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The map label for this gene is ribB

Identifier: 157372519

GI number: 157372519

Start: 4750636

End: 4751289

Strand: Reverse

Name: ribB

Synonym: Spro_4286

Alternate gene names: 157372519

Gene position: 4751289-4750636 (Counterclockwise)

Preceding gene: 157372521

Following gene: 157372517

Centisome position: 87.2

GC content: 57.49

Gene sequence:

>654_bases
ATGAATCAGACCCTACTTTCAGATTTCGGCACGCCGGTAGAACGCGTAGAACGCGCTCTTGAAGCATTGCGCAATGGGCG
CGGTGTGATGGTGCTCGATGATGAAAATCGTGAAAACGAAGGTGATATGATCTTCGCCGCAGAAACCATGACCGTTGAGC
AGATGGCGCTGACCATTCGCCACGGTAGCGGTATTGTGTGCCTGTGTCTCACCGAAGAACGCCGTCAGCAGCTTGAACTG
CCGATGATGGTGACCAACAACTCCAGCCAGTTCCAGACCGCCTTCACCGTGACTATCGAAGCGGCGCAGGGTGTGACGAC
CGGTGTTTCCGCGTCCGATCGCCTGACCACCATTCGCGCGGCGGTAGCCGATAACGCCAAGCCGAGCGATCTGAATCGTC
CTGGCCACGTGTTCCCACTGCGTGCGCAGCCGGGTGGCGTCCTGAGCCGTCGTGGCCATACCGAAGCGACTATCGATTTG
GTATCGATGGCCGGTTTCAAACCTGCCGGCGTGCTGTGTGAACTGACCAACGATGACGGCAGCATGGCGCATGCGCCAGA
AGTTATCCTGTTCGCCAAACAGCATGATATGACCGTACTGACCATCGAAGATCTGGTGGCCTACCGCCAGGCTCACGAAC
AGAAAGCCAGCTGA

Upstream 100 bases:

>100_bases
GGTTTGCGCCCGCTTGCGTTATTTTTTTAGCTATTGCTAGCTACTCCTCAAGATCGCCCTGGTTCTGGTAATCCATAATT
TTCTAATGAGGTTTTTTACC

Downstream 100 bases:

>100_bases
TATCGGACTGATTTTCTAAATATAAAAAAGCCGCGAATGCGGCTTTTTTTGGCTTAAAAGGTTTAACCGATCCCGCCGCT
TTGCAATAACGTCAGGCTGA

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: DHBP synthase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MNQTLLSDFGTPVERVERALEALRNGRGVMVLDDENRENEGDMIFAAETMTVEQMALTIRHGSGIVCLCLTEERRQQLEL
PMMVTNNSSQFQTAFTVTIEAAQGVTTGVSASDRLTTIRAAVADNAKPSDLNRPGHVFPLRAQPGGVLSRRGHTEATIDL
VSMAGFKPAGVLCELTNDDGSMAHAPEVILFAKQHDMTVLTIEDLVAYRQAHEQKAS

Sequences:

>Translated_217_residues
MNQTLLSDFGTPVERVERALEALRNGRGVMVLDDENRENEGDMIFAAETMTVEQMALTIRHGSGIVCLCLTEERRQQLEL
PMMVTNNSSQFQTAFTVTIEAAQGVTTGVSASDRLTTIRAAVADNAKPSDLNRPGHVFPLRAQPGGVLSRRGHTEATIDL
VSMAGFKPAGVLCELTNDDGSMAHAPEVILFAKQHDMTVLTIEDLVAYRQAHEQKAS
>Mature_217_residues
MNQTLLSDFGTPVERVERALEALRNGRGVMVLDDENRENEGDMIFAAETMTVEQMALTIRHGSGIVCLCLTEERRQQLEL
PMMVTNNSSQFQTAFTVTIEAAQGVTTGVSASDRLTTIRAAVADNAKPSDLNRPGHVFPLRAQPGGVLSRRGHTEATIDL
VSMAGFKPAGVLCELTNDDGSMAHAPEVILFAKQHDMTVLTIEDLVAYRQAHEQKAS

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHBP synthase family

Homologues:

Organism=Escherichia coli, GI1789420, Length=217, Percent_Identity=81.5668202764977, Blast_Score=374, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6320695, Length=201, Percent_Identity=43.2835820895522, Blast_Score=178, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBB_SERP5 (A8GJU0)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480508.1
- ProteinModelPortal:   A8GJU0
- SMR:   A8GJU0
- STRING:   A8GJU0
- GeneID:   5604728
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4286
- eggNOG:   COG0108
- HOGENOM:   HBG735778
- OMA:   RGHTEAT
- ProtClustDB:   PRK03353
- BioCyc:   SPRO399741:SPRO_4286-MONOMER
- HAMAP:   MF_00180
- InterPro:   IPR017945
- InterPro:   IPR000422
- Gene3D:   G3DSA:3.90.870.10
- TIGRFAMs:   TIGR00506

Pfam domain/function: PF00926 DHBP_synthase; SSF55821 DHBP_synth_RibB-like_a/b_dom

EC number: =4.1.99.12

Molecular weight: Translated: 23623; Mature: 23623

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: BINDING 42-42 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTLLSDFGTPVERVERALEALRNGRGVMVLDDENRENEGDMIFAAETMTVEQMALTIR
CCCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEHHEEEEEEEEEE
HGSGIVCLCLTEERRQQLELPMMVTNNSSQFQTAFTVTIEAAQGVTTGVSASDRLTTIRA
CCCCEEEEEECHHHHHHCCCCEEEECCCCCEEEEEEEEEECCCCEECCCCCCCHHHEEEE
AVADNAKPSDLNRPGHVFPLRAQPGGVLSRRGHTEATIDLVSMAGFKPAGVLCELTNDDG
HHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHEEEEEHHCCCCCCCEEEEEECCCC
SMAHAPEVILFAKQHDMTVLTIEDLVAYRQAHEQKAS
CCCCCCEEEEEEECCCEEEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQTLLSDFGTPVERVERALEALRNGRGVMVLDDENRENEGDMIFAAETMTVEQMALTIR
CCCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEHHEEEEEEEEEE
HGSGIVCLCLTEERRQQLELPMMVTNNSSQFQTAFTVTIEAAQGVTTGVSASDRLTTIRA
CCCCEEEEEECHHHHHHCCCCEEEECCCCCEEEEEEEEEECCCCEECCCCCCCHHHEEEE
AVADNAKPSDLNRPGHVFPLRAQPGGVLSRRGHTEATIDLVSMAGFKPAGVLCELTNDDG
HHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHEEEEEHHCCCCCCCEEEEEECCCC
SMAHAPEVILFAKQHDMTVLTIEDLVAYRQAHEQKAS
CCCCCCEEEEEEECCCEEEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA