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The map label for this gene is lysA [H]

Identifier: 157372071

GI number: 157372071

Start: 4246160

End: 4247422

Strand: Reverse

Name: lysA [H]

Synonym: Spro_3836

Alternate gene names: 157372071

Gene position: 4247422-4246160 (Counterclockwise)

Preceding gene: 157372073

Following gene: 157372068

Centisome position: 77.95

GC content: 57.72

Gene sequence:

>1263_bases
ATGCCACGTGCTCTCGACGACACCACTACCGCTCTTAATACCGCTAACCTGCTGGCCTTGCCTGGGCGTTTTGGTTGCCC
GGTATGGGCCTATGACGCCGCTATCATTAGCGAGCGCATCAGCCAGCTGCGTCATTTCGATGTTATTCGTTTTGCCCAAA
AGGCCTGCTCGAATATCCATATTCTGCGCCTGATGCGTGAGCAGGGCGTCAAGGTGGACTCGGTGTCGTTGGGGGAGATT
GAGCGTGCATTGCAGGCCGGTTTTCAGCCGGGTGGTGAGCCAAGTGAGATTGTGTTTACCGCCGACGTGCTGGATCACGC
GACCCTGGCGCGCGTCAGCGAATTGAAAATTCCGGTTAACGTCGGTTCGATCGACATGCTGGAACAACTGGGCCAGGTTT
CTACCGGACATCCAGTGTGGCTGCGCATCAACCCAGGCTTTGGGCACGGCCACAGCCAGAAAACCAATACCGGCGGCGAG
AACAGCAAGCACGGCATTTGGTATGCCGATTTACCGCAGGCGGTGGAGAAAATTCAGCAGTACGGCCTGAAATTGATTGG
TGTGCATATGCATATCGGTTCGGGGGTGGATTACCAGCATCTGGAGCGGGTGTGTGACGCCATGGTGCAGCAGGTGATCG
ATCTCGGTCAGGATATCAGCGCCATTTCCGCCGGTGGCGGCCTGTCGATCCCTTATCAGTACGGTGAAGAGGCGATTGAT
ACCGAGCACTATTTTGGCCTGTGGAACAGTGCCCGTGAGCGCATTGCCGCGCATCTGGGGCATCCGGTGAGCCTGGAGAT
TGAACCTGGGCGTTTCCTGATGGCAGAAGCCGGGGTGCTGGTGGCCGAGGTACGCGCGGTGAAAGACATGGGCAGCCGCC
ACTTTGTGCTGGTAGACGCCGGTTTTAACGATTTGATGCGTCCGGCGATGTACGGCAGTTACCACCATATTTCTCTGCTG
CCGGCCGATGGCCGCGATACAGCCAACCAGCCGCTGCGCGATACCGTGATTGCCGGGCCGCTGTGCGAATCCGGTGATGT
CTTTACCCAGCAGGCCGGTGGTGGCATTGAAACCCGCGAACTGCCGCCGGTGCAGGTCGGTGATTATTTGGTGTTCCATG
ACACCGGTGCTTACGGCGCGTCAATGTCATCGAACTACAACAGCCGTCCATTGCTGCCGGAAGTGCTGTTTGAAAACGGC
GAAGCGCGATTGATTCGCCGCCGCCAGACCATTGAAGAGCTGATTGCGCTGGAACTGATCTGA

Upstream 100 bases:

>100_bases
TAAATGAATAGACTCTGGCTAAATAGATATTTTCCATCCAAGAAAGCGTGCGGCAATATTGGGGTATTAGAGTCACTAAA
TTTTATTCAGGGATACCACC

Downstream 100 bases:

>100_bases
TGCTCTCGGGCGCAGTTTAATACTGCGCCCGTTTCACAGAGACATGCGCCGGTGCTGGCCGTTGGGGAGTTGGACTTCCA
GCGACAGCGTACCGCCCATG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MPRALDDTTTALNTANLLALPGRFGCPVWAYDAAIISERISQLRHFDVIRFAQKACSNIHILRLMREQGVKVDSVSLGEI
ERALQAGFQPGGEPSEIVFTADVLDHATLARVSELKIPVNVGSIDMLEQLGQVSTGHPVWLRINPGFGHGHSQKTNTGGE
NSKHGIWYADLPQAVEKIQQYGLKLIGVHMHIGSGVDYQHLERVCDAMVQQVIDLGQDISAISAGGGLSIPYQYGEEAID
TEHYFGLWNSARERIAAHLGHPVSLEIEPGRFLMAEAGVLVAEVRAVKDMGSRHFVLVDAGFNDLMRPAMYGSYHHISLL
PADGRDTANQPLRDTVIAGPLCESGDVFTQQAGGGIETRELPPVQVGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFENG
EARLIRRRQTIEELIALELI

Sequences:

>Translated_420_residues
MPRALDDTTTALNTANLLALPGRFGCPVWAYDAAIISERISQLRHFDVIRFAQKACSNIHILRLMREQGVKVDSVSLGEI
ERALQAGFQPGGEPSEIVFTADVLDHATLARVSELKIPVNVGSIDMLEQLGQVSTGHPVWLRINPGFGHGHSQKTNTGGE
NSKHGIWYADLPQAVEKIQQYGLKLIGVHMHIGSGVDYQHLERVCDAMVQQVIDLGQDISAISAGGGLSIPYQYGEEAID
TEHYFGLWNSARERIAAHLGHPVSLEIEPGRFLMAEAGVLVAEVRAVKDMGSRHFVLVDAGFNDLMRPAMYGSYHHISLL
PADGRDTANQPLRDTVIAGPLCESGDVFTQQAGGGIETRELPPVQVGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFENG
EARLIRRRQTIEELIALELI
>Mature_419_residues
PRALDDTTTALNTANLLALPGRFGCPVWAYDAAIISERISQLRHFDVIRFAQKACSNIHILRLMREQGVKVDSVSLGEIE
RALQAGFQPGGEPSEIVFTADVLDHATLARVSELKIPVNVGSIDMLEQLGQVSTGHPVWLRINPGFGHGHSQKTNTGGEN
SKHGIWYADLPQAVEKIQQYGLKLIGVHMHIGSGVDYQHLERVCDAMVQQVIDLGQDISAISAGGGLSIPYQYGEEAIDT
EHYFGLWNSARERIAAHLGHPVSLEIEPGRFLMAEAGVLVAEVRAVKDMGSRHFVLVDAGFNDLMRPAMYGSYHHISLLP
ADGRDTANQPLRDTVIAGPLCESGDVFTQQAGGGIETRELPPVQVGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFENGE
ARLIRRRQTIEELIALELI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=76.6423357664234, Blast_Score=672, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45928; Mature: 45797

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRALDDTTTALNTANLLALPGRFGCPVWAYDAAIISERISQLRHFDVIRFAQKACSNIH
CCCCCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILRLMREQGVKVDSVSLGEIERALQAGFQPGGEPSEIVFTADVLDHATLARVSELKIPVN
HHHHHHHCCCEECCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHEEEEEC
VGSIDMLEQLGQVSTGHPVWLRINPGFGHGHSQKTNTGGENSKHGIWYADLPQAVEKIQQ
CCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHH
YGLKLIGVHMHIGSGVDYQHLERVCDAMVQQVIDLGQDISAISAGGGLSIPYQYGEEAID
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHCCHHHC
TEHYFGLWNSARERIAAHLGHPVSLEIEPGRFLMAEAGVLVAEVRAVKDMGSRHFVLVDA
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEC
GFNDLMRPAMYGSYHHISLLPADGRDTANQPLRDTVIAGPLCESGDVFTQQAGGGIETRE
CHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHEECCCCCCCCCEECCCCCCCCCCC
LPPVQVGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFENGEARLIRRRQTIEELIALELI
CCCCEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRALDDTTTALNTANLLALPGRFGCPVWAYDAAIISERISQLRHFDVIRFAQKACSNIH
CCCCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILRLMREQGVKVDSVSLGEIERALQAGFQPGGEPSEIVFTADVLDHATLARVSELKIPVN
HHHHHHHCCCEECCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHEEEEEC
VGSIDMLEQLGQVSTGHPVWLRINPGFGHGHSQKTNTGGENSKHGIWYADLPQAVEKIQQ
CCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHH
YGLKLIGVHMHIGSGVDYQHLERVCDAMVQQVIDLGQDISAISAGGGLSIPYQYGEEAID
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHCCHHHC
TEHYFGLWNSARERIAAHLGHPVSLEIEPGRFLMAEAGVLVAEVRAVKDMGSRHFVLVDA
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEC
GFNDLMRPAMYGSYHHISLLPADGRDTANQPLRDTVIAGPLCESGDVFTQQAGGGIETRE
CHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHEECCCCCCCCCEECCCCCCCCCCC
LPPVQVGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFENGEARLIRRRQTIEELIALELI
CCCCEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350601; 9278503 [H]