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The map label for this gene is cimH [H]

Identifier: 157371965

GI number: 157371965

Start: 4117675

End: 4119030

Strand: Reverse

Name: cimH [H]

Synonym: Spro_3730

Alternate gene names: 157371965

Gene position: 4119030-4117675 (Counterclockwise)

Preceding gene: 157371972

Following gene: 157371964

Centisome position: 75.59

GC content: 55.38

Gene sequence:

>1356_bases
ATGAGCACAACAGATGATTCTTACCTCGTCGCCAAAGATAAAGCCGCTGAAATACCATTGCGTGAAAAATGGTGGCACAT
ACTGGATAACTACAAAGTAGGGATTATTCCGTTGCCGTTCTTTGTTCTGGCCGGCGTGCTTATTTTACTTGATTGCCTTG
AAGGGAAATTACCCAGCGATATCGTAGTGATGGTCGCAACGCTGGCCTTCTTTGGTTTTGCCTGCGGTGAGTTCGGTAAA
CGCCTGCCGCTGATCGGCAAAATGGGTGCCGCGGCGATCTGTGCCACCTTTATTCCTTCCGCACTGGTGCATTACGGCCT
GCTGCCGGATGTAGTGGTGGAGTCGACCACCAAATTCTATAAGTCGACCAATATTCTGTACCTGTATATCTGCTGCATTA
TCGTCGGCAGCATTATGAGTATGAATCGTCAGGTGCTGATCCAGGGCTTCCTGCGCATCTTCGTACCGATGCTGTGCGGT
GAGATTGCCGGCATGCTGGTGGGCATGGCCGTTGGTATGGCTCTTGGGCTGGAACCCTTCCAGATCTTCTTCTTCCTGAT
CTTGCCAATCATGGCCGGGGGCGTCGGTGAGGGCGCGATCCCGCTGTCGATGGGCTACGCGGCGATTTTGCATATGGAGC
AGGGGGTGGCGTTAGGTCGTATTTTGCCGATCGTGATGCTCGGCAGTCTGACCGCCATTGTGCTTGCCGGCTTGCTGAAT
CAACTCGGTAAACGCTACCCGCACCTGACCGGTGAGGGCAGCCTGATGCCGAGCAAGCAGGGTGACAGCGCAATGAGCGC
GGTGGATAAAATCAGCGGCAAGGTGGATGTCAGTACCATTGCCTGTGGCGCGCTGCTGGCCATTTTGCTGTACATGGTCG
GGATGCTGCTGCACCGCATGATTGGCCTGCCTGCACCGGTTGGCATGCTGTTCGCGGCGGTAGCGGTGAAGCTGGCACAC
GGTGTTTCCCCACGCATTCAGGAAGGTTCGCAGGTGGTGTATAAGTTCTTCCGCACGGCGGTGACCTACCCAATCCTGTT
TGCCGTTGGCGTAGCCATCACCCCATGGCAGGAACTGGTTAACGCCTTCACTCTCCAAAACCTGGTGGTGATTGTCAGCA
CCGTTTCTACCCTGGTGGCGACCGGTTTCTTCGTCGGTAAAAAAATTGGCATGCACCCGATAGACGTGGCGATTGTCTCC
TGCTGCCAAAGCGGGCAGGGCGGCACCGGTGATGTGGCCATCCTGACTGCCGGTAACCGCATGTCGCTGATGCCGTTTGC
CCAGATCGCCACCCGTATCGGCGGTGCGATCAACGTCTCACTCTCTTTGTTAGTCCTGGCCAAATTCTTCGTATAA

Upstream 100 bases:

>100_bases
TAACCACCATTAAAAACCCTTTTTTATTTTGAACAAAATCACAGCAGATAATCCGTGCGTTTCTCTATGATGGTTGAACA
AACTAATAAGAGGCCAGATT

Downstream 100 bases:

>100_bases
CAAAAAAAACTCAGTTTTCTTTGCCTTTCCCCGCCCCCGCGGGGATTTTTTTTGCCTGTGTCATTGCTCTTGCGGGCAGG
CTCTGGGTTTTGCGTCAATA

Product: citrate carrier protein

Products: NA

Alternate protein names: Citrate/malate-proton symporter [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSTTDDSYLVAKDKAAEIPLREKWWHILDNYKVGIIPLPFFVLAGVLILLDCLEGKLPSDIVVMVATLAFFGFACGEFGK
RLPLIGKMGAAAICATFIPSALVHYGLLPDVVVESTTKFYKSTNILYLYICCIIVGSIMSMNRQVLIQGFLRIFVPMLCG
EIAGMLVGMAVGMALGLEPFQIFFFLILPIMAGGVGEGAIPLSMGYAAILHMEQGVALGRILPIVMLGSLTAIVLAGLLN
QLGKRYPHLTGEGSLMPSKQGDSAMSAVDKISGKVDVSTIACGALLAILLYMVGMLLHRMIGLPAPVGMLFAAVAVKLAH
GVSPRIQEGSQVVYKFFRTAVTYPILFAVGVAITPWQELVNAFTLQNLVVIVSTVSTLVATGFFVGKKIGMHPIDVAIVS
CCQSGQGGTGDVAILTAGNRMSLMPFAQIATRIGGAINVSLSLLVLAKFFV

Sequences:

>Translated_451_residues
MSTTDDSYLVAKDKAAEIPLREKWWHILDNYKVGIIPLPFFVLAGVLILLDCLEGKLPSDIVVMVATLAFFGFACGEFGK
RLPLIGKMGAAAICATFIPSALVHYGLLPDVVVESTTKFYKSTNILYLYICCIIVGSIMSMNRQVLIQGFLRIFVPMLCG
EIAGMLVGMAVGMALGLEPFQIFFFLILPIMAGGVGEGAIPLSMGYAAILHMEQGVALGRILPIVMLGSLTAIVLAGLLN
QLGKRYPHLTGEGSLMPSKQGDSAMSAVDKISGKVDVSTIACGALLAILLYMVGMLLHRMIGLPAPVGMLFAAVAVKLAH
GVSPRIQEGSQVVYKFFRTAVTYPILFAVGVAITPWQELVNAFTLQNLVVIVSTVSTLVATGFFVGKKIGMHPIDVAIVS
CCQSGQGGTGDVAILTAGNRMSLMPFAQIATRIGGAINVSLSLLVLAKFFV
>Mature_450_residues
STTDDSYLVAKDKAAEIPLREKWWHILDNYKVGIIPLPFFVLAGVLILLDCLEGKLPSDIVVMVATLAFFGFACGEFGKR
LPLIGKMGAAAICATFIPSALVHYGLLPDVVVESTTKFYKSTNILYLYICCIIVGSIMSMNRQVLIQGFLRIFVPMLCGE
IAGMLVGMAVGMALGLEPFQIFFFLILPIMAGGVGEGAIPLSMGYAAILHMEQGVALGRILPIVMLGSLTAIVLAGLLNQ
LGKRYPHLTGEGSLMPSKQGDSAMSAVDKISGKVDVSTIACGALLAILLYMVGMLLHRMIGLPAPVGMLFAAVAVKLAHG
VSPRIQEGSQVVYKFFRTAVTYPILFAVGVAITPWQELVNAFTLQNLVVIVSTVSTLVATGFFVGKKIGMHPIDVAIVSC
CQSGQGGTGDVAILTAGNRMSLMPFAQIATRIGGAINVSLSLLVLAKFFV

Specific function: Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictl

COG id: COG3493

COG function: function code C; Na+/citrate symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:citrate (SCF) symporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004679
- InterPro:   IPR018025 [H]

Pfam domain/function: PF03390 2HCT [H]

EC number: NA

Molecular weight: Translated: 47910; Mature: 47779

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTDDSYLVAKDKAAEIPLREKWWHILDNYKVGIIPLPFFVLAGVLILLDCLEGKLPSD
CCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHCCCCCHH
IVVMVATLAFFGFACGEFGKRLPLIGKMGAAAICATFIPSALVHYGLLPDVVVESTTKFY
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KSTNILYLYICCIIVGSIMSMNRQVLIQGFLRIFVPMLCGEIAGMLVGMAVGMALGLEPF
HCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QIFFFLILPIMAGGVGEGAIPLSMGYAAILHMEQGVALGRILPIVMLGSLTAIVLAGLLN
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
QLGKRYPHLTGEGSLMPSKQGDSAMSAVDKISGKVDVSTIACGALLAILLYMVGMLLHRM
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IGLPAPVGMLFAAVAVKLAHGVSPRIQEGSQVVYKFFRTAVTYPILFAVGVAITPWQELV
HCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
NAFTLQNLVVIVSTVSTLVATGFFVGKKIGMHPIDVAIVSCCQSGQGGTGDVAILTAGNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCC
MSLMPFAQIATRIGGAINVSLSLLVLAKFFV
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
STTDDSYLVAKDKAAEIPLREKWWHILDNYKVGIIPLPFFVLAGVLILLDCLEGKLPSD
CCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHCCCCCHH
IVVMVATLAFFGFACGEFGKRLPLIGKMGAAAICATFIPSALVHYGLLPDVVVESTTKFY
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KSTNILYLYICCIIVGSIMSMNRQVLIQGFLRIFVPMLCGEIAGMLVGMAVGMALGLEPF
HCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QIFFFLILPIMAGGVGEGAIPLSMGYAAILHMEQGVALGRILPIVMLGSLTAIVLAGLLN
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
QLGKRYPHLTGEGSLMPSKQGDSAMSAVDKISGKVDVSTIACGALLAILLYMVGMLLHRM
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IGLPAPVGMLFAAVAVKLAHGVSPRIQEGSQVVYKFFRTAVTYPILFAVGVAITPWQELV
HCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
NAFTLQNLVVIVSTVSTLVATGFFVGKKIGMHPIDVAIVSCCQSGQGGTGDVAILTAGNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCC
MSLMPFAQIATRIGGAINVSLSLLVLAKFFV
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969509; 9384377; 11566984 [H]