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The map label for this gene is glpR [H]

Identifier: 157372872

GI number: 157372872

Start: 5121613

End: 5122371

Strand: Direct

Name: glpR [H]

Synonym: Spro_4640

Alternate gene names: 157372872

Gene position: 5121613-5122371 (Clockwise)

Preceding gene: 157372871

Following gene: 157372874

Centisome position: 93.99

GC content: 55.2

Gene sequence:

>759_bases
GTGAAGCAAACACAGCGTCATGACGCTATTATCGAGCTGGTGCGCCTGCAGGGTTATGTCAGTACCGAAGAGCTGGTCGA
ACATTTTGACGTTAGCCCGCAAACGATTCGTCGTGATTTGAATGACCTGGCCGATCAGAACAAAATCCAACGCCACCACG
GTGGGGCAGCCTTGCCTTCCAGTTCGGTCAATGCCGCCTACAACGATCGCAAAGTGATGTGGTCGGAACAGAAAGCGCGT
ATAGCTCAACGCGTCGCCAGCCAGATCCCGGACGGCGCCACGCTGTTTATCGACATCGGCACCACCCCGGAAGCGGTCGC
CCATGCGCTGATGAATCACAAGAACCTGCGCGTGGTGACCAATAACCTGAACGTCGCCACTCTGCTGACCGCCAAGGAAG
ATTTCCGTCTGATCCTGGCCGGTGGCGAGGTACGTACCCGCGACGGCGGTATCATGGGTGAGGCCACGCTGGACTTTATC
TCCCAGTTCCGTCTCGATTACGGCATTCTGGGTATCAGCGGCATCGATATGGACGGCTCGCTGCTTGAATTCGACTATCA
CGAAGTGCGCACCAAACGCGCAATTATCGAAAATTCACGCTGCGTGATGTTGGTCACCGACCATTCCAAATTCGGCCGCA
ACGCGATGGTTAACCTCGGCAATATGAGCCTGATCGACTACCTGTTTACCGATCAACTGCCGCCGCCAAGCGTGATGAAA
ATCATCGAGCAGTACGACGTACAGCTGGAGTTGTGTTAA

Upstream 100 bases:

>100_bases
TTTAGTGTTAGGGTTATTGATGGCATTTTGGGACACGCGTCATCGCGCGCACAACGAACAATAACAGCCAGGTACAAGCC
AGGCGTTTTAGGGGATTACC

Downstream 100 bases:

>100_bases
GCCCTTCTCTCGCATCTTCTCCTTTTGGAGAAGGTGCTAGGGAGCATTTTTCCTGCTTAAGCGTTTTTCAAGCTGCTCAA
GTTGTTCCAGTTCAATTCGG

Product: DNA-binding transcriptional repressor GlpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MKQTQRHDAIIELVRLQGYVSTEELVEHFDVSPQTIRRDLNDLADQNKIQRHHGGAALPSSSVNAAYNDRKVMWSEQKAR
IAQRVASQIPDGATLFIDIGTTPEAVAHALMNHKNLRVVTNNLNVATLLTAKEDFRLILAGGEVRTRDGGIMGEATLDFI
SQFRLDYGILGISGIDMDGSLLEFDYHEVRTKRAIIENSRCVMLVTDHSKFGRNAMVNLGNMSLIDYLFTDQLPPPSVMK
IIEQYDVQLELC

Sequences:

>Translated_252_residues
MKQTQRHDAIIELVRLQGYVSTEELVEHFDVSPQTIRRDLNDLADQNKIQRHHGGAALPSSSVNAAYNDRKVMWSEQKAR
IAQRVASQIPDGATLFIDIGTTPEAVAHALMNHKNLRVVTNNLNVATLLTAKEDFRLILAGGEVRTRDGGIMGEATLDFI
SQFRLDYGILGISGIDMDGSLLEFDYHEVRTKRAIIENSRCVMLVTDHSKFGRNAMVNLGNMSLIDYLFTDQLPPPSVMK
IIEQYDVQLELC
>Mature_252_residues
MKQTQRHDAIIELVRLQGYVSTEELVEHFDVSPQTIRRDLNDLADQNKIQRHHGGAALPSSSVNAAYNDRKVMWSEQKAR
IAQRVASQIPDGATLFIDIGTTPEAVAHALMNHKNLRVVTNNLNVATLLTAKEDFRLILAGGEVRTRDGGIMGEATLDFI
SQFRLDYGILGISGIDMDGSLLEFDYHEVRTKRAIIENSRCVMLVTDHSKFGRNAMVNLGNMSLIDYLFTDQLPPPSVMK
IIEQYDVQLELC

Specific function: Repressor of the glycerol-3-phosphate regulon [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=252, Percent_Identity=76.984126984127, Blast_Score=413, Evalue=1e-117,
Organism=Escherichia coli, GI87082344, Length=247, Percent_Identity=42.1052631578947, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1789059, Length=251, Percent_Identity=29.4820717131474, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788069, Length=251, Percent_Identity=27.8884462151394, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1789519, Length=251, Percent_Identity=27.4900398406374, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI226510968, Length=250, Percent_Identity=30, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789170, Length=230, Percent_Identity=27.3913043478261, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790753, Length=253, Percent_Identity=24.5059288537549, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787063, Length=224, Percent_Identity=27.2321428571429, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1787540, Length=228, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1790635, Length=262, Percent_Identity=22.9007633587786, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28252; Mature: 28252

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTQRHDAIIELVRLQGYVSTEELVEHFDVSPQTIRRDLNDLADQNKIQRHHGGAALPS
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SSVNAAYNDRKVMWSEQKARIAQRVASQIPDGATLFIDIGTTPEAVAHALMNHKNLRVVT
CCCCCCCCCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEE
NNLNVATLLTAKEDFRLILAGGEVRTRDGGIMGEATLDFISQFRLDYGILGISGIDMDGS
CCCCEEEEEEECCCCEEEEECCEEEECCCCEECHHHHHHHHHHHHHHCEEEEECCCCCCC
LLEFDYHEVRTKRAIIENSRCVMLVTDHSKFGRNAMVNLGNMSLIDYLFTDQLPPPSVMK
EEECHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHCCCCCHHHHH
IIEQYDVQLELC
HHHHHCCEEEEC
>Mature Secondary Structure
MKQTQRHDAIIELVRLQGYVSTEELVEHFDVSPQTIRRDLNDLADQNKIQRHHGGAALPS
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SSVNAAYNDRKVMWSEQKARIAQRVASQIPDGATLFIDIGTTPEAVAHALMNHKNLRVVT
CCCCCCCCCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEE
NNLNVATLLTAKEDFRLILAGGEVRTRDGGIMGEATLDFISQFRLDYGILGISGIDMDGS
CCCCEEEEEEECCCCEEEEECCEEEECCCCEECHHHHHHHHHHHHHHCEEEEECCCCCCC
LLEFDYHEVRTKRAIIENSRCVMLVTDHSKFGRNAMVNLGNMSLIDYLFTDQLPPPSVMK
EEECHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHCCCCCHHHHH
IIEQYDVQLELC
HHHHHCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8955387; 3045764; 9278503 [H]