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The map label for this gene is ilvA [H]

Identifier: 157372988

GI number: 157372988

Start: 5260582

End: 5262126

Strand: Reverse

Name: ilvA [H]

Synonym: Spro_4756

Alternate gene names: 157372988

Gene position: 5262126-5260582 (Counterclockwise)

Preceding gene: 157372989

Following gene: 157372987

Centisome position: 96.57

GC content: 60.32

Gene sequence:

>1545_bases
ATGGCGGTATCGCAACCCCTACCCGACGCCCCCTGTGGCGCCGAGTATTTGCGAGCGGTGCTCCGCTCGCCGGTTTACGA
GGTGGCTCAGGTCACCCCGTTGCAGACCATGAGCAAAATCTCTTCGCGGCTCGGCAATACTATTTTGGTGAAGCGCGAAG
ATCGTCAGCCAGTACACAGCTTCAAGCTGCGTGGGGCCTACGCGATGATCGCCAGCCTGAACGAAGAGCAAAAGGCGCGC
GGCGTGGTGACGGCTTCGGCCGGCAACCATGCGCAGGGCGTGGCCTATTCAGGCAAACGGCTGGGGATCAAAACGCTGAT
CGTGATGCCGGTGACCACCGCAGACATCAAAGTGGATGCGGTACGCGGCTTTGGTGGCGAGGTGCTGTTGCACGGCGCCA
ACTTTGATGAAGCCAAGGCCAGAGCGATAGAGCTTTCACTCAAGCAGGGCATGACCTTCGTGCCGCCGTTCGACCACCCA
ACGGTGATCGCCGGGCAGGGCACGCTGGCGATGGAACTGCTGCAGCAGGACGCTCATCTCGACCGGGTGTTTGTTCCGGT
TGGCGGTGGCGGTCTGGCGGCGGGCGTGGCGGTATTAATCAAGCAACTGATGCCGCAGATTAAGGTGATCGGCGTGGAGG
CGGAAGACTCTGCCTGCCTGCGCGCGGCGCTGGATGCCGGACATCCGGTGGATTTGGCGCGTGTTGGGCTGTTTGCCGAA
GGCGTGGCGGTAAAGCGCATCGGTGACGAAACCTTCCGCCTGTGTCGGGAATACCTGGACGACGTGATCACCGTCGACAG
CGATGCTATCTGCGCCGCGGTCAAGGATCTGTTTGAAGACGTGCGCGCCATTGCCGAGCCGTCCGGTGCGCTGGCGCTGG
CCGGGCTGAAAAAGTATGTGCAGCAGCACAATATTCAGGGTGAACGCCTGGCGCACGTGTTGTCCGGCGCCAACCTGAAC
TTCCACGGTTTGCGCTATGTGTCGGAACGCTGCGAACTGGGCGAACAACGCGAAGCCCTGTTGGCGGTCACCATTCCTGA
GCAGAAAGGCAGTTTCCTGAAGTTTTGCCAACTGCTGGGCGGGCGCTCGGTCACCGAGTTCAACTACCGTTACGCCGATG
CCGATAACGCCTGTATTTTCGTCGGTGTCCGCCTGACGCGCGGCCATGCCGAACGCCTGGAAATCATCGATGAACTGCAG
GCCGATGGTTATCAGGTGGTGGATCTATCCGACGATGAAATGGCCAAGCTGCACGTGCGTTATATGGTGGGGGGGCGTCC
TTCGAAGCCGTTGCGCGAGCGTCTGTACAGCTTCGAATTCCCGGAGTCACCGGGCGCACTGCTGAAGTTCTTGCAGACGT
TGGGCACCCATTGGAATATTTCACTGTTCCATTATCGCAGTCACGGCACCGATTTTGGCCGCGTGCTGGCCGGTTTTGAA
CTGTCGCAGACCGAACCCGAGTTTGAGCAGCACCTGCAGGCGCTGGGCTATGACTGCCACGATGAAACCGACAACCCGGC
GTTCCGCTTCTTTTTGCAGGGTTGA

Upstream 100 bases:

>100_bases
AGCGCCAGGTTTCCTTCGCTCTGCGCGCCTACGCCACACTGGCGACCAGCGCGGACAAAGGCGCTGTACGCGACAAGAGC
AAGCTGGGAGGCTAAGCATC

Downstream 100 bases:

>100_bases
TAAGAAATACATAAGTAATCGTGACCTATAAGCCAGTTTATAGGTTGCGTTGTTGTGATTTTGTTGTGCATTTTTATACT
GCCAAGACTTTTGACGTATA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MAVSQPLPDAPCGAEYLRAVLRSPVYEVAQVTPLQTMSKISSRLGNTILVKREDRQPVHSFKLRGAYAMIASLNEEQKAR
GVVTASAGNHAQGVAYSGKRLGIKTLIVMPVTTADIKVDAVRGFGGEVLLHGANFDEAKARAIELSLKQGMTFVPPFDHP
TVIAGQGTLAMELLQQDAHLDRVFVPVGGGGLAAGVAVLIKQLMPQIKVIGVEAEDSACLRAALDAGHPVDLARVGLFAE
GVAVKRIGDETFRLCREYLDDVITVDSDAICAAVKDLFEDVRAIAEPSGALALAGLKKYVQQHNIQGERLAHVLSGANLN
FHGLRYVSERCELGEQREALLAVTIPEQKGSFLKFCQLLGGRSVTEFNYRYADADNACIFVGVRLTRGHAERLEIIDELQ
ADGYQVVDLSDDEMAKLHVRYMVGGRPSKPLRERLYSFEFPESPGALLKFLQTLGTHWNISLFHYRSHGTDFGRVLAGFE
LSQTEPEFEQHLQALGYDCHDETDNPAFRFFLQG

Sequences:

>Translated_514_residues
MAVSQPLPDAPCGAEYLRAVLRSPVYEVAQVTPLQTMSKISSRLGNTILVKREDRQPVHSFKLRGAYAMIASLNEEQKAR
GVVTASAGNHAQGVAYSGKRLGIKTLIVMPVTTADIKVDAVRGFGGEVLLHGANFDEAKARAIELSLKQGMTFVPPFDHP
TVIAGQGTLAMELLQQDAHLDRVFVPVGGGGLAAGVAVLIKQLMPQIKVIGVEAEDSACLRAALDAGHPVDLARVGLFAE
GVAVKRIGDETFRLCREYLDDVITVDSDAICAAVKDLFEDVRAIAEPSGALALAGLKKYVQQHNIQGERLAHVLSGANLN
FHGLRYVSERCELGEQREALLAVTIPEQKGSFLKFCQLLGGRSVTEFNYRYADADNACIFVGVRLTRGHAERLEIIDELQ
ADGYQVVDLSDDEMAKLHVRYMVGGRPSKPLRERLYSFEFPESPGALLKFLQTLGTHWNISLFHYRSHGTDFGRVLAGFE
LSQTEPEFEQHLQALGYDCHDETDNPAFRFFLQG
>Mature_513_residues
AVSQPLPDAPCGAEYLRAVLRSPVYEVAQVTPLQTMSKISSRLGNTILVKREDRQPVHSFKLRGAYAMIASLNEEQKARG
VVTASAGNHAQGVAYSGKRLGIKTLIVMPVTTADIKVDAVRGFGGEVLLHGANFDEAKARAIELSLKQGMTFVPPFDHPT
VIAGQGTLAMELLQQDAHLDRVFVPVGGGGLAAGVAVLIKQLMPQIKVIGVEAEDSACLRAALDAGHPVDLARVGLFAEG
VAVKRIGDETFRLCREYLDDVITVDSDAICAAVKDLFEDVRAIAEPSGALALAGLKKYVQQHNIQGERLAHVLSGANLNF
HGLRYVSERCELGEQREALLAVTIPEQKGSFLKFCQLLGGRSVTEFNYRYADADNACIFVGVRLTRGHAERLEIIDELQA
DGYQVVDLSDDEMAKLHVRYMVGGRPSKPLRERLYSFEFPESPGALLKFLQTLGTHWNISLFHYRSHGTDFGRVLAGFEL
SQTEPEFEQHLQALGYDCHDETDNPAFRFFLQG

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=296, Percent_Identity=33.1081081081081, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI19923959, Length=311, Percent_Identity=32.1543408360129, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI33469958, Length=314, Percent_Identity=26.1146496815287, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI1790207, Length=514, Percent_Identity=85.408560311284, Blast_Score=879, Evalue=0.0,
Organism=Escherichia coli, GI1789505, Length=288, Percent_Identity=38.5416666666667, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1789235, Length=226, Percent_Identity=27.8761061946903, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=403, Percent_Identity=30.272952853598, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17537387, Length=314, Percent_Identity=34.3949044585987, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17508781, Length=289, Percent_Identity=30.1038062283737, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17535051, Length=270, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320930, Length=515, Percent_Identity=48.1553398058252, Blast_Score=470, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322631, Length=304, Percent_Identity=34.2105263157895, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6319788, Length=266, Percent_Identity=27.0676691729323, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21355833, Length=322, Percent_Identity=32.6086956521739, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24645328, Length=251, Percent_Identity=29.4820717131474, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 56241; Mature: 56110

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSQPLPDAPCGAEYLRAVLRSPVYEVAQVTPLQTMSKISSRLGNTILVKREDRQPVHS
CCCCCCCCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCHHH
FKLRGAYAMIASLNEEQKARGVVTASAGNHAQGVAYSGKRLGIKTLIVMPVTTADIKVDA
HHHCHHHHHHHHCCHHHHHCEEEEECCCCCCCCEEECCCCCCEEEEEEEEEEECCEEEEE
VRGFGGEVLLHGANFDEAKARAIELSLKQGMTFVPPFDHPTVIAGQGTLAMELLQQDAHL
ECCCCCEEEEECCCCCHHHHHEEEEHHHCCCEECCCCCCCEEEECCCHHHHHHHHHCCCC
DRVFVPVGGGGLAAGVAVLIKQLMPQIKVIGVEAEDSACLRAALDAGHPVDLARVGLFAE
CEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHC
GVAVKRIGDETFRLCREYLDDVITVDSDAICAAVKDLFEDVRAIAEPSGALALAGLKKYV
CCHHHHCCHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QQHNIQGERLAHVLSGANLNFHGLRYVSERCELGEQREALLAVTIPEQKGSFLKFCQLLG
HHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHC
GRSVTEFNYRYADADNACIFVGVRLTRGHAERLEIIDELQADGYQVVDLSDDEMAKLHVR
CCCEEECCEEECCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEE
YMVGGRPSKPLRERLYSFEFPESPGALLKFLQTLGTHWNISLFHYRSHGTDFGRVLAGFE
EEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHCCC
LSQTEPEFEQHLQALGYDCHDETDNPAFRFFLQG
CCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
AVSQPLPDAPCGAEYLRAVLRSPVYEVAQVTPLQTMSKISSRLGNTILVKREDRQPVHS
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCHHH
FKLRGAYAMIASLNEEQKARGVVTASAGNHAQGVAYSGKRLGIKTLIVMPVTTADIKVDA
HHHCHHHHHHHHCCHHHHHCEEEEECCCCCCCCEEECCCCCCEEEEEEEEEEECCEEEEE
VRGFGGEVLLHGANFDEAKARAIELSLKQGMTFVPPFDHPTVIAGQGTLAMELLQQDAHL
ECCCCCEEEEECCCCCHHHHHEEEEHHHCCCEECCCCCCCEEEECCCHHHHHHHHHCCCC
DRVFVPVGGGGLAAGVAVLIKQLMPQIKVIGVEAEDSACLRAALDAGHPVDLARVGLFAE
CEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHC
GVAVKRIGDETFRLCREYLDDVITVDSDAICAAVKDLFEDVRAIAEPSGALALAGLKKYV
CCHHHHCCHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QQHNIQGERLAHVLSGANLNFHGLRYVSERCELGEQREALLAVTIPEQKGSFLKFCQLLG
HHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHC
GRSVTEFNYRYADADNACIFVGVRLTRGHAERLEIIDELQADGYQVVDLSDDEMAKLHVR
CCCEEECCEEECCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEE
YMVGGRPSKPLRERLYSFEFPESPGALLKFLQTLGTHWNISLFHYRSHGTDFGRVLAGFE
EEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHCCC
LSQTEPEFEQHLQALGYDCHDETDNPAFRFFLQG
CCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3315862; 3550695; 1379743; 9278503; 3003115; 2473940; 9562556 [H]