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The map label for this gene is creC [H]

Identifier: 157372129

GI number: 157372129

Start: 4315864

End: 4317282

Strand: Reverse

Name: creC [H]

Synonym: Spro_3895

Alternate gene names: 157372129

Gene position: 4317282-4315864 (Counterclockwise)

Preceding gene: 157372130

Following gene: 157372128

Centisome position: 79.23

GC content: 59.34

Gene sequence:

>1419_bases
ATGAGAATAGGCCTGCGCCTGCTGTTGGGGTACTTCCTGATTGTGGCGGTGGCGGGCTATTTCGTACTGAGCATTTTCGT
GCAGGAAGTGAAACCCGGCGTGCGGCGCGCTACCGAAGGCACACTGGTGGACACTGCCAACCTGCTGGCGCAGATTGCAC
GTCTGGACATGCAGCGCGCCGACGTAGCGCACGGGCAACTGGCGCAGGCGTTCTCTCAACTCAATCAACGCCCCATTGGC
GCCAATATTGCCGGCATCCGCAAGGATCGCAGCGAATATCACGTTTATCTTACCGATCAAAACGGCAAGGTCATTTTTGA
TTCCAGCGGCAAGGCGCTCGGCCAGGACTACTCACGCTGGAATGACGTTTATCTGACGCTGCTTGGCCAGTACGGCGCAC
GCAGCACGCGCAGCGATCCGCAGGATGAAAACAGCTCGGTGATGTATGTTGCCGCGCCGGTCATGGAGCAGGGGAAAATT
ATCGGTGTGCTGAGCGTCGGTAAACCGAACAGCACCATGGTACCGGTGATCAAGCGCAGTGAACGCCGTATTCTGTGGGC
CGGTGCGCTGCTGTTGGGCATTGCCTTGCTGATTGGCCTGGGCTTTGTCTGGTGGATCAACCGCTCGATTGGGCGGCTGG
TGTACTACGCCAACGGCGTGGCGCAGGGAAAAAGTGTGCCGTTGCCGAAGATGGGCGGCCATGAATTGACCCAGTTGGCG
CAGGCGCTGGACAGCATGCGGGTGAAGCTGGAGGGCAAGGCCTACATCGAACAGTATGTACATACCCTGACCCATGAACT
GAAAAGCCCGTTGGCGGCGATCCGCGGTGCGGCCGAGCTGTTGCAGGAACAGCCGCCGGCAGCCACCGCCCAGCGTTTTC
TGACCAATATCGAACAGCAGAGTGCGCGCATTCAGCAGCTGGTGGATAAATTGCTGGTGCAGGCGCGGCTGGAGAGCCGG
CCGGCCCTGGATCTTGTGCCACTGGCCATGGCGACGCTGGTGCGTCAGGCTGTGGCAGGCAAAGAGGCGCAGGCAGCGCG
GCGTAGCGTTTTGCTACAGGTTGAAGGAGTGGAAGATATCACCCTGAACGGCGATGGACTGCTGATTAGCCAGGCGCTGA
CCAACCTGCTGGACAACGCATTGGACTTCACCCCGGTTGGCGGTACCATCAAGGTGCGCGGTGAGCGCCATGAGGGCCAC
TACCAGGTCACCGTTAGTGACGACGGCAGCGGCATTCCGGATTATGCACTGGATAAAGTGTTCGAGCGTTTTTATTCTCT
GGCCCGCTCGGATAAGCCGAAAAGCAGCGGTCTGGGGCTGAATTTTGTGCAGGAAGTGGCGCGCTTGCACCGTGGCAGTA
TCCAGTTGAGCAACCGTCAGCCGCACGGCGTGACCGCTATTTTCACCTTATCGCTCTGA

Upstream 100 bases:

>100_bases
CCCATATCAAAACGTTGCGTGCCAAGCTGCGCGCCATCGATCCCGCTGAACCCCCGATCCACACTCATCGCGGCCTCGGC
TACAGCGTGAGCCGCCAGCC

Downstream 100 bases:

>100_bases
CTTCACCGTCCCTTCACATAACCACATTCTGCTTTCACCCGAGGGCATTATCGTGACTCCATTACCTACATGGAGCGCGG
CGATGATGAAATCGATACTG

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MRIGLRLLLGYFLIVAVAGYFVLSIFVQEVKPGVRRATEGTLVDTANLLAQIARLDMQRADVAHGQLAQAFSQLNQRPIG
ANIAGIRKDRSEYHVYLTDQNGKVIFDSSGKALGQDYSRWNDVYLTLLGQYGARSTRSDPQDENSSVMYVAAPVMEQGKI
IGVLSVGKPNSTMVPVIKRSERRILWAGALLLGIALLIGLGFVWWINRSIGRLVYYANGVAQGKSVPLPKMGGHELTQLA
QALDSMRVKLEGKAYIEQYVHTLTHELKSPLAAIRGAAELLQEQPPAATAQRFLTNIEQQSARIQQLVDKLLVQARLESR
PALDLVPLAMATLVRQAVAGKEAQAARRSVLLQVEGVEDITLNGDGLLISQALTNLLDNALDFTPVGGTIKVRGERHEGH
YQVTVSDDGSGIPDYALDKVFERFYSLARSDKPKSSGLGLNFVQEVARLHRGSIQLSNRQPHGVTAIFTLSL

Sequences:

>Translated_472_residues
MRIGLRLLLGYFLIVAVAGYFVLSIFVQEVKPGVRRATEGTLVDTANLLAQIARLDMQRADVAHGQLAQAFSQLNQRPIG
ANIAGIRKDRSEYHVYLTDQNGKVIFDSSGKALGQDYSRWNDVYLTLLGQYGARSTRSDPQDENSSVMYVAAPVMEQGKI
IGVLSVGKPNSTMVPVIKRSERRILWAGALLLGIALLIGLGFVWWINRSIGRLVYYANGVAQGKSVPLPKMGGHELTQLA
QALDSMRVKLEGKAYIEQYVHTLTHELKSPLAAIRGAAELLQEQPPAATAQRFLTNIEQQSARIQQLVDKLLVQARLESR
PALDLVPLAMATLVRQAVAGKEAQAARRSVLLQVEGVEDITLNGDGLLISQALTNLLDNALDFTPVGGTIKVRGERHEGH
YQVTVSDDGSGIPDYALDKVFERFYSLARSDKPKSSGLGLNFVQEVARLHRGSIQLSNRQPHGVTAIFTLSL
>Mature_472_residues
MRIGLRLLLGYFLIVAVAGYFVLSIFVQEVKPGVRRATEGTLVDTANLLAQIARLDMQRADVAHGQLAQAFSQLNQRPIG
ANIAGIRKDRSEYHVYLTDQNGKVIFDSSGKALGQDYSRWNDVYLTLLGQYGARSTRSDPQDENSSVMYVAAPVMEQGKI
IGVLSVGKPNSTMVPVIKRSERRILWAGALLLGIALLIGLGFVWWINRSIGRLVYYANGVAQGKSVPLPKMGGHELTQLA
QALDSMRVKLEGKAYIEQYVHTLTHELKSPLAAIRGAAELLQEQPPAATAQRFLTNIEQQSARIQQLVDKLLVQARLESR
PALDLVPLAMATLVRQAVAGKEAQAARRSVLLQVEGVEDITLNGDGLLISQALTNLLDNALDFTPVGGTIKVRGERHEGH
YQVTVSDDGSGIPDYALDKVFERFYSLARSDKPKSSGLGLNFVQEVARLHRGSIQLSNRQPHGVTAIFTLSL

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=470, Percent_Identity=62.7659574468085, Blast_Score=587, Evalue=1e-169,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=27.7272727272727, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788393, Length=237, Percent_Identity=28.2700421940928, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082128, Length=279, Percent_Identity=27.5985663082437, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1786783, Length=240, Percent_Identity=28.75, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=27.8026905829596, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788549, Length=213, Percent_Identity=28.6384976525822, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=26.8867924528302, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI145693157, Length=221, Percent_Identity=26.2443438914027, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788279, Length=238, Percent_Identity=27.3109243697479, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790551, Length=293, Percent_Identity=26.962457337884, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789403, Length=238, Percent_Identity=29.8319327731092, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790300, Length=231, Percent_Identity=27.7056277056277, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=264, Percent_Identity=24.6212121212121, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789808, Length=282, Percent_Identity=26.9503546099291, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790346, Length=268, Percent_Identity=25, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=28.8990825688073, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=24.2290748898678, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51666; Mature: 51666

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGLRLLLGYFLIVAVAGYFVLSIFVQEVKPGVRRATEGTLVDTANLLAQIARLDMQRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
DVAHGQLAQAFSQLNQRPIGANIAGIRKDRSEYHVYLTDQNGKVIFDSSGKALGQDYSRW
HHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCEEEEEECCCCEEEECCCCCHHHHHHHHH
NDVYLTLLGQYGARSTRSDPQDENSSVMYVAAPVMEQGKIIGVLSVGKPNSTMVPVIKRS
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHCCCEEEEEECCCCCCCEEHHHHCC
ERRILWAGALLLGIALLIGLGFVWWINRSIGRLVYYANGVAQGKSVPLPKMGGHELTQLA
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHH
QALDSMRVKLEGKAYIEQYVHTLTHELKSPLAAIRGAAELLQEQPPAATAQRFLTNIEQQ
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SARIQQLVDKLLVQARLESRPALDLVPLAMATLVRQAVAGKEAQAARRSVLLQVEGVEDI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEEECCCEE
TLNGDGLLISQALTNLLDNALDFTPVGGTIKVRGERHEGHYQVTVSDDGSGIPDYALDKV
EECCCCEEHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHH
FERFYSLARSDKPKSSGLGLNFVQEVARLHRGSIQLSNRQPHGVTAIFTLSL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEEEEEC
>Mature Secondary Structure
MRIGLRLLLGYFLIVAVAGYFVLSIFVQEVKPGVRRATEGTLVDTANLLAQIARLDMQRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
DVAHGQLAQAFSQLNQRPIGANIAGIRKDRSEYHVYLTDQNGKVIFDSSGKALGQDYSRW
HHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCEEEEEECCCCEEEECCCCCHHHHHHHHH
NDVYLTLLGQYGARSTRSDPQDENSSVMYVAAPVMEQGKIIGVLSVGKPNSTMVPVIKRS
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHCCCEEEEEECCCCCCCEEHHHHCC
ERRILWAGALLLGIALLIGLGFVWWINRSIGRLVYYANGVAQGKSVPLPKMGGHELTQLA
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHH
QALDSMRVKLEGKAYIEQYVHTLTHELKSPLAAIRGAAELLQEQPPAATAQRFLTNIEQQ
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SARIQQLVDKLLVQARLESRPALDLVPLAMATLVRQAVAGKEAQAARRSVLLQVEGVEDI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEEECCCEE
TLNGDGLLISQALTNLLDNALDFTPVGGTIKVRGERHEGHYQVTVSDDGSGIPDYALDKV
EECCCCEEHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHH
FERFYSLARSDKPKSSGLGLNFVQEVARLHRGSIQLSNRQPHGVTAIFTLSL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]