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The map label for this gene is purC [H]

Identifier: 157371744

GI number: 157371744

Start: 3883152

End: 3883865

Strand: Reverse

Name: purC [H]

Synonym: Spro_3507

Alternate gene names: 157371744

Gene position: 3883865-3883152 (Counterclockwise)

Preceding gene: 157371745

Following gene: 157371743

Centisome position: 71.28

GC content: 52.94

Gene sequence:

>714_bases
ATGCAAAAGCTAGCTGAGCTGTATCGCGGAAAGGCAAAAACCGTCTACACCACTGAAAATCCTGATCTGCTGGTGTTGGA
ATTCCGCAATGATACGTCAGCACTGGATGGTCAGCGCATTGAGCAATTTGATCGCAAGGGTATGGTGAACAACAAGTTCA
ACCATTTCATCATGAGCAAACTGGAAGAAGCCGGCATCCCGACGCAAATGGAACGCCTGCTGTCAGACAACGAAGTTCTG
GTGAAGAAGTTGGACATGGTGCCGGTAGAGTGCGTGATCCGCAACCGTGCTGCCGGTTCACTGGTGAAGCGTTTGGGCAT
TGAAGAAGGCCTGGTACTGAACCCACCGCTGTTTGACCTGTTCCTGAAAAACGATGAAATGCACGATCCCATGGTCAACG
AATCCTACTGCGAAACCTTTGGTTGGGTGAACAAACAGCACCTGGCACGCATGCGTGAGCTGAGCTACCAGGCGAACGAC
GTGCTGAGCAAGCTGTTTGACGACGCAGGCCTGATCCTGGTCGACTTCAAGCTGGAGTTTGGTTTGTTCAACGGCGAAGT
GGTACTGGGCGATGAATTCTCGCCGGATGGTAGCCGCCTGTGGGACAAAAACACCCTGGACAAGATGGACAAAGACCGCT
TCCGTCAGAGCCTGGGTGGCCTGATCGAAGCCTACGAAGAAGTGGCTCGCCGCATCGGCGTCAAACTCGACTAA

Upstream 100 bases:

>100_bases
TCTTTGTTCAATACGGTATCGTTTGCGTCACGGATTTGGCACAATAGACCCCATCATCCTTGCAGCGTTTTTAAATAATT
CTTTTATTGGAGTAAGTCAG

Downstream 100 bases:

>100_bases
GCCCTTTTCCGCTATACGGGGCCGTTTGGCCCCGTCATTTCCCTGACTTTCCCCGCCGTCTGTTCCTTCTGTCTGCATTT
CCAGAAAAATTCTACATTTC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMSKLEEAGIPTQMERLLSDNEVL
VKKLDMVPVECVIRNRAAGSLVKRLGIEEGLVLNPPLFDLFLKNDEMHDPMVNESYCETFGWVNKQHLARMRELSYQAND
VLSKLFDDAGLILVDFKLEFGLFNGEVVLGDEFSPDGSRLWDKNTLDKMDKDRFRQSLGGLIEAYEEVARRIGVKLD

Sequences:

>Translated_237_residues
MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMSKLEEAGIPTQMERLLSDNEVL
VKKLDMVPVECVIRNRAAGSLVKRLGIEEGLVLNPPLFDLFLKNDEMHDPMVNESYCETFGWVNKQHLARMRELSYQAND
VLSKLFDDAGLILVDFKLEFGLFNGEVVLGDEFSPDGSRLWDKNTLDKMDKDRFRQSLGGLIEAYEEVARRIGVKLD
>Mature_237_residues
MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMSKLEEAGIPTQMERLLSDNEVL
VKKLDMVPVECVIRNRAAGSLVKRLGIEEGLVLNPPLFDLFLKNDEMHDPMVNESYCETFGWVNKQHLARMRELSYQAND
VLSKLFDDAGLILVDFKLEFGLFNGEVVLGDEFSPDGSRLWDKNTLDKMDKDRFRQSLGGLIEAYEEVARRIGVKLD

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=245, Percent_Identity=28.9795918367347, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI5453539, Length=245, Percent_Identity=28.9795918367347, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI119220559, Length=252, Percent_Identity=27.7777777777778, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1788820, Length=237, Percent_Identity=89.0295358649789, Blast_Score=438, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17531275, Length=219, Percent_Identity=26.027397260274, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI18860083, Length=221, Percent_Identity=29.8642533936652, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24583917, Length=204, Percent_Identity=30.8823529411765, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27212; Mature: 27212

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMSK
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
LEEAGIPTQMERLLSDNEVLVKKLDMVPVECVIRNRAAGSLVKRLGIEEGLVLNPPLFDL
HHHCCCCHHHHHHHCCCHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCEEECCCHHEE
FLKNDEMHDPMVNESYCETFGWVNKQHLARMRELSYQANDVLSKLFDDAGLILVDFKLEF
EECCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEEEE
GLFNGEVVLGDEFSPDGSRLWDKNTLDKMDKDRFRQSLGGLIEAYEEVARRIGVKLD
EEECCEEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMSK
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
LEEAGIPTQMERLLSDNEVLVKKLDMVPVECVIRNRAAGSLVKRLGIEEGLVLNPPLFDL
HHHCCCCHHHHHHHCCCHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCEEECCCHHEE
FLKNDEMHDPMVNESYCETFGWVNKQHLARMRELSYQANDVLSKLFDDAGLILVDFKLEF
EECCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEEEE
GLFNGEVVLGDEFSPDGSRLWDKNTLDKMDKDRFRQSLGGLIEAYEEVARRIGVKLD
EEECCEEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA