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The map label for this gene is glpG

Identifier: 157372871

GI number: 157372871

Start: 5120740

End: 5121576

Strand: Direct

Name: glpG

Synonym: Spro_4639

Alternate gene names: 157372871

Gene position: 5120740-5121576 (Clockwise)

Preceding gene: 157372870

Following gene: 157372872

Centisome position: 93.98

GC content: 58.9

Gene sequence:

>837_bases
ATGGTTAGAGTAATCGCCGTATCCAATCCCCGCCTGGCGCAGGCCTTTGTCGACTACATGACGACACAGGGCATTGAGCT
TAGGGTGCACAATACCGGCGAGGCGGCGGAAATCTGGCTGGCAGACGACAGCCATCTGGAGCAGGTGCAGCACGAACTGC
AGCAGTTTCTGATCGACCCGCTTAACAGTCGCTATCGCGCCGCCAGTTGGCAGGCCGGCAATACCGATGCCGACCTGCAC
TATCAGGGCTTTTCCTATCTGCAAACCCTGCGCAGCAAGGCCGGGCCGCTGACGCTCGGCGTGATGGCTCTGTGCATTGT
GGTCTATATCCTGATGCAGATATTGGGCGATGATACCCTGATGTACTGGCTCTCCTGGCCGCAAGACAGCAGCCAGTACC
TGCAGCTGTGGCGCTGGGTCAGCCACGCTTTCCTCCATTTCTCACTGCTGCACATCACCTTTAACCTGCTGTGGTGGTGG
TATCTCGGCGGCCCGCTGGAAAAACGCCTCGGCAGCGGCAAACTGTTCGTGCTGGCAGTGGTCTCGGCCTTCTTCAGCGG
CTGGGCGCAGTCGCTGTTTAGCGGTGCGTTGTTCGGCGGCCTGTCCGGCGTGGTCTACGCTCTGATGGGTTACTGCTGGC
TCAGCGGCGAGCGAGCACCGGAACGCGGTCTGATGCTGCCGCGCGGCCTGATGGTGTTTTCGGTCCTGTGGCTGGTGGCC
GGATATTTCGATATTTTAGGAATGTCGATCGCTAACGCGGCACACGTAGCCGGTTTAGTGTTAGGGTTATTGATGGCATT
TTGGGACACGCGTCATCGCGCGCACAACGAACAATAA

Upstream 100 bases:

>100_bases
CGCAGATCCTTTGCCTGCGCTCAGGATTTCGACGCTATAATCGGCCGTCAACGCCATCGGGTCACCGGCGGCTAAAATCA
TTCACTTAGACGGAAGAGCA

Downstream 100 bases:

>100_bases
CAGCCAGGTACAAGCCAGGCGTTTTAGGGGATTACCGTGAAGCAAACACAGCGTCATGACGCTATTATCGAGCTGGTGCG
CCTGCAGGGTTATGTCAGTA

Product: intramembrane serine protease GlpG

Products: NA

Alternate protein names: Intramembrane serine protease

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MVRVIAVSNPRLAQAFVDYMTTQGIELRVHNTGEAAEIWLADDSHLEQVQHELQQFLIDPLNSRYRAASWQAGNTDADLH
YQGFSYLQTLRSKAGPLTLGVMALCIVVYILMQILGDDTLMYWLSWPQDSSQYLQLWRWVSHAFLHFSLLHITFNLLWWW
YLGGPLEKRLGSGKLFVLAVVSAFFSGWAQSLFSGALFGGLSGVVYALMGYCWLSGERAPERGLMLPRGLMVFSVLWLVA
GYFDILGMSIANAAHVAGLVLGLLMAFWDTRHRAHNEQ

Sequences:

>Translated_278_residues
MVRVIAVSNPRLAQAFVDYMTTQGIELRVHNTGEAAEIWLADDSHLEQVQHELQQFLIDPLNSRYRAASWQAGNTDADLH
YQGFSYLQTLRSKAGPLTLGVMALCIVVYILMQILGDDTLMYWLSWPQDSSQYLQLWRWVSHAFLHFSLLHITFNLLWWW
YLGGPLEKRLGSGKLFVLAVVSAFFSGWAQSLFSGALFGGLSGVVYALMGYCWLSGERAPERGLMLPRGLMVFSVLWLVA
GYFDILGMSIANAAHVAGLVLGLLMAFWDTRHRAHNEQ
>Mature_278_residues
MVRVIAVSNPRLAQAFVDYMTTQGIELRVHNTGEAAEIWLADDSHLEQVQHELQQFLIDPLNSRYRAASWQAGNTDADLH
YQGFSYLQTLRSKAGPLTLGVMALCIVVYILMQILGDDTLMYWLSWPQDSSQYLQLWRWVSHAFLHFSLLHITFNLLWWW
YLGGPLEKRLGSGKLFVLAVVSAFFSGWAQSLFSGALFGGLSGVVYALMGYCWLSGERAPERGLMLPRGLMVFSVLWLVA
GYFDILGMSIANAAHVAGLVLGLLMAFWDTRHRAHNEQ

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family

Homologues:

Organism=Escherichia coli, GI48994938, Length=270, Percent_Identity=55.9259259259259, Blast_Score=325, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLPG_SERP5 (A8GKU2)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480860.1
- ProteinModelPortal:   A8GKU2
- SMR:   A8GKU2
- STRING:   A8GKU2
- MEROPS:   S54.016
- GeneID:   5603059
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4639
- eggNOG:   COG0705
- HOGENOM:   HBG495087
- OMA:   WYLGGKI
- ProtClustDB:   PRK10907
- BioCyc:   SPRO399741:SPRO_4639-MONOMER
- HAMAP:   MF_01594
- InterPro:   IPR022732
- InterPro:   IPR002610
- InterPro:   IPR022764
- PANTHER:   PTHR22936

Pfam domain/function: PF12122 DUF3582; PF01694 Rhomboid

EC number: =3.4.21.105

Molecular weight: Translated: 31390; Mature: 31390

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: ACT_SITE 202-202 ACT_SITE 255-255

Signals:

None

Transmembrane regions:

HASH(0x1217b224)-; HASH(0x1232e548)-; HASH(0x11e162dc)-; HASH(0x11b1915c)-; HASH(0x11a94c64)-; HASH(0x12330e30)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVIAVSNPRLAQAFVDYMTTQGIELRVHNTGEAAEIWLADDSHLEQVQHELQQFLIDP
CEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHH
LNSRYRAASWQAGNTDADLHYQGFSYLQTLRSKAGPLTLGVMALCIVVYILMQILGDDTL
HCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCE
MYWLSWPQDSSQYLQLWRWVSHAFLHFSLLHITFNLLWWWYLGGPLEKRLGSGKLFVLAV
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHH
VSAFFSGWAQSLFSGALFGGLSGVVYALMGYCWLSGERAPERGLMLPRGLMVFSVLWLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
GYFDILGMSIANAAHVAGLVLGLLMAFWDTRHRAHNEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MVRVIAVSNPRLAQAFVDYMTTQGIELRVHNTGEAAEIWLADDSHLEQVQHELQQFLIDP
CEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHH
LNSRYRAASWQAGNTDADLHYQGFSYLQTLRSKAGPLTLGVMALCIVVYILMQILGDDTL
HCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCE
MYWLSWPQDSSQYLQLWRWVSHAFLHFSLLHITFNLLWWWYLGGPLEKRLGSGKLFVLAV
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHH
VSAFFSGWAQSLFSGALFGGLSGVVYALMGYCWLSGERAPERGLMLPRGLMVFSVLWLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
GYFDILGMSIANAAHVAGLVLGLLMAFWDTRHRAHNEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA