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The map label for this gene is mug

Identifier: 157372534

GI number: 157372534

Start: 4769345

End: 4769833

Strand: Reverse

Name: mug

Synonym: Spro_4301

Alternate gene names: 157372534

Gene position: 4769833-4769345 (Counterclockwise)

Preceding gene: 157372535

Following gene: 157372530

Centisome position: 87.54

GC content: 59.1

Gene sequence:

>489_bases
ATGGAACTCCTGGCACCCAACCTGCGGGTCGTGTTTTGCGGCATCAACCCTGGCCTGTCCTCGGCCCATCAAGGCTACCC
CTTTGCTAACGGCAGTAACCGCTTCTGGAAGGTAGTGCATCAGGCCGGTTTTACCGATACTCAGTTAGCGCCTGAGCAGT
GGCAACAGCTGCAGGATACCGGTTGTGGCATCACTGCGCTGGTGGCGCGGCCCACGGTGGCGGCCAGTGAGGTAACGCGT
GACGAATTGCTCAGCGGCGGTGAGGCGTTAAAGGAAAAGATCCTGCGTTACCAGCCGCGTGCGCTGGCGATTTTGGGCAA
GCAGGCGTTCAGCAGTGCCTTTGGGGTGAAAAATGCGGCCTGGGGCCGTCAGGAGATGACGATCGGCAAAACGGAGGTTT
GGGTATTGCCTAACCCCAGCGGATTGAACCGTGCCACGCTGGAGCAGCTTACGGAGAGCTACCGCGAGTTGTTCCTGGCT
CTGAAATAA

Upstream 100 bases:

>100_bases
CCATCTGTATGTTGCTTTTATGCGCAGTTCTAGCCTGTTGTAATTGCTGGCGGATTTTGCGATAACCGCTGTAAATCCCT
TTAATGGACTCCCGAACCTT

Downstream 100 bases:

>100_bases
TTTTTATTGCGGGCATGAGATCGATAATAAGGCTGTGGGGACTGTCAAAGAGCTGCCCCGGCTTTTGCCGCGAGCAGCTT
ATACTGACTTAATTCAAACC

Product: G/U mismatch-specific DNA glycosylase

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MELLAPNLRVVFCGINPGLSSAHQGYPFANGSNRFWKVVHQAGFTDTQLAPEQWQQLQDTGCGITALVARPTVAASEVTR
DELLSGGEALKEKILRYQPRALAILGKQAFSSAFGVKNAAWGRQEMTIGKTEVWVLPNPSGLNRATLEQLTESYRELFLA
LK

Sequences:

>Translated_162_residues
MELLAPNLRVVFCGINPGLSSAHQGYPFANGSNRFWKVVHQAGFTDTQLAPEQWQQLQDTGCGITALVARPTVAASEVTR
DELLSGGEALKEKILRYQPRALAILGKQAFSSAFGVKNAAWGRQEMTIGKTEVWVLPNPSGLNRATLEQLTESYRELFLA
LK
>Mature_162_residues
MELLAPNLRVVFCGINPGLSSAHQGYPFANGSNRFWKVVHQAGFTDTQLAPEQWQQLQDTGCGITALVARPTVAASEVTR
DELLSGGEALKEKILRYQPRALAILGKQAFSSAFGVKNAAWGRQEMTIGKTEVWVLPNPSGLNRATLEQLTESYRELFLA
LK

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI59853162, Length=148, Percent_Identity=35.1351351351351, Blast_Score=81, Evalue=4e-16,
Organism=Escherichia coli, GI1789449, Length=160, Percent_Identity=63.125, Blast_Score=215, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21356805, Length=140, Percent_Identity=36.4285714285714, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUG_SERP5 (A8GJV5)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480523.1
- ProteinModelPortal:   A8GJV5
- SMR:   A8GJV5
- STRING:   A8GJV5
- GeneID:   5604409
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4301
- eggNOG:   COG3663
- HOGENOM:   HBG424886
- OMA:   FARPGNR
- ProtClustDB:   PRK10201
- BioCyc:   SPRO399741:SPRO_4301-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01956
- InterPro:   IPR015637
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR12159

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.28

Molecular weight: Translated: 17773; Mature: 17773

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLAPNLRVVFCGINPGLSSAHQGYPFANGSNRFWKVVHQAGFTDTQLAPEQWQQLQDT
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHC
GCGITALVARPTVAASEVTRDELLSGGEALKEKILRYQPRALAILGKQAFSSAFGVKNAA
CCCEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
WGRQEMTIGKTEVWVLPNPSGLNRATLEQLTESYRELFLALK
CCCCCEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELLAPNLRVVFCGINPGLSSAHQGYPFANGSNRFWKVVHQAGFTDTQLAPEQWQQLQDT
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHC
GCGITALVARPTVAASEVTRDELLSGGEALKEKILRYQPRALAILGKQAFSSAFGVKNAA
CCCEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
WGRQEMTIGKTEVWVLPNPSGLNRATLEQLTESYRELFLALK
CCCCCEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA