percent_Identity=27.2251308900524, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37295; Mature: 37295

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALSKLKAEEGIWMTDVPQPELGHNDIMIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCCCCCEEE
VGHEYVGEVVAIGQEVKGFTVGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGS
ECHHHHHHHHHHCCCCCCEEECCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCCC
FAEYLVIPAFNAFKIPDNISDELASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAA
CEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVCKHVGARHVVITDVNEYRLDLARKMGVTRAVNVSKENLNDVMAELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRTLLNAMNHGGRIAMLGIPPSDMSIDWNQVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLTPIITHRFTIDQFQQGFDAMRSGQSGKVVLSWD
HHHCCCCCCCHHEEEEEHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKALSKLKAEEGIWMTDVPQPELGHNDIMIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCCCCCEEE
VGHEYVGEVVAIGQEVKGFTVGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGS
ECHHHHHHHHHHCCCCCCEEECCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCCC
FAEYLVIPAFNAFKIPDNISDELASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAA
CEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVCKHVGARHVVITDVNEYRLDLARKMGVTRAVNVSKENLNDVMAELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRTLLNAMNHGGRIAMLGIPPSDMSIDWNQVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLTPIITHRFTIDQFQQGFDAMRSGQSGKVVLSWD
HHHCCCCCCCHHEEEEEHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]