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The map label for this gene is ilvD

Identifier: 157372989

GI number: 157372989

Start: 5262132

End: 5263982

Strand: Reverse

Name: ilvD

Synonym: Spro_4757

Alternate gene names: 157372989

Gene position: 5263982-5262132 (Counterclockwise)

Preceding gene: 157372990

Following gene: 157372988

Centisome position: 96.61

GC content: 59.43

Gene sequence:

>1851_bases
ATGCCTAAGTACCGTTCCGCCACCACCACCCACGGCCGCAACATGGCGGGTGCCCGCGCATTATGGCGCGCGACCGGAAT
GACCGACGACGATTTTGGCAAACCCATTATTGCGGTGGTCAACTCATTTACCCAGTTCGTTCCGGGCCATGTGCACCTGC
GTGATTTGGGCAAACTGGTTGCAGAACAGATCGAGGCCTCAGGTGGCGTAGCCAAAGAGTTCAACACCATTGCGGTGGAT
GACGGTATCGCCATGGGCCACGGCGGCATGCTCTATTCCCTGCCGTCGCGCGAATTGATCGCCGACTCGGTTGAATACAT
GGTGAATGCCCACTGCGCGGATGCGATGGTGTGTATCTCCAACTGCGACAAGATCACCCCAGGGATGCTGATGGCGTCAC
TGCGCCTGAATATTCCGGTGATTTTCGTTTCCGGCGGCCCGATGGAAGCCGGCAAAACCAAGCTTTCCGACAAGATCATC
AAGCTGGATCTGATCGACGCCATGATCCAGGGCGCCAACCCGAACGTCAGCGATGCCGACAGCGCGCAGATCGAACGTTC
CGCCTGTCCGACCTGCGGCTCCTGTTCCGGTATGTTCACCGCCAACTCGATGAACTGCCTGACCGAAGCCCTGGGCCTGT
CCCAACCGGGCAACGGCTCGCTGCTGGCGACCCACGCTGACCGTAAGGATCTGTTCCTCAACGCCGGCAAACGCATCGTT
GCGCTGACCAAGCGCTACTACGAGCAGGACGACGAAAGCGCACTGCCACGCAGCATCGCCAACAAGGCCGCATTCGAAAA
CGCCATGACGCTGGACATTGCCATGGGCGGTTCGACCAACACCGTGTTGCACCTGTTGGCGGCGGCTCAGGAAGGTGAAA
TTGATTTCACCATGGAAGATATCGATCGCCTGTCGCGCAAGGTACCGCACCTGTGCAAAGTGGCGCCAAGCACTCAGAAA
TACCATATGGAAGACGTACACCGTGCCGGTGGCGTACTGGCGATTCTGGGTGAGCTGGATCGTGCGGGTCTGATGAATCG
CGACGTCGATAACATCCTGGGCCTGAAGCTGACGGAAACGCTGAACCAGTACGACATCATGCTGACTCAGGACGAAGCGG
TGAAGAAAATGTTCCGCGCCGGTCCAGCGGGTATCCGTACCACCCAGGCGTTCTCGCAGGATTGCCGCTGGGACACGCTG
GACGATGACCGCGCAGAAGGCTGTATCCGTTCGCTGGAAAATGCCTTCAGCCTGGAAGGTGGCCTGGCCGTGTTGTACGG
CAACATGGCACTGGACGGCAGCATTGTGAAAACCGCCGGTGTCGATAAAGACAACCTGACCTTCCGTGGCCCGGCCAAAG
TGTATGAAAGCCAGGACACTGCGGTAGAAGCGATCCTCGGCGGCAAAGTGGTTGCCGGCGACGTAGTGGTGATTCGCTAT
GAAGGGCCGAAGGGCGGGCCGGGCATGCAGGAAATGCTCTATCCAACCACCTACCTGAAATCCATGGGCCTGGGTAAGGC
CTGTGCGCTGATCACCGACGGTCGCTTCTCTGGCGGGACTTCGGGTCTGTCTATCGGCCACGTATCTCCGGAAGCGGGCA
GCGGCGGTCTGATTGCGCTGATCGAAGACGGCGACATGATCGACATCGATATTCCAAAACGCAGCATGGTGCTGGATGTC
AGCGACAGCGAACTGGCGGCACGCCGCGAAGTTGAACTGGCACGTGGCGATCGGGCCTGGACACCGAAAAACCGTGAGCG
CCAGGTTTCCTTCGCTCTGCGCGCCTACGCCACACTGGCGACCAGCGCGGACAAAGGCGCTGTACGCGACAAGAGCAAGC
TGGGAGGCTAA

Upstream 100 bases:

>100_bases
TTACCCGCAACCTGAAAGGCAACGGGTAAATCGACAGACAGATAAGAATATCCAGGCGGTTCGTTCGCCGCCTGTAATAA
ATACATTTGGAGTGAAGAGC

Downstream 100 bases:

>100_bases
GCATCATGGCGGTATCGCAACCCCTACCCGACGCCCCCTGTGGCGCCGAGTATTTGCGAGCGGTGCTCCGCTCGCCGGTT
TACGAGGTGGCTCAGGTCAC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MPKYRSATTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKII
KLDLIDAMIQGANPNVSDADSAQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKDLFLNAGKRIV
ALTKRYYEQDDESALPRSIANKAAFENAMTLDIAMGGSTNTVLHLLAAAQEGEIDFTMEDIDRLSRKVPHLCKVAPSTQK
YHMEDVHRAGGVLAILGELDRAGLMNRDVDNILGLKLTETLNQYDIMLTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDTL
DDDRAEGCIRSLENAFSLEGGLAVLYGNMALDGSIVKTAGVDKDNLTFRGPAKVYESQDTAVEAILGGKVVAGDVVVIRY
EGPKGGPGMQEMLYPTTYLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAGSGGLIALIEDGDMIDIDIPKRSMVLDV
SDSELAARREVELARGDRAWTPKNRERQVSFALRAYATLATSADKGAVRDKSKLGG

Sequences:

>Translated_616_residues
MPKYRSATTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKII
KLDLIDAMIQGANPNVSDADSAQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKDLFLNAGKRIV
ALTKRYYEQDDESALPRSIANKAAFENAMTLDIAMGGSTNTVLHLLAAAQEGEIDFTMEDIDRLSRKVPHLCKVAPSTQK
YHMEDVHRAGGVLAILGELDRAGLMNRDVDNILGLKLTETLNQYDIMLTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDTL
DDDRAEGCIRSLENAFSLEGGLAVLYGNMALDGSIVKTAGVDKDNLTFRGPAKVYESQDTAVEAILGGKVVAGDVVVIRY
EGPKGGPGMQEMLYPTTYLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAGSGGLIALIEDGDMIDIDIPKRSMVLDV
SDSELAARREVELARGDRAWTPKNRERQVSFALRAYATLATSADKGAVRDKSKLGG
>Mature_615_residues
PKYRSATTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIK
LDLIDAMIQGANPNVSDADSAQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKDLFLNAGKRIVA
LTKRYYEQDDESALPRSIANKAAFENAMTLDIAMGGSTNTVLHLLAAAQEGEIDFTMEDIDRLSRKVPHLCKVAPSTQKY
HMEDVHRAGGVLAILGELDRAGLMNRDVDNILGLKLTETLNQYDIMLTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDTLD
DDRAEGCIRSLENAFSLEGGLAVLYGNMALDGSIVKTAGVDKDNLTFRGPAKVYESQDTAVEAILGGKVVAGDVVVIRYE
GPKGGPGMQEMLYPTTYLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAGSGGLIALIEDGDMIDIDIPKRSMVLDVS
DSELAARREVELARGDRAWTPKNRERQVSFALRAYATLATSADKGAVRDKSKLGG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=616, Percent_Identity=89.6103896103896, Blast_Score=1144, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=540, Percent_Identity=29.8148148148148, Blast_Score=185, Evalue=7e-48,
Organism=Escherichia coli, GI2367371, Length=562, Percent_Identity=29.3594306049822, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI1786464, Length=526, Percent_Identity=28.8973384030418, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322476, Length=615, Percent_Identity=35.7723577235772, Blast_Score=329, Evalue=8e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_SERP5 (A8GL60)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480978.1
- STRING:   A8GL60
- GeneID:   5604255
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4757
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- BioCyc:   SPRO399741:SPRO_4757-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65827; Mature: 65696

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYRSATTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLIDAMIQGANPNVSDAD
CCCCCCHHHHHHEEECCCEEEEEECCCCCCCCHHHHCCEEEHHHHHHHHCCCCCCCCCCC
SAQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKDLFLNAGKRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHCCCHHH
ALTKRYYEQDDESALPRSIANKAAFENAMTLDIAMGGSTNTVLHLLAAAQEGEIDFTMED
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEHHH
IDRLSRKVPHLCKVAPSTQKYHMEDVHRAGGVLAILGELDRAGLMNRDVDNILGLKLTET
HHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCHHHHHCCHHHHH
LNQYDIMLTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDTLDDDRAEGCIRSLENAFSLEG
HCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GLAVLYGNMALDGSIVKTAGVDKDNLTFRGPAKVYESQDTAVEAILGGKVVAGDVVVIRY
CEEEEEECEEECCCEEEECCCCCCCCEECCCHHHHCCCCHHHHHHHCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTTYLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAGSGGLIAL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCEEEE
IEDGDMIDIDIPKRSMVLDVSDSELAARREVELARGDRAWTPKNRERQVSFALRAYATLA
EECCCEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
TSADKGAVRDKSKLGG
CCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PKYRSATTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLIDAMIQGANPNVSDAD
CCCCCCHHHHHHEEECCCEEEEEECCCCCCCCHHHHCCEEEHHHHHHHHCCCCCCCCCCC
SAQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKDLFLNAGKRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHCCCHHH
ALTKRYYEQDDESALPRSIANKAAFENAMTLDIAMGGSTNTVLHLLAAAQEGEIDFTMED
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEHHH
IDRLSRKVPHLCKVAPSTQKYHMEDVHRAGGVLAILGELDRAGLMNRDVDNILGLKLTET
HHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCHHHHHCCHHHHH
LNQYDIMLTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDTLDDDRAEGCIRSLENAFSLEG
HCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GLAVLYGNMALDGSIVKTAGVDKDNLTFRGPAKVYESQDTAVEAILGGKVVAGDVVVIRY
CEEEEEECEEECCCEEEECCCCCCCCEECCCHHHHCCCCHHHHHHHCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTTYLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAGSGGLIAL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCEEEE
IEDGDMIDIDIPKRSMVLDVSDSELAARREVELARGDRAWTPKNRERQVSFALRAYATLA
EECCCEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
TSADKGAVRDKSKLGG
CCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA