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The map label for this gene is luxQ [H]

Identifier: 157372967

GI number: 157372967

Start: 5231229

End: 5233013

Strand: Direct

Name: luxQ [H]

Synonym: Spro_4735

Alternate gene names: 157372967

Gene position: 5231229-5233013 (Clockwise)

Preceding gene: 157372966

Following gene: 157372972

Centisome position: 96.01

GC content: 54.17

Gene sequence:

>1785_bases
ATGAAGCTCACAGGGTTTAAAAGCAACAGCAGGCTGGCGATCCCGGCTATTTTTGCCGCACTGTTTTTGGTTGCCTCTAC
GGTGACGCTGTATTACTACAGCGCAACCCTGTCAAAGAAGGGGCTGTATGCTATCGCCGGCACCCAGGAGAATTACTCCT
GGTCGATCGCCAAGTTCTCCATCAAGCTGGCCGAGTTTGATACGCTGGTCGAACAGCTGAAAAATGCGCCGCAGGTGGAC
GCCGAGGCTCTGCGGCTTAAATTTGAAATCCTTTACTCTCGCTTTTACGTGCTGGAAACGGTGTCCGAATCCACCCAGCC
ACTGTACGCCGAACCGGGTTATCCCGAGGTGGTCACGCACATGCGCGAGAAAATGGATCAGATTGATCATTTGCTCAACA
GCCCGAAGATTGATTTCTCGTTGATTTCGCAGGCCATGAGGCAGATTAAGCCCTATGCGATTGAGATGGCCAACCTGACC
GATCACGCTGAAGTGAAGCAGCGCACCGCCGCCTACGAAGACTATATCGAAAAACGACACATCATTTTTTATGGTCTGGT
GATCGTGATGTTCTCGGTGATCGCGCTGATCGCCATCACCCTGATTGTGCTGCGCCAGCAGCGCCTGACAATCCGGCAGC
AGGCCAAAGCGATTGAGGCAGAGAAAGCCACTCGCACCAAAAACGCCTTCCTGGGGGCCATTGGTCACGAACTGCGCACC
TCGCTGCAAAGTATTATGTCTGCCATTGATGTGCTGGTGAATACCAAGGTGTCGGCCGAACATGCGGACACCTTCCAACG
TCTGGAAACTGCCGCGCAGCAAATTGAAAGCCAGATGAAAGATCTGACCGATTACGCGCACCTGGACAGCGGAATGATGG
AGCTGCGCATCGCCCCCTTCGACGTTCAGCGGCTGGTCGAGGAAACCGCAAATGAAATCAATACGCTGAGTCAGAAAGAT
CAGGTGACGCTGTTGTGTGAAGTGGAGTGCGGTCATCTGCAGATACATTCCGATCCACTGCGCATCAGGCAAATTATCGT
CAACCTGCTGACCAACGCGTTCAAATATACCGAAAGCGGCACCATCACGCTGTATAGCAGCCTGCGGCGCCAGCCAAACG
GCAATGCATTGATTATTGAGGTCACGGATACCGGTATCGGTATCGAAAAGGAGATGCTCGACCAGATATTCCAGCCCTTC
ACCCAGCTCGATCAGTCGCATACCCGGCAGTATGGCGGCGTCGGCATGGGGCTGGCGATTGTACACGGACTGGTCACGCT
GCTCGACGGCAGCATTACCGTCTACAGTGAGCCCAAAAAAGGCAGCACCTTCATCGTCAGTATTCCGGTTGAAGTCAGCA
ACGAAGAACGGCTCGACGAAATACCTCACCACCACCATAGCCTGCTGCAAAAACAGCAGCATATTTTGGTGGTTGATGAC
AACAAATCGGTGAGTGACGCCTTCGCGGCGCTGCTGGACAAGCTCGGCTATCAACATGAACTGTGCAATTCGTCGGAACG
GGCGCTGCAAAAGCTGCTCCGTCGCCCTTATGACGCATTACTGCTGGATCTGCAAATGCCCGGCATTGACGGTGCCGCGC
TGGCTAAACAATTACGCAGCCAACGTGGCCCCAACCGTGGTATTCCGATCGTGGGCATTAGCGCTTACACCCCGGAACAA
CTGTCTGCCGAACAGCGGGCGCTGTTCGACAATTACCTGATGAAGCCGGTCAGGCTGGACGCGTTGTCTTCCGCACTGGC
TTCACTGCTGGCCGCTAGAGATTAA

Upstream 100 bases:

>100_bases
CGCTGTTTTTGGTTTATCCCAGGGATGCCGCAGGGCCTGAGTTGAATTCCCCGCTCTACAACTCACGCTTTATCTGGCAA
GTGGACAGGATTGTGATCAA

Downstream 100 bases:

>100_bases
AACAGCGCAACAGTGCGGCTTCAATCACATGGAGCCGTACTGGCTTTTCATAAGGGCCCAGTACGTCATAGTCGCGCATC
GCCCTGGCGATTTCAGATTC

Product: integral membrane sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MKLTGFKSNSRLAIPAIFAALFLVASTVTLYYYSATLSKKGLYAIAGTQENYSWSIAKFSIKLAEFDTLVEQLKNAPQVD
AEALRLKFEILYSRFYVLETVSESTQPLYAEPGYPEVVTHMREKMDQIDHLLNSPKIDFSLISQAMRQIKPYAIEMANLT
DHAEVKQRTAAYEDYIEKRHIIFYGLVIVMFSVIALIAITLIVLRQQRLTIRQQAKAIEAEKATRTKNAFLGAIGHELRT
SLQSIMSAIDVLVNTKVSAEHADTFQRLETAAQQIESQMKDLTDYAHLDSGMMELRIAPFDVQRLVEETANEINTLSQKD
QVTLLCEVECGHLQIHSDPLRIRQIIVNLLTNAFKYTESGTITLYSSLRRQPNGNALIIEVTDTGIGIEKEMLDQIFQPF
TQLDQSHTRQYGGVGMGLAIVHGLVTLLDGSITVYSEPKKGSTFIVSIPVEVSNEERLDEIPHHHHSLLQKQQHILVVDD
NKSVSDAFAALLDKLGYQHELCNSSERALQKLLRRPYDALLLDLQMPGIDGAALAKQLRSQRGPNRGIPIVGISAYTPEQ
LSAEQRALFDNYLMKPVRLDALSSALASLLAARD

Sequences:

>Translated_594_residues
MKLTGFKSNSRLAIPAIFAALFLVASTVTLYYYSATLSKKGLYAIAGTQENYSWSIAKFSIKLAEFDTLVEQLKNAPQVD
AEALRLKFEILYSRFYVLETVSESTQPLYAEPGYPEVVTHMREKMDQIDHLLNSPKIDFSLISQAMRQIKPYAIEMANLT
DHAEVKQRTAAYEDYIEKRHIIFYGLVIVMFSVIALIAITLIVLRQQRLTIRQQAKAIEAEKATRTKNAFLGAIGHELRT
SLQSIMSAIDVLVNTKVSAEHADTFQRLETAAQQIESQMKDLTDYAHLDSGMMELRIAPFDVQRLVEETANEINTLSQKD
QVTLLCEVECGHLQIHSDPLRIRQIIVNLLTNAFKYTESGTITLYSSLRRQPNGNALIIEVTDTGIGIEKEMLDQIFQPF
TQLDQSHTRQYGGVGMGLAIVHGLVTLLDGSITVYSEPKKGSTFIVSIPVEVSNEERLDEIPHHHHSLLQKQQHILVVDD
NKSVSDAFAALLDKLGYQHELCNSSERALQKLLRRPYDALLLDLQMPGIDGAALAKQLRSQRGPNRGIPIVGISAYTPEQ
LSAEQRALFDNYLMKPVRLDALSSALASLLAARD
>Mature_594_residues
MKLTGFKSNSRLAIPAIFAALFLVASTVTLYYYSATLSKKGLYAIAGTQENYSWSIAKFSIKLAEFDTLVEQLKNAPQVD
AEALRLKFEILYSRFYVLETVSESTQPLYAEPGYPEVVTHMREKMDQIDHLLNSPKIDFSLISQAMRQIKPYAIEMANLT
DHAEVKQRTAAYEDYIEKRHIIFYGLVIVMFSVIALIAITLIVLRQQRLTIRQQAKAIEAEKATRTKNAFLGAIGHELRT
SLQSIMSAIDVLVNTKVSAEHADTFQRLETAAQQIESQMKDLTDYAHLDSGMMELRIAPFDVQRLVEETANEINTLSQKD
QVTLLCEVECGHLQIHSDPLRIRQIIVNLLTNAFKYTESGTITLYSSLRRQPNGNALIIEVTDTGIGIEKEMLDQIFQPF
TQLDQSHTRQYGGVGMGLAIVHGLVTLLDGSITVYSEPKKGSTFIVSIPVEVSNEERLDEIPHHHHSLLQKQQHILVVDD
NKSVSDAFAALLDKLGYQHELCNSSERALQKLLRRPYDALLLDLQMPGIDGAALAKQLRSQRGPNRGIPIVGISAYTPEQ
LSAEQRALFDNYLMKPVRLDALSSALASLLAARD

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87081816, Length=393, Percent_Identity=29.5165394402036, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1788713, Length=449, Percent_Identity=28.7305122494432, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI48994928, Length=378, Percent_Identity=29.3650793650794, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI145693157, Length=262, Percent_Identity=34.3511450381679, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=31.7796610169492, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787894, Length=242, Percent_Identity=30.1652892561983, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=28.8888888888889, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790436, Length=296, Percent_Identity=25, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1786783, Length=261, Percent_Identity=28.3524904214559, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=23.9130434782609, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=25.1082251082251, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786912, Length=295, Percent_Identity=26.4406779661017, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=25.1082251082251, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=23.6734693877551, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=85, Percent_Identity=37.6470588235294, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66563; Mature: 66563

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTGFKSNSRLAIPAIFAALFLVASTVTLYYYSATLSKKGLYAIAGTQENYSWSIAKFS
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEE
IKLAEFDTLVEQLKNAPQVDAEALRLKFEILYSRFYVLETVSESTQPLYAEPGYPEVVTH
EHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
MREKMDQIDHLLNSPKIDFSLISQAMRQIKPYAIEMANLTDHAEVKQRTAAYEDYIEKRH
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHH
IIFYGLVIVMFSVIALIAITLIVLRQQRLTIRQQAKAIEAEKATRTKNAFLGAIGHELRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLQSIMSAIDVLVNTKVSAEHADTFQRLETAAQQIESQMKDLTDYAHLDSGMMELRIAPF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCH
DVQRLVEETANEINTLSQKDQVTLLCEVECGHLQIHSDPLRIRQIIVNLLTNAFKYTESG
HHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCCC
TITLYSSLRRQPNGNALIIEVTDTGIGIEKEMLDQIFQPFTQLDQSHTRQYGGVGMGLAI
CEEEEHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VHGLVTLLDGSITVYSEPKKGSTFIVSIPVEVSNEERLDEIPHHHHSLLQKQQHILVVDD
HHHHHHHHCCCEEEEECCCCCCEEEEEEEEECCCCHHHHHCCHHHHHHHHCCCCEEEEEC
NKSVSDAFAALLDKLGYQHELCNSSERALQKLLRRPYDALLLDLQMPGIDGAALAKQLRS
CCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCHHHEEEEEECCCCCHHHHHHHHHH
QRGPNRGIPIVGISAYTPEQLSAEQRALFDNYLMKPVRLDALSSALASLLAARD
HCCCCCCCCEEEECCCCCHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLTGFKSNSRLAIPAIFAALFLVASTVTLYYYSATLSKKGLYAIAGTQENYSWSIAKFS
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEE
IKLAEFDTLVEQLKNAPQVDAEALRLKFEILYSRFYVLETVSESTQPLYAEPGYPEVVTH
EHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
MREKMDQIDHLLNSPKIDFSLISQAMRQIKPYAIEMANLTDHAEVKQRTAAYEDYIEKRH
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHH
IIFYGLVIVMFSVIALIAITLIVLRQQRLTIRQQAKAIEAEKATRTKNAFLGAIGHELRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLQSIMSAIDVLVNTKVSAEHADTFQRLETAAQQIESQMKDLTDYAHLDSGMMELRIAPF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCH
DVQRLVEETANEINTLSQKDQVTLLCEVECGHLQIHSDPLRIRQIIVNLLTNAFKYTESG
HHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCCC
TITLYSSLRRQPNGNALIIEVTDTGIGIEKEMLDQIFQPFTQLDQSHTRQYGGVGMGLAI
CEEEEHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VHGLVTLLDGSITVYSEPKKGSTFIVSIPVEVSNEERLDEIPHHHHSLLQKQQHILVVDD
HHHHHHHHCCCEEEEECCCCCCEEEEEEEEECCCCHHHHHCCHHHHHHHHCCCCEEEEEC
NKSVSDAFAALLDKLGYQHELCNSSERALQKLLRRPYDALLLDLQMPGIDGAALAKQLRS
CCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCHHHEEEEEECCCCCHHHHHHHHHH
QRGPNRGIPIVGISAYTPEQLSAEQRALFDNYLMKPVRLDALSSALASLLAARD
HCCCCCCCCEEEECCCCCHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]