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The map label for this gene is cadB [H]

Identifier: 157372003

GI number: 157372003

Start: 4163917

End: 4165266

Strand: Reverse

Name: cadB [H]

Synonym: Spro_3768

Alternate gene names: 157372003

Gene position: 4165266-4163917 (Counterclockwise)

Preceding gene: 157372004

Following gene: 157372002

Centisome position: 76.44

GC content: 56.0

Gene sequence:

>1350_bases
ATGGGTTCATCCAAGAAAATAGGGCTTATTGCCTGCACCGGTGTGGTTGCCGGTAATATGATGGGGAGCGGTATTGCCTT
ATTACCCGCGAACCTGGCAAGCCTCGGTTCTATCGCCATCTGGGGATGGGTAATCTCTATTATTGGCGCGATGTCACTGG
CTTATGTCTATGCGCGTCTGGCCACCAAAAACCCTCAGCAGGGTGGCCCTATTGCTTACGCGGGTGAAATTTCCCCGGCG
TTTGGTTTCCAGACCGGTGTGCTTTATTACCATGCGAACTGGATCGGTAATTTGGCCATCGGCATTACCGCAGTTTCTTA
TCTCTCTACCTTCTTCCCTGCATTGAATAATCCGGTACCGGCAGGTATTGCCTGTATCGCCATCGTCTGGATATTCACCT
TTGTTAACCTGCTTGGCGGGACCTGGGTCAGCCGCTTGACCACCCTCGGCCTGGTGCTGGTGCTGATCCCGGTGATTGTC
ACCGCGACTGCGGGCTGGCATTGGTTCGACGCTGCAACCTACCACGCTAACTGGAACACTTCCGGTACCACCGACAGCCA
TGCGGTAATCAAAAGTATTCTGCTGTGCCTGTGGGCGTTCATCGGCGTAGAGTCTGCCGCCGTGAGCACCGGCATGGTGA
AAAACCCGAAACGCACCGTACCGCTGGCAACCATGCTGGGTACCGCGCTGGCCGGGATTATCTACATTGCGGCCACTCAG
GTGATGAGCGGTATGTTCCCGGCTAGCCAAATGGCTGCCAGCGGTGCACCGTTCGCCGTCAGCGCCTCCGCCATTATGGG
TAACTGGGCTGCACCACTGGTCTCTGCCTTCACCGCCTTTGCCTGCCTGACTTCACTGGGTTCGTGGATGATGCTGGTTG
GCCAGGCCGGGGTTCGTGCCGCCAACGACGGTAACTTCCCGAAAGTTTATGGTGAAGTCGATAAAAACGGCGTGCCGAAA
AAAGGCCTGCTGCTGGCAAGCTGCAAAATGACCGCGCTGATGGTGCTGATTACCGCCATGAGCTCCGGCGGCGGTAAAGC
TTCCGACCTGTTCGGCATGCTGACCGGTATTGCGGTGCTGCTGACCATGTTGCCTTACTTCTACTCTTGCGTAGACCTGA
TCCGCTTCGAAGGCGTCAATATCCGTAACCTGTTGAGCCTGATTGCCTCGGTTCTGGGTTGTGGCTTCTGCTTCATCGCA
CTGATGGGGGCCGAATCGTTCGAACTGGCCGGTACCTTCATCATCAGCCTGATCATCCTGATGTTCTACGCCCGCAAAAT
GAATACCCGTCAGACAGCGAAAGCCAATGCTGTAGCCATCGACGACAGCTCGACGGCCAAAGCGCACTAA

Upstream 100 bases:

>100_bases
TTCCCGCCAATCATTAGCATCCTGACTATCAAGTCCGGTCATTAGCAAATTTGCTTAACGGCCAAGACTTATAAGAAATC
AAAATCAGGAGAAACTGACC

Downstream 100 bases:

>100_bases
GCACGTACTGACCCACTTCTTAATTCAGCCCCTTGCAACAACGATTGTCATCCGTGATGGCAAGGGGCTCGCATTACCTG
GAGAAATGATTATGAACGTT

Product: lysine/cadaverine antiporter

Products: cadaverine [Cytoplasm]; L-lysine [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MGSSKKIGLIACTGVVAGNMMGSGIALLPANLASLGSIAIWGWVISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPA
FGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPALNNPVPAGIACIAIVWIFTFVNLLGGTWVSRLTTLGLVLVLIPVIV
TATAGWHWFDAATYHANWNTSGTTDSHAVIKSILLCLWAFIGVESAAVSTGMVKNPKRTVPLATMLGTALAGIIYIAATQ
VMSGMFPASQMAASGAPFAVSASAIMGNWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDKNGVPK
KGLLLASCKMTALMVLITAMSSGGGKASDLFGMLTGIAVLLTMLPYFYSCVDLIRFEGVNIRNLLSLIASVLGCGFCFIA
LMGAESFELAGTFIISLIILMFYARKMNTRQTAKANAVAIDDSSTAKAH

Sequences:

>Translated_449_residues
MGSSKKIGLIACTGVVAGNMMGSGIALLPANLASLGSIAIWGWVISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPA
FGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPALNNPVPAGIACIAIVWIFTFVNLLGGTWVSRLTTLGLVLVLIPVIV
TATAGWHWFDAATYHANWNTSGTTDSHAVIKSILLCLWAFIGVESAAVSTGMVKNPKRTVPLATMLGTALAGIIYIAATQ
VMSGMFPASQMAASGAPFAVSASAIMGNWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDKNGVPK
KGLLLASCKMTALMVLITAMSSGGGKASDLFGMLTGIAVLLTMLPYFYSCVDLIRFEGVNIRNLLSLIASVLGCGFCFIA
LMGAESFELAGTFIISLIILMFYARKMNTRQTAKANAVAIDDSSTAKAH
>Mature_448_residues
GSSKKIGLIACTGVVAGNMMGSGIALLPANLASLGSIAIWGWVISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPAF
GFQTGVLYYHANWIGNLAIGITAVSYLSTFFPALNNPVPAGIACIAIVWIFTFVNLLGGTWVSRLTTLGLVLVLIPVIVT
ATAGWHWFDAATYHANWNTSGTTDSHAVIKSILLCLWAFIGVESAAVSTGMVKNPKRTVPLATMLGTALAGIIYIAATQV
MSGMFPASQMAASGAPFAVSASAIMGNWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDKNGVPKK
GLLLASCKMTALMVLITAMSSGGGKASDLFGMLTGIAVLLTMLPYFYSCVDLIRFEGVNIRNLLSLIASVLGCGFCFIAL
MGAESFELAGTFIISLIILMFYARKMNTRQTAKANAVAIDDSSTAKAH

Specific function: Probable cadaverine/lysine antiporter or part of it [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI186910308, Length=327, Percent_Identity=27.5229357798165, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI186910306, Length=327, Percent_Identity=27.5229357798165, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI186910304, Length=327, Percent_Identity=27.5229357798165, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI115648063, Length=370, Percent_Identity=26.4864864864865, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI115648022, Length=370, Percent_Identity=26.4864864864865, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790575, Length=449, Percent_Identity=86.1915367483296, Blast_Score=761, Evalue=0.0,
Organism=Escherichia coli, GI2367353, Length=429, Percent_Identity=40.0932400932401, Blast_Score=314, Evalue=6e-87,
Organism=Escherichia coli, GI1786908, Length=381, Percent_Identity=32.5459317585302, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1787890, Length=442, Percent_Identity=24.8868778280543, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87082250, Length=341, Percent_Identity=26.3929618768328, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71982608, Length=347, Percent_Identity=25.3602305475504, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71982612, Length=347, Percent_Identity=25.3602305475504, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321492, Length=268, Percent_Identity=22.3880597014925, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221331183, Length=298, Percent_Identity=26.510067114094, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17647653, Length=298, Percent_Identity=26.510067114094, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664379, Length=298, Percent_Identity=26.510067114094, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46839; Mature: 46708

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSSKKIGLIACTGVVAGNMMGSGIALLPANLASLGSIAIWGWVISIIGAMSLAYVYARL
CCCCCCEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATKNPQQGGPIAYAGEISPAFGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPALNNPVP
HCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGIACIAIVWIFTFVNLLGGTWVSRLTTLGLVLVLIPVIVTATAGWHWFDAATYHANWNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEECCCCC
SGTTDSHAVIKSILLCLWAFIGVESAAVSTGMVKNPKRTVPLATMLGTALAGIIYIAATQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VMSGMFPASQMAASGAPFAVSASAIMGNWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRA
HHHCCCCHHHHHCCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ANDGNFPKVYGEVDKNGVPKKGLLLASCKMTALMVLITAMSSGGGKASDLFGMLTGIAVL
CCCCCCCCEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LTMLPYFYSCVDLIRFEGVNIRNLLSLIASVLGCGFCFIALMGAESFELAGTFIISLIIL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MFYARKMNTRQTAKANAVAIDDSSTAKAH
HHHHHHCCCHHHCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
GSSKKIGLIACTGVVAGNMMGSGIALLPANLASLGSIAIWGWVISIIGAMSLAYVYARL
CCCCCEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATKNPQQGGPIAYAGEISPAFGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPALNNPVP
HCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGIACIAIVWIFTFVNLLGGTWVSRLTTLGLVLVLIPVIVTATAGWHWFDAATYHANWNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEECCCCC
SGTTDSHAVIKSILLCLWAFIGVESAAVSTGMVKNPKRTVPLATMLGTALAGIIYIAATQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VMSGMFPASQMAASGAPFAVSASAIMGNWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRA
HHHCCCCHHHHHCCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ANDGNFPKVYGEVDKNGVPKKGLLLASCKMTALMVLITAMSSGGGKASDLFGMLTGIAVL
CCCCCCCCEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LTMLPYFYSCVDLIRFEGVNIRNLLSLIASVLGCGFCFIALMGAESFELAGTFIISLIIL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MFYARKMNTRQTAKANAVAIDDSSTAKAH
HHHHHHCCCHHHCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cadaverine [Cytoplasm]; Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: cadaverine [Cytoplasm] + Proton [Periplasm] + L-lysine [Periplasm] = cadaverine [Cytoplasm] + L-lysine [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]