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The map label for this gene is sixA [H]

Identifier: 157371614

GI number: 157371614

Start: 3736863

End: 3737345

Strand: Reverse

Name: sixA [H]

Synonym: Spro_3377

Alternate gene names: 157371614

Gene position: 3737345-3736863 (Counterclockwise)

Preceding gene: 157371615

Following gene: 157371612

Centisome position: 68.59

GC content: 58.18

Gene sequence:

>483_bases
ATGCAAGTTTTGATTATGCGTCACGGAGAGGCGGCACTCGATGCGGCCAGCGATTCGGTAAGACCTCTTACTGTTTGTGG
CCGTGATGAGTCACGTCAGATGGCGGCCTGGTTAAATACCAAGTCTGTGGATATTGAACGAGTGCTGGTCAGCCCCTATC
TGCGGGCCGAGCAGACGCTGGCCACGGTGCGCGAAGCCTTGACCTTGCCGGCGAGCGAAGAGGTGCTGCCTGAGTTGACG
CCGGGCGGAGACGCCAGCCTGGTGGGCAGTTATTTGCAGGTGCTGGCACAGCAGGGGATCAGCTCGGTGCTGATTGTCTC
TCACTTGCCGCTGGTGGGTTACCTGGTGGCTGAGCTTTGCCCGGGTGAATGTCCACCGATGTTTGCCACCTCGGCAATCG
CCAACGTTGATTTGGCGGCAGACGGTAGCTACGGTAAATTTGAATGGCAGGTCAGTCCGTCGCAGGTGATGGCTAAAGTG
TAG

Upstream 100 bases:

>100_bases
TTATCGTTTCAAAGCTTTTGCTTTGGGGTTGTAAAACTCGGCGATACAGCACGCTCGGCGTTTCTGTATAGCGTTATTTT
GTCAACAACAGCGGTGCAAT

Downstream 100 bases:

>100_bases
GGGCCGCAGGCCGGTTCCAAACAAAAGGGCGATGTTAAATATCGCCCTTTTGTCATTTCTGCAGTTTACTCGGCCAGTTC
GACCAGCAGCAAGATGGCCG

Product: phosphohistidine phosphatase

Products: NA

Alternate protein names: RX6 [H]

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MQVLIMRHGEAALDAASDSVRPLTVCGRDESRQMAAWLNTKSVDIERVLVSPYLRAEQTLATVREALTLPASEEVLPELT
PGGDASLVGSYLQVLAQQGISSVLIVSHLPLVGYLVAELCPGECPPMFATSAIANVDLAADGSYGKFEWQVSPSQVMAKV

Sequences:

>Translated_160_residues
MQVLIMRHGEAALDAASDSVRPLTVCGRDESRQMAAWLNTKSVDIERVLVSPYLRAEQTLATVREALTLPASEEVLPELT
PGGDASLVGSYLQVLAQQGISSVLIVSHLPLVGYLVAELCPGECPPMFATSAIANVDLAADGSYGKFEWQVSPSQVMAKV
>Mature_160_residues
MQVLIMRHGEAALDAASDSVRPLTVCGRDESRQMAAWLNTKSVDIERVLVSPYLRAEQTLATVREALTLPASEEVLPELT
PGGDASLVGSYLQVLAQQGISSVLIVSHLPLVGYLVAELCPGECPPMFATSAIANVDLAADGSYGKFEWQVSPSQVMAKV

Specific function: Exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His- Asp phosphorelay [H]

COG id: COG2062

COG function: function code T; Phosphohistidine phosphatase SixA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sixA phosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788681, Length=160, Percent_Identity=68.75, Blast_Score=218, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR004449 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: 3.1.3.- [C]

Molecular weight: Translated: 17054; Mature: 17054

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVLIMRHGEAALDAASDSVRPLTVCGRDESRQMAAWLNTKSVDIERVLVSPYLRAEQTL
CEEEEEECCCHHHHCCCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ATVREALTLPASEEVLPELTPGGDASLVGSYLQVLAQQGISSVLIVSHLPLVGYLVAELC
HHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
PGECPPMFATSAIANVDLAADGSYGKFEWQVSPSQVMAKV
CCCCCCCHHHHHHHCEEEEECCCCCEEEEEECHHHHHHCC
>Mature Secondary Structure
MQVLIMRHGEAALDAASDSVRPLTVCGRDESRQMAAWLNTKSVDIERVLVSPYLRAEQTL
CEEEEEECCCHHHHCCCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ATVREALTLPASEEVLPELTPGGDASLVGSYLQVLAQQGISSVLIVSHLPLVGYLVAELC
HHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
PGECPPMFATSAIANVDLAADGSYGKFEWQVSPSQVMAKV
CCCCCCCHHHHHHHCEEEEECCCCCEEEEEECHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9489669; 9205837; 9278503 [H]