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The map label for this gene is gor [H]

Identifier: 157372946

GI number: 157372946

Start: 5208721

End: 5210073

Strand: Direct

Name: gor [H]

Synonym: Spro_4714

Alternate gene names: 157372946

Gene position: 5208721-5210073 (Clockwise)

Preceding gene: 157372945

Following gene: 157372958

Centisome position: 95.59

GC content: 56.61

Gene sequence:

>1353_bases
ATGACCAAACATTACGATTATCTAGCAATTGGCGGCGGCAGCGGCGGCATCGCATCGATCAACCGGGCAGCCATGTATGG
CCAGAAATGCGCACTGATTGAAGCCAAAGAACTGGGCGGCACCTGCGTCAACGTGGGTTGTGTACCGAAAAAAGTTATGT
GGCATGCGGCGCAAATCGCCGAGGCCATTCATATGTACGGCCCGGATTACGGTTTCGATACCACCGTCAACGCGTTTGAC
TGGAAAAAGCTGGTGGCTAACCGCACCGCTTATATCGACCGCATCCATAATTCCTACGACAACGTGCTGGGCAAAAACAA
AGTCGACGTGATCAAAGGCTTTGCGCGCTTTATCGACGCTAACACGGTGGAAGTCAACGGTGAGAAAATCACCGCCGATC
ATATTCTGATCGCCACTGGCGGACGCCCAAGCCACCCAGACATTCCGGGCGCAGAATACGGCATCGACTCCGACGGTTTC
TTCGAGCTGGACGCGATGCCAAAACGCGTTGCGGTCGTGGGCGCGGGCTATATCGCGGTGGAAATCGCCGGCGTGATGAA
CGCGCTGGGTGCCGAGACGCACCTGTTCGTGCGTAAACACGCGCCGCTGCGCAGCTTCGATCCGATGATTGTCGAAACCC
TGGTGGAAGTGATGAACACCGAAGGGCCAAGCCTGCACACCGAATCGGTGCCGAAGGCCATCGTCAAGAACGCCGACGGC
AGCCTGACGCTACAGTTGGAAAACGGCAAAGAATTCATCGTCGACAGCCTGGTGTGGGCGATTGGCCGCGAACCGGCGAC
CGATAACCTGAACCTGGCCGTGACCGGGGTGAAAACCAACGAAAATGGCTATATCGACGTCGATAAATACCAGAACACCA
ACGTAAAAGGCATTTACGCGGTGGGCGACAACACCGGTGCCGTTGAACTGACTCCGGTTGCCGTGGCCGCAGGCCGCCGT
CTGTCCGAGCGTTTGTTTAACAACAAGCCGGAAGAACACCTGGATTACAGCAACATCGCCACCGTGGTGTTCAGCCACCC
GCCGATCGGAACTATCGGCCTGACCGAACCGGAAGCAATCGAGAAATTCGGTGCGGACAGCGTGAAAGTGTATAAATCTT
CATTTACCGCCATGTACAGCGCCGTAACGCAACACCGCCAACCGTGCCGCATGAAGCTGGTGTGCGTGGGTAAAGAAGAG
AAGATTGTTGGCCTGCACGGCATTGGCTTCGGCATGGACGAGATCCTGCAGGGCTTCGCCGTCGCCATCAAGATGGGCGC
CACCAAGAAAGACTTCGACAACACCGTCGCGATCCACCCGACCGCAGCGGAAGAGTTCGTTACCATGCGTTGA

Upstream 100 bases:

>100_bases
ACCCCACCTATCGCAACCATCGACGCAATCTTTGCGACAAACCTGCATCAGGCGTTAAACTCTTACGCTCTTCGATTCAC
ACAATTCATGGAAATCCCAG

Downstream 100 bases:

>100_bases
TTTGCCTGCCCGGCGTGCAATGCCGCTGGGTAAACGGCAACAAAAAGGTCAGGTGCCTCAGGACCCTGACCTTTTTTTAT
ATTGGACAAACACTAAGAAA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTKHYDYLAIGGGSGGIASINRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIAEAIHMYGPDYGFDTTVNAFD
WKKLVANRTAYIDRIHNSYDNVLGKNKVDVIKGFARFIDANTVEVNGEKITADHILIATGGRPSHPDIPGAEYGIDSDGF
FELDAMPKRVAVVGAGYIAVEIAGVMNALGAETHLFVRKHAPLRSFDPMIVETLVEVMNTEGPSLHTESVPKAIVKNADG
SLTLQLENGKEFIVDSLVWAIGREPATDNLNLAVTGVKTNENGYIDVDKYQNTNVKGIYAVGDNTGAVELTPVAVAAGRR
LSERLFNNKPEEHLDYSNIATVVFSHPPIGTIGLTEPEAIEKFGADSVKVYKSSFTAMYSAVTQHRQPCRMKLVCVGKEE
KIVGLHGIGFGMDEILQGFAVAIKMGATKKDFDNTVAIHPTAAEEFVTMR

Sequences:

>Translated_450_residues
MTKHYDYLAIGGGSGGIASINRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIAEAIHMYGPDYGFDTTVNAFD
WKKLVANRTAYIDRIHNSYDNVLGKNKVDVIKGFARFIDANTVEVNGEKITADHILIATGGRPSHPDIPGAEYGIDSDGF
FELDAMPKRVAVVGAGYIAVEIAGVMNALGAETHLFVRKHAPLRSFDPMIVETLVEVMNTEGPSLHTESVPKAIVKNADG
SLTLQLENGKEFIVDSLVWAIGREPATDNLNLAVTGVKTNENGYIDVDKYQNTNVKGIYAVGDNTGAVELTPVAVAAGRR
LSERLFNNKPEEHLDYSNIATVVFSHPPIGTIGLTEPEAIEKFGADSVKVYKSSFTAMYSAVTQHRQPCRMKLVCVGKEE
KIVGLHGIGFGMDEILQGFAVAIKMGATKKDFDNTVAIHPTAAEEFVTMR
>Mature_449_residues
TKHYDYLAIGGGSGGIASINRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIAEAIHMYGPDYGFDTTVNAFDW
KKLVANRTAYIDRIHNSYDNVLGKNKVDVIKGFARFIDANTVEVNGEKITADHILIATGGRPSHPDIPGAEYGIDSDGFF
ELDAMPKRVAVVGAGYIAVEIAGVMNALGAETHLFVRKHAPLRSFDPMIVETLVEVMNTEGPSLHTESVPKAIVKNADGS
LTLQLENGKEFIVDSLVWAIGREPATDNLNLAVTGVKTNENGYIDVDKYQNTNVKGIYAVGDNTGAVELTPVAVAAGRRL
SERLFNNKPEEHLDYSNIATVVFSHPPIGTIGLTEPEAIEKFGADSVKVYKSSFTAMYSAVTQHRQPCRMKLVCVGKEEK
IVGLHGIGFGMDEILQGFAVAIKMGATKKDFDNTVAIHPTAAEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=53.8126361655773, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=38.1856540084388, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI148277065, Length=456, Percent_Identity=36.4035087719298, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI33519430, Length=456, Percent_Identity=36.4035087719298, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI33519428, Length=456, Percent_Identity=36.4035087719298, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI33519426, Length=456, Percent_Identity=36.4035087719298, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=36.8421052631579, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI291045266, Length=439, Percent_Identity=32.8018223234624, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI291045268, Length=439, Percent_Identity=30.2961275626424, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=28.1659388646288, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=85.5555555555556, Blast_Score=792, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=29.490022172949, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI87082354, Length=468, Percent_Identity=27.7777777777778, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=25.6578947368421, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=56.4444444444444, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=56.4444444444444, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=36.2869198312236, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71982272, Length=484, Percent_Identity=33.6776859504132, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=28.2937365010799, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17559934, Length=186, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=51.3918629550321, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=27.7542372881356, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=24.468085106383, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=39.4904458598726, Blast_Score=294, Evalue=9e-80,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=39.4904458598726, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=39.4904458598726, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=37.8435517970402, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=29.2207792207792, Blast_Score=164, Evalue=8e-41,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48664; Mature: 48533

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHYDYLAIGGGSGGIASINRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIA
CCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEHHHCCCEEEEECCCCHHHHHHHHHHH
EAIHMYGPDYGFDTTVNAFDWKKLVANRTAYIDRIHNSYDNVLGKNKVDVIKGFARFIDA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
NTVEVNGEKITADHILIATGGRPSHPDIPGAEYGIDSDGFFELDAMPKRVAVVGAGYIAV
CEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHEE
EIAGVMNALGAETHLFVRKHAPLRSFDPMIVETLVEVMNTEGPSLHTESVPKAIVKNADG
HHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC
SLTLQLENGKEFIVDSLVWAIGREPATDNLNLAVTGVKTNENGYIDVDKYQNTNVKGIYA
EEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCCCEEEE
VGDNTGAVELTPVAVAAGRRLSERLFNNKPEEHLDYSNIATVVFSHPPIGTIGLTEPEAI
ECCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECCCCCCCCCCCCHHHH
EKFGADSVKVYKSSFTAMYSAVTQHRQPCRMKLVCVGKEEKIVGLHGIGFGMDEILQGFA
HHHCCCCEEHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHE
VAIKMGATKKDFDNTVAIHPTAAEEFVTMR
EEEEECCCCCCCCCEEEECCCCHHHHEECC
>Mature Secondary Structure 
TKHYDYLAIGGGSGGIASINRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIA
CCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEHHHCCCEEEEECCCCHHHHHHHHHHH
EAIHMYGPDYGFDTTVNAFDWKKLVANRTAYIDRIHNSYDNVLGKNKVDVIKGFARFIDA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
NTVEVNGEKITADHILIATGGRPSHPDIPGAEYGIDSDGFFELDAMPKRVAVVGAGYIAV
CEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHEE
EIAGVMNALGAETHLFVRKHAPLRSFDPMIVETLVEVMNTEGPSLHTESVPKAIVKNADG
HHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC
SLTLQLENGKEFIVDSLVWAIGREPATDNLNLAVTGVKTNENGYIDVDKYQNTNVKGIYA
EEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCCCEEEE
VGDNTGAVELTPVAVAAGRRLSERLFNNKPEEHLDYSNIATVVFSHPPIGTIGLTEPEAI
ECCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECCCCCCCCCCCCHHHH
EKFGADSVKVYKSSFTAMYSAVTQHRQPCRMKLVCVGKEEKIVGLHGIGFGMDEILQGFA
HHHCCCCEEHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHE
VAIKMGATKKDFDNTVAIHPTAAEEFVTMR
EEEEECCCCCCCCCEEEECCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]