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The map label for this gene is shlB [H]

Identifier: 157372962

GI number: 157372962

Start: 5226688

End: 5228340

Strand: Direct

Name: shlB [H]

Synonym: Spro_4730

Alternate gene names: 157372962

Gene position: 5226688-5228340 (Clockwise)

Preceding gene: 157372961

Following gene: 157372965

Centisome position: 95.92

GC content: 48.46

Gene sequence:

>1653_bases
ATGAAAAAAAATATCCTATTACTGCTGAGTCTATTGCAAGCAGAGGGCACCCATGCCGGTAATCTGTTATCCACATTGGA
ACAACAGACTGTCAGCCAGGAAAATAAAGAGCGGAATATTCAGAACAAGCTGCAGCCTGGCGCTCCCACCGTATTCACCC
AACAGAGCGACACGCGCCAAAAGGCGCTCTTCTACCCGCAGGAGAACCCTTGCCTGATGATCCGTAAGGTGCAAATTGAA
AGTGGTGAAATGCGCCCAATCCCCGCCATTAGGCAATTGGCCAAGAGCGCCGAACACCAGTGTCTGGGCGCAACGGGAAT
AAGCAATCTGCAGAAGGCCATACAAAATCAGTTGATCGGCGAAGGGCTGATCACTTCACGTGCAGCGGTGACCGCCTATC
ATGCCAAAGAAGAGACTCTCACTCTTTCTCTGATTTATGGCCGCGTCAACAGCATCAAGCTGAGTGACGACAGCAGCGGG
CATTTCAATCTGGCCAGCGTTTTTCCGCTTAAAGCCGGCGACATACTCAATATCCGCAACGTTGAACAAGGGTTGGAAAA
CATCAACACCCTTCCCGGCACGCTGTCTGACATCCGTATTGCCCCCAGCCAAACGCCGGGAGAAAGTAAAATTGAAGTGC
TGCGCAAACAAGAGAAATATTGGCAGTTAGCGTCCTGGGTCGATAACTCTGGCACCAAAGCCACTGGCCGCAATCAGGGT
GGTGCCGCGCTTTTCCTCAACAATCTGACCTCGCTTAACGATACCCTTTACGCATCGCACTCCCAGAATATTGAGATATC
TGACACTCGCGGCAACAGTTCACACGCAATATCCTACTCCCTTCCCTATGGGTTCTGGTCAGTAGACCTGTTTGCGGGTA
AGAGTCAATATCATCAGAGTATTCCCGGCTATGCTGTTGACTACCAATATAAGGGGCAATCAGAAAGCCTCAGCCTGCAA
ATTGGCCGAACGGTATCACGCGGTGCTCGGTACAAAACCACGCTCAATGCGCAATTATTGGAGCGGGATTATCATTATTT
TATTAATGACACGGAAATAGACCTTCAGCGTAAACGCTTAACCAATATAAAAATTGGCGCCAAACACTTGCACTACATCG
ATGATGCAAGGGTTTCGTTATCGCTGGATATTTTGAAAAATATGCGATGGTTCCAGACCAATCATCTCGATGGCGCCTAT
AACTTAAGCAGCCACATTATTAAAGCCGAAGCCAGCGTATTTAATCCTTTCATGCTATCCAACCTTTCCATGGATTATAG
GGGCGGATTAACGCTGCAACTCACCAACTATGACTTGCCTATACAGGACAAGTTAGGCATTGGGAGCCGTAATACCGTGA
GAGGATTTGATGGCGAACTTAACTTGTTCGGCAACAAAGGCATCTACTGGCAAAATACGATGGCCTGGAACTTAAGTTCA
GTTCCGCTACAGCCCTATGTTGGCAGCGATTATGGCTATGTTATGCAGAGCGAGAACGCTGTTGGGCATAAGCTGGCAGG
CGGTATCGCAGGCGTAAGAATTGAAAAATGGAATACCAGCCTCGATACCTTTGTCGGTACCCCCCTCTATAAACCCCACG
GCTTCGCTACCAGCTCGATGAATATCGGTTTTTCACTGATATGGCGATATTAA

Upstream 100 bases:

>100_bases
CCACCGACAAACTCATGGTGGTCATCCTGGTGGTCCCGTAGCTGGTAATATTATTCCTCCGCCGCTCGGCGGAGGTTTTA
CCCTGACGTAAAAAATTAAT

Downstream 100 bases:

>100_bases
TGATGATGCCAAAAAACCGGGGCCGATAGCCAGCCCCCGTGGGCCCAGCTTAACGGGCCGGGTTGAAATGATCCCTGATA
AACACCGGCAAGTCGTTTGA

Product: hemolysin activator HlyB domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MKKNILLLLSLLQAEGTHAGNLLSTLEQQTVSQENKERNIQNKLQPGAPTVFTQQSDTRQKALFYPQENPCLMIRKVQIE
SGEMRPIPAIRQLAKSAEHQCLGATGISNLQKAIQNQLIGEGLITSRAAVTAYHAKEETLTLSLIYGRVNSIKLSDDSSG
HFNLASVFPLKAGDILNIRNVEQGLENINTLPGTLSDIRIAPSQTPGESKIEVLRKQEKYWQLASWVDNSGTKATGRNQG
GAALFLNNLTSLNDTLYASHSQNIEISDTRGNSSHAISYSLPYGFWSVDLFAGKSQYHQSIPGYAVDYQYKGQSESLSLQ
IGRTVSRGARYKTTLNAQLLERDYHYFINDTEIDLQRKRLTNIKIGAKHLHYIDDARVSLSLDILKNMRWFQTNHLDGAY
NLSSHIIKAEASVFNPFMLSNLSMDYRGGLTLQLTNYDLPIQDKLGIGSRNTVRGFDGELNLFGNKGIYWQNTMAWNLSS
VPLQPYVGSDYGYVMQSENAVGHKLAGGIAGVRIEKWNTSLDTFVGTPLYKPHGFATSSMNIGFSLIWRY

Sequences:

>Translated_550_residues
MKKNILLLLSLLQAEGTHAGNLLSTLEQQTVSQENKERNIQNKLQPGAPTVFTQQSDTRQKALFYPQENPCLMIRKVQIE
SGEMRPIPAIRQLAKSAEHQCLGATGISNLQKAIQNQLIGEGLITSRAAVTAYHAKEETLTLSLIYGRVNSIKLSDDSSG
HFNLASVFPLKAGDILNIRNVEQGLENINTLPGTLSDIRIAPSQTPGESKIEVLRKQEKYWQLASWVDNSGTKATGRNQG
GAALFLNNLTSLNDTLYASHSQNIEISDTRGNSSHAISYSLPYGFWSVDLFAGKSQYHQSIPGYAVDYQYKGQSESLSLQ
IGRTVSRGARYKTTLNAQLLERDYHYFINDTEIDLQRKRLTNIKIGAKHLHYIDDARVSLSLDILKNMRWFQTNHLDGAY
NLSSHIIKAEASVFNPFMLSNLSMDYRGGLTLQLTNYDLPIQDKLGIGSRNTVRGFDGELNLFGNKGIYWQNTMAWNLSS
VPLQPYVGSDYGYVMQSENAVGHKLAGGIAGVRIEKWNTSLDTFVGTPLYKPHGFATSSMNIGFSLIWRY
>Mature_550_residues
MKKNILLLLSLLQAEGTHAGNLLSTLEQQTVSQENKERNIQNKLQPGAPTVFTQQSDTRQKALFYPQENPCLMIRKVQIE
SGEMRPIPAIRQLAKSAEHQCLGATGISNLQKAIQNQLIGEGLITSRAAVTAYHAKEETLTLSLIYGRVNSIKLSDDSSG
HFNLASVFPLKAGDILNIRNVEQGLENINTLPGTLSDIRIAPSQTPGESKIEVLRKQEKYWQLASWVDNSGTKATGRNQG
GAALFLNNLTSLNDTLYASHSQNIEISDTRGNSSHAISYSLPYGFWSVDLFAGKSQYHQSIPGYAVDYQYKGQSESLSLQ
IGRTVSRGARYKTTLNAQLLERDYHYFINDTEIDLQRKRLTNIKIGAKHLHYIDDARVSLSLDILKNMRWFQTNHLDGAY
NLSSHIIKAEASVFNPFMLSNLSMDYRGGLTLQLTNYDLPIQDKLGIGSRNTVRGFDGELNLFGNKGIYWQNTMAWNLSS
VPLQPYVGSDYGYVMQSENAVGHKLAGGIAGVRIEKWNTSLDTFVGTPLYKPHGFATSSMNIGFSLIWRY

Specific function: Member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 61278; Mature: 61278

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNILLLLSLLQAEGTHAGNLLSTLEQQTVSQENKERNIQNKLQPGAPTVFTQQSDTRQ
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC
KALFYPQENPCLMIRKVQIESGEMRPIPAIRQLAKSAEHQCLGATGISNLQKAIQNQLIG
CEEECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHC
EGLITSRAAVTAYHAKEETLTLSLIYGRVNSIKLSDDSSGHFNLASVFPLKAGDILNIRN
CCHHHCCCEEEEEECCCCEEEEEEEECCCEEEEECCCCCCCEEEEEEEEECCCCEEEHHH
VEQGLENINTLPGTLSDIRIAPSQTPGESKIEVLRKQEKYWQLASWVDNSGTKATGRNQG
HHHHHHHHCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GAALFLNNLTSLNDTLYASHSQNIEISDTRGNSSHAISYSLPYGFWSVDLFAGKSQYHQS
CEEEEECCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEECCCCEEEEEEECCCHHHHHC
IPGYAVDYQYKGQSESLSLQIGRTVSRGARYKTTLNAQLLERDYHYFINDTEIDLQRKRL
CCCEEEEEEECCCCCCEEEEECCHHHCCCEEEEECCHHHHHCCCEEEECCCEEEEHHHHH
TNIKIGAKHLHYIDDARVSLSLDILKNMRWFQTNHLDGAYNLSSHIIKAEASVFNPFMLS
CCEEECHHHEEEECCCEEEEEHHHHHCCHHEECCCCCCCCCHHHHEEEEHHHHCCCHHHH
NLSMDYRGGLTLQLTNYDLPIQDKLGIGSRNTVRGFDGELNLFGNKGIYWQNTMAWNLSS
CCCCCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCCCCEEEEEECCCEEECCEEEECCCC
VPLQPYVGSDYGYVMQSENAVGHKLAGGIAGVRIEKWNTSLDTFVGTPLYKPHGFATSSM
CCCCCCCCCCCCEEEECCCCCCHHHHCCCCEEEEEECCCCHHHHCCCCCCCCCCCEECCC
NIGFSLIWRY
CCCEEEEEEC
>Mature Secondary Structure
MKKNILLLLSLLQAEGTHAGNLLSTLEQQTVSQENKERNIQNKLQPGAPTVFTQQSDTRQ
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC
KALFYPQENPCLMIRKVQIESGEMRPIPAIRQLAKSAEHQCLGATGISNLQKAIQNQLIG
CEEECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHC
EGLITSRAAVTAYHAKEETLTLSLIYGRVNSIKLSDDSSGHFNLASVFPLKAGDILNIRN
CCHHHCCCEEEEEECCCCEEEEEEEECCCEEEEECCCCCCCEEEEEEEEECCCCEEEHHH
VEQGLENINTLPGTLSDIRIAPSQTPGESKIEVLRKQEKYWQLASWVDNSGTKATGRNQG
HHHHHHHHCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GAALFLNNLTSLNDTLYASHSQNIEISDTRGNSSHAISYSLPYGFWSVDLFAGKSQYHQS
CEEEEECCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEECCCCEEEEEEECCCHHHHHC
IPGYAVDYQYKGQSESLSLQIGRTVSRGARYKTTLNAQLLERDYHYFINDTEIDLQRKRL
CCCEEEEEEECCCCCCEEEEECCHHHCCCEEEEECCHHHHHCCCEEEECCCEEEEHHHHH
TNIKIGAKHLHYIDDARVSLSLDILKNMRWFQTNHLDGAYNLSSHIIKAEASVFNPFMLS
CCEEECHHHEEEECCCEEEEEHHHHHCCHHEECCCCCCCCCHHHHEEEEHHHHCCCHHHH
NLSMDYRGGLTLQLTNYDLPIQDKLGIGSRNTVRGFDGELNLFGNKGIYWQNTMAWNLSS
CCCCCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCCCCEEEEEECCCEEECCEEEECCCC
VPLQPYVGSDYGYVMQSENAVGHKLAGGIAGVRIEKWNTSLDTFVGTPLYKPHGFATSSM
CCCCCCCCCCCCEEEECCCCCCHHHHCCCCEEEEEECCCCHHHHCCCCCCCCCCCEECCC
NIGFSLIWRY
CCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3290200 [H]