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The map label for this gene is epd [H]

Identifier: 157372180

GI number: 157372180

Start: 4370879

End: 4371895

Strand: Reverse

Name: epd [H]

Synonym: Spro_3946

Alternate gene names: 157372180

Gene position: 4371895-4370879 (Counterclockwise)

Preceding gene: 157372181

Following gene: 157372179

Centisome position: 80.24

GC content: 56.93

Gene sequence:

>1017_bases
ATGACAATCCGCATAGCGATAAACGGCTTTGGCCGCATTGGCCGCAGCGTTTTACGCGCACTGTATGAATCGGGACGAAG
AGCGGAGATTTCCGTGGTGGCGATCAACGAATTGGCAAACGCCGAGGGGATGGCCCACCTGCTGAAATACGACTCCAGCC
ATGGCCGCTTTGCCTGGGATGTTCGCCAGGAATGCGACATGCTGACCGTCGGGGACGACACCATTCGCTTGCTGCATCAG
CCGGCGGTGGAACAGCTTCCCTGGGGAGAGTTGGGTGTTGACGTGGTACTGGACTGCAGCGGTGTGTACGGCAGCCGGGC
AGATGGCGAAGCCCATCTGGCGGCGGGGGCGAAAAAAGTGTTGTTCGCCCACCCAGGTGGTAACGATCTGGACGCCACCA
TCGTGTTCGGCGTCAACCATCAGACGCTGCTGGCAGAACACCGCATTGTTTCCAATGCGTCATGCACCACCAACTGCATT
ATTCCGGTGATTAAGCTGCTGGACGATGCCTACAGCATCGAATCGGGCACCCTGACCACTATTCACTCTTCGATGAACGA
TCAGCCGGTGATAGACGCCTATCATCAGGATTTGCGGCGTACCCGTGCGGCGAGCCAGTCGATTATTCCGGTCGACACCA
AGCTGGCCGCGGGCATCACCCGTATTTTTCCGCAGTTTTGCGATCGTTTCGAAGCGATTTCGGTGCGCGTGCCGACCATC
AACGTGACGGCCATCGATCTCAGCGTCAGCGTCAGTTCGGCGGTGAAGGTGACAGAGGTCAACCAGCTGCTGCAAATGGC
CGCACGGGGATCATTTCGTGGTATAGTTGACTATACGGAACTACCATTAGTCTCGATCGATTTTAACCATGACCCGCATA
GCGCTATCGTCGACGGTACGCAGACCCGGGTCAGCGGTCAGCACCTGATCAAGACCTTGGTCTGGTGTGATAATGAATGG
GGCTTTGCCAACCGGATGTTGGATACAACACGGGCAATGGCCGCAAGCGGTTTCTAG

Upstream 100 bases:

>100_bases
CGCTAAAGTACTCTATGCGGGTTATCCAGATAACCCAGTCAGCGCCCTCTCGACAACGGTGAGTACGCCCGGTGAGGGAA
GGCCCTTTTTCAGGAGCAGC

Downstream 100 bases:

>100_bases
TACGGCGGCATCGGCACGACCGATGCGCCGCTCAGGCAACTTTATAGTTTCTAGAGAATCAACCAAGAGGGTTCACCATG
TCTGTAATTAACATGTCCGA

Product: erythrose 4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MTIRIAINGFGRIGRSVLRALYESGRRAEISVVAINELANAEGMAHLLKYDSSHGRFAWDVRQECDMLTVGDDTIRLLHQ
PAVEQLPWGELGVDVVLDCSGVYGSRADGEAHLAAGAKKVLFAHPGGNDLDATIVFGVNHQTLLAEHRIVSNASCTTNCI
IPVIKLLDDAYSIESGTLTTIHSSMNDQPVIDAYHQDLRRTRAASQSIIPVDTKLAAGITRIFPQFCDRFEAISVRVPTI
NVTAIDLSVSVSSAVKVTEVNQLLQMAARGSFRGIVDYTELPLVSIDFNHDPHSAIVDGTQTRVSGQHLIKTLVWCDNEW
GFANRMLDTTRAMAASGF

Sequences:

>Translated_338_residues
MTIRIAINGFGRIGRSVLRALYESGRRAEISVVAINELANAEGMAHLLKYDSSHGRFAWDVRQECDMLTVGDDTIRLLHQ
PAVEQLPWGELGVDVVLDCSGVYGSRADGEAHLAAGAKKVLFAHPGGNDLDATIVFGVNHQTLLAEHRIVSNASCTTNCI
IPVIKLLDDAYSIESGTLTTIHSSMNDQPVIDAYHQDLRRTRAASQSIIPVDTKLAAGITRIFPQFCDRFEAISVRVPTI
NVTAIDLSVSVSSAVKVTEVNQLLQMAARGSFRGIVDYTELPLVSIDFNHDPHSAIVDGTQTRVSGQHLIKTLVWCDNEW
GFANRMLDTTRAMAASGF
>Mature_337_residues
TIRIAINGFGRIGRSVLRALYESGRRAEISVVAINELANAEGMAHLLKYDSSHGRFAWDVRQECDMLTVGDDTIRLLHQP
AVEQLPWGELGVDVVLDCSGVYGSRADGEAHLAAGAKKVLFAHPGGNDLDATIVFGVNHQTLLAEHRIVSNASCTTNCII
PVIKLLDDAYSIESGTLTTIHSSMNDQPVIDAYHQDLRRTRAASQSIIPVDTKLAAGITRIFPQFCDRFEAISVRVPTIN
VTAIDLSVSVSSAVKVTEVNQLLQMAARGSFRGIVDYTELPLVSIDFNHDPHSAIVDGTQTRVSGQHLIKTLVWCDNEWG
FANRMLDTTRAMAASGF

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=336, Percent_Identity=34.2261904761905, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI7657116, Length=334, Percent_Identity=35.0299401197605, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1789295, Length=338, Percent_Identity=82.5443786982248, Blast_Score=583, Evalue=1e-168,
Organism=Escherichia coli, GI1788079, Length=329, Percent_Identity=38.6018237082067, Blast_Score=242, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17534677, Length=343, Percent_Identity=36.1516034985423, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17534679, Length=343, Percent_Identity=35.8600583090379, Blast_Score=225, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI32566163, Length=338, Percent_Identity=35.5029585798817, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17568413, Length=338, Percent_Identity=35.5029585798817, Blast_Score=220, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6321631, Length=336, Percent_Identity=36.0119047619048, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6322409, Length=336, Percent_Identity=36.6071428571429, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6322468, Length=336, Percent_Identity=35.4166666666667, Blast_Score=235, Evalue=7e-63,
Organism=Drosophila melanogaster, GI17933600, Length=332, Percent_Identity=34.9397590361446, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI18110149, Length=332, Percent_Identity=34.9397590361446, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI85725000, Length=332, Percent_Identity=34.9397590361446, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI22023983, Length=332, Percent_Identity=34.9397590361446, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI19922412, Length=326, Percent_Identity=33.4355828220859, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.72 [H]

Molecular weight: Translated: 36824; Mature: 36693

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00071 GAPDH ; PS00090 NITROGENASE_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRIAINGFGRIGRSVLRALYESGRRAEISVVAINELANAEGMAHLLKYDSSHGRFAWD
CEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECHHCCHHHHHHHHHCCCCCCCEEEE
VRQECDMLTVGDDTIRLLHQPAVEQLPWGELGVDVVLDCSGVYGSRADGEAHLAAGAKKV
HHHCCCEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCCEEE
LFAHPGGNDLDATIVFGVNHQTLLAEHRIVSNASCTTNCIIPVIKLLDDAYSIESGTLTT
EEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEE
IHSSMNDQPVIDAYHQDLRRTRAASQSIIPVDTKLAAGITRIFPQFCDRFEAISVRVPTI
EECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECEE
NVTAIDLSVSVSSAVKVTEVNQLLQMAARGSFRGIVDYTELPLVSIDFNHDPHSAIVDGT
EEEEEEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEECCCCCEEEEECCCCCCCCEECCC
QTRVSGQHLIKTLVWCDNEWGFANRMLDTTRAMAASGF
HHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIRIAINGFGRIGRSVLRALYESGRRAEISVVAINELANAEGMAHLLKYDSSHGRFAWD
EEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECHHCCHHHHHHHHHCCCCCCCEEEE
VRQECDMLTVGDDTIRLLHQPAVEQLPWGELGVDVVLDCSGVYGSRADGEAHLAAGAKKV
HHHCCCEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCCEEE
LFAHPGGNDLDATIVFGVNHQTLLAEHRIVSNASCTTNCIIPVIKLLDDAYSIESGTLTT
EEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEE
IHSSMNDQPVIDAYHQDLRRTRAASQSIIPVDTKLAAGITRIFPQFCDRFEAISVRVPTI
EECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECEE
NVTAIDLSVSVSSAVKVTEVNQLLQMAARGSFRGIVDYTELPLVSIDFNHDPHSAIVDGT
EEEEEEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEECCCCCEEEEECCCCCCCCEECCC
QTRVSGQHLIKTLVWCDNEWGFANRMLDTTRAMAASGF
HHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA