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The map label for this gene is gcp

Identifier: 157372530

GI number: 157372530

Start: 4763414

End: 4764427

Strand: Reverse

Name: gcp

Synonym: Spro_4297

Alternate gene names: 157372530

Gene position: 4764427-4763414 (Counterclockwise)

Preceding gene: 157372534

Following gene: 157372528

Centisome position: 87.44

GC content: 59.76

Gene sequence:

>1014_bases
ATGCGAGTACTGGGTATAGAAACCTCCTGCGATGAAACCGGAATTGCAGTGTATGACGATCAGGCCGGTTTATTAGCGAA
TCAATTGTACAGCCAGGTGAAGCTGCACGCCGACTACGGCGGTGTGGTGCCGGAACTGGCTTCCCGCGATCATGTGCGTA
AAACCGTGCCCTTGATTCAGGCGGCATTGAAGGAAGCGAACCTGACCGCGGCCGATATCGACGGCGTTGCCTATACTGCC
GGGCCGGGCCTGGTGGGGGCGCTGCTGGTCGGCGCGACCATTGGTCGTGCGCTGGCGTTTGCCTGGGGCGTGCCGGCAGT
ACCGGTGCATCACATGGAAGGCCACTTGCTGGCACCGATGCTGGAAGACAATCCACCGGCGTTCCCGTTTGTCGCGCTGC
TGGTTTCCGGCGGCCATACCCAGTTGATCAGCGTGACCGGCATTGGTCAATACCAACTGCTGGGCGAATCGGTCGACGAT
GCGGCGGGTGAAGCCTTCGACAAAACGGCCAAGCTGTTGGGGCTGGACTATCCCGGCGGGCCAATGCTGTCGAAAATGGC
GCAGCAGGGTGCCGCAGGCCGTTTCACCTTCCCACGGCCAATGACCGATCGGCCGGGGCTGGATTTCAGTTTCTCCGGGT
TGAAGACCTTTGCCGCCAACACCATTCGTTCCAACGGTAATGACGATCAGACGCGTGCGGACATTGCTCGGGCGTTTGAA
GATGCGGTAGTGGATACGTTGGCGATCAAATGCAAACGTGCGCTGGAGCAAACCGGTTTCAAACGGCTGGTTATGGCCGG
CGGCGTCAGTGCCAACCGCACGCTACGCACCAAAATGGCGGAAATGCTGCACAAACGCGGCGGTGAGGTGTTCTACGCCC
GTCCGGAATTCTGCACGGATAACGGCGCAATGATCGCTTATGCGGGTCTGGTACGGTTGCAGAGCGGTGCCAATCCGGAA
CTGAGCGTTTCGGTGCGACCGCGTTGGCCGCTGGCTGAATTGTCTGCGGTATAA

Upstream 100 bases:

>100_bases
ATCAACATAGCCCAGAAGGGCCGACAAGATGCGCCGCACTGGCGGTAAACCGGCCTGTTTGTGCTAAACTGGCGGCCGCA
CGTGAATGATGGGAAATGTA

Downstream 100 bases:

>100_bases
ATAGTCGAAGGCCGGAGAGCTCCGGCCTTTTTGATTACTCTTCTTTTTTTTCTTCCTGCTCTGCCGCGTCGTTTTTCTTC
TTGCGGAAGACACCCCAGAT

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MRVLGIETSCDETGIAVYDDQAGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQAALKEANLTAADIDGVAYTA
GPGLVGALLVGATIGRALAFAWGVPAVPVHHMEGHLLAPMLEDNPPAFPFVALLVSGGHTQLISVTGIGQYQLLGESVDD
AAGEAFDKTAKLLGLDYPGGPMLSKMAQQGAAGRFTFPRPMTDRPGLDFSFSGLKTFAANTIRSNGNDDQTRADIARAFE
DAVVDTLAIKCKRALEQTGFKRLVMAGGVSANRTLRTKMAEMLHKRGGEVFYARPEFCTDNGAMIAYAGLVRLQSGANPE
LSVSVRPRWPLAELSAV

Sequences:

>Translated_337_residues
MRVLGIETSCDETGIAVYDDQAGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQAALKEANLTAADIDGVAYTA
GPGLVGALLVGATIGRALAFAWGVPAVPVHHMEGHLLAPMLEDNPPAFPFVALLVSGGHTQLISVTGIGQYQLLGESVDD
AAGEAFDKTAKLLGLDYPGGPMLSKMAQQGAAGRFTFPRPMTDRPGLDFSFSGLKTFAANTIRSNGNDDQTRADIARAFE
DAVVDTLAIKCKRALEQTGFKRLVMAGGVSANRTLRTKMAEMLHKRGGEVFYARPEFCTDNGAMIAYAGLVRLQSGANPE
LSVSVRPRWPLAELSAV
>Mature_337_residues
MRVLGIETSCDETGIAVYDDQAGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQAALKEANLTAADIDGVAYTA
GPGLVGALLVGATIGRALAFAWGVPAVPVHHMEGHLLAPMLEDNPPAFPFVALLVSGGHTQLISVTGIGQYQLLGESVDD
AAGEAFDKTAKLLGLDYPGGPMLSKMAQQGAAGRFTFPRPMTDRPGLDFSFSGLKTFAANTIRSNGNDDQTRADIARAFE
DAVVDTLAIKCKRALEQTGFKRLVMAGGVSANRTLRTKMAEMLHKRGGEVFYARPEFCTDNGAMIAYAGLVRLQSGANPE
LSVSVRPRWPLAELSAV

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=337, Percent_Identity=33.8278931750742, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI8923380, Length=323, Percent_Identity=33.7461300309598, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1789445, Length=336, Percent_Identity=89.2857142857143, Blast_Score=624, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17557464, Length=329, Percent_Identity=30.6990881458967, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71995670, Length=329, Percent_Identity=34.6504559270517, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320099, Length=375, Percent_Identity=32.5333333333333, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322891, Length=348, Percent_Identity=28.448275862069, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI20129063, Length=338, Percent_Identity=34.3195266272189, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21357207, Length=329, Percent_Identity=30.0911854103343, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_SERP5 (A8GJV1)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480519.1
- ProteinModelPortal:   A8GJV1
- SMR:   A8GJV1
- STRING:   A8GJV1
- MEROPS:   M22.001
- GeneID:   5604402
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4297
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   SPRO399741:SPRO_4297-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 35750; Mature: 35750

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLGIETSCDETGIAVYDDQAGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQ
CEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHEEECCCCCCCHHHHCHHHHHHHHHHHH
AALKEANLTAADIDGVAYTAGPGLVGALLVGATIGRALAFAWGVPAVPVHHMEGHLLAPM
HHHHHCCCCEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCH
LEDNPPAFPFVALLVSGGHTQLISVTGIGQYQLLGESVDDAAGEAFDKTAKLLGLDYPGG
HCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHECCCCHHHHHHHHHHHHHHHHCCCCCCC
PMLSKMAQQGAAGRFTFPRPMTDRPGLDFSFSGLKTFAANTIRSNGNDDQTRADIARAFE
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
DAVVDTLAIKCKRALEQTGFKRLVMAGGVSANRTLRTKMAEMLHKRGGEVFYARPEFCTD
HHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEECC
NGAMIAYAGLVRLQSGANPELSVSVRPRWPLAELSAV
CCCEEEHHHHHHHCCCCCCCEEEEECCCCCHHHHCCC
>Mature Secondary Structure
MRVLGIETSCDETGIAVYDDQAGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQ
CEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHEEECCCCCCCHHHHCHHHHHHHHHHHH
AALKEANLTAADIDGVAYTAGPGLVGALLVGATIGRALAFAWGVPAVPVHHMEGHLLAPM
HHHHHCCCCEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCH
LEDNPPAFPFVALLVSGGHTQLISVTGIGQYQLLGESVDDAAGEAFDKTAKLLGLDYPGG
HCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHECCCCHHHHHHHHHHHHHHHHCCCCCCC
PMLSKMAQQGAAGRFTFPRPMTDRPGLDFSFSGLKTFAANTIRSNGNDDQTRADIARAFE
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
DAVVDTLAIKCKRALEQTGFKRLVMAGGVSANRTLRTKMAEMLHKRGGEVFYARPEFCTD
HHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEECC
NGAMIAYAGLVRLQSGANPELSVSVRPRWPLAELSAV
CCCEEEHHHHHHHCCCCCCCEEEEECCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA