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The map label for this gene is fabB [H]

Identifier: 157371605

GI number: 157371605

Start: 3727993

End: 3729207

Strand: Reverse

Name: fabB [H]

Synonym: Spro_3368

Alternate gene names: 157371605

Gene position: 3729207-3727993 (Counterclockwise)

Preceding gene: 157371607

Following gene: 157371604

Centisome position: 68.44

GC content: 57.2

Gene sequence:

>1215_bases
ATGAAACGTGCAGTGATTACTGGCCTGGGAATCGTCTCCAGCATTGGTAACAACCAGCAGGAGGTCCTGGCGAGCCTGCA
GGAAGGACGTTCTGGGATCACTTTCTCCCAGGAACTGAAAGATTCCGGCATGCGTAGTCACGTATGGGGCGATGTTAAAC
TGGACACCACAGGTCTGATCGACCGTAAAGTGATGCGCTTTATGAGCGATGCGTCCGTTTATGCCTATCTTTCCATGGAA
GAAGCCATCAAAGACTCAGGTCTGGCTGCCGATCAGGTTTCCAACGATCGCACCGGTCTGGTAGTTGGCTCAGGTGGCGG
CTCTCCGCGCAACCAGGTTGCCGGATCCGACGGCATGCGTGCCAAAGGCCTGCGCGGCGTTGGCCCGTACATGGTGACCA
AAGCCATGGCTTCAGGCGTTTCCGCCTGCCTGGCAACCCCGTTCAAAATTCGTGGCGTTAACTATTCCATCAGCTCTGCC
TGCGCAACCTCTGCACACTGCATTGGCCACGCGGTTGAACTGATCCAACTGGGCAAGCAGGACGTAGTCTTTGCCGGCGG
CGGTGAAGAACTGTGCTGGGAAATGGCCTGTGAGTTCGATGCGATGGGCGCTCTGTCCACCAGCTACAACGACACTCCGG
AAAAAGCTTCCCGTACCTATGACGCAGCGCGTGACGGTTTCGTCATCGCCGGCGGCGGCGGTATGGTGGTAGTAGAAGAG
CTGGAACATGCTCTGGCGCGTGGCGCACACATCTACGCTGAGATCATCGGCTACGGTGCGACCTCCGACGGTGCCGATAT
GGTTGCGCCATCAGGCGAAGGCGCAGTGCGTTGCATGAAAATGGCAATGCAGGGCGTTGACACCCCAATCGACTACATGA
ACGTGCACGGGACTTCTACGCCGGTTGGCGATGTGAAAGAACTGGGCGCTATTCGTGAAGTGTTTGGTGACAACACCCCG
GCAATCTCCTCCACCAAGGCCATGACCGGTCACTCACTGGGCGCTGCCGGCGTGCAGGAAGCGATCTACAGCCTGTTGAT
GGTTGAGCACGGCTTTATTGCGCCGAGCATCAACATCGAAAACCTGGATGAGAAAGCCGCAGGCATGAACATCGTGACTC
AGCCGACTCAACGCGAGCTGACTACCGTGATGTCCAACAGCTTCGGTTTCGGCGGCACCAACGCCACGCTGGTAATGCGT
AAGCTGCAGAAGTAA

Upstream 100 bases:

>100_bases
GAATAAAGCTGAAAAACGCTGATCGGACTTGTTCGGCGTACATCTGTACGCTAAAGTGCGATGCAAAATCCCGAATGTAA
AAATGTGGAAGAGGTACTGA

Downstream 100 bases:

>100_bases
TTCCGGCTTCAAGATTGTGGATCAAGCCCGCGCTTTTCGCGGGCTTTTTAATGCCTGTCGATCCTGCCGGTTGGCCGCTC
GGAGTTATCTCAAATTACAT

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFSQELKDSGMRSHVWGDVKLDTTGLIDRKVMRFMSDASVYAYLSME
EAIKDSGLAADQVSNDRTGLVVGSGGGSPRNQVAGSDGMRAKGLRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSA
CATSAHCIGHAVELIQLGKQDVVFAGGGEELCWEMACEFDAMGALSTSYNDTPEKASRTYDAARDGFVIAGGGGMVVVEE
LEHALARGAHIYAEIIGYGATSDGADMVAPSGEGAVRCMKMAMQGVDTPIDYMNVHGTSTPVGDVKELGAIREVFGDNTP
AISSTKAMTGHSLGAAGVQEAIYSLLMVEHGFIAPSINIENLDEKAAGMNIVTQPTQRELTTVMSNSFGFGGTNATLVMR
KLQK

Sequences:

>Translated_404_residues
MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFSQELKDSGMRSHVWGDVKLDTTGLIDRKVMRFMSDASVYAYLSME
EAIKDSGLAADQVSNDRTGLVVGSGGGSPRNQVAGSDGMRAKGLRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSA
CATSAHCIGHAVELIQLGKQDVVFAGGGEELCWEMACEFDAMGALSTSYNDTPEKASRTYDAARDGFVIAGGGGMVVVEE
LEHALARGAHIYAEIIGYGATSDGADMVAPSGEGAVRCMKMAMQGVDTPIDYMNVHGTSTPVGDVKELGAIREVFGDNTP
AISSTKAMTGHSLGAAGVQEAIYSLLMVEHGFIAPSINIENLDEKAAGMNIVTQPTQRELTTVMSNSFGFGGTNATLVMR
KLQK
>Mature_404_residues
MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFSQELKDSGMRSHVWGDVKLDTTGLIDRKVMRFMSDASVYAYLSME
EAIKDSGLAADQVSNDRTGLVVGSGGGSPRNQVAGSDGMRAKGLRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSA
CATSAHCIGHAVELIQLGKQDVVFAGGGEELCWEMACEFDAMGALSTSYNDTPEKASRTYDAARDGFVIAGGGGMVVVEE
LEHALARGAHIYAEIIGYGATSDGADMVAPSGEGAVRCMKMAMQGVDTPIDYMNVHGTSTPVGDVKELGAIREVFGDNTP
AISSTKAMTGHSLGAAGVQEAIYSLLMVEHGFIAPSINIENLDEKAAGMNIVTQPTQRELTTVMSNSFGFGGTNATLVMR
KLQK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=424, Percent_Identity=35.377358490566, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI223972627, Length=170, Percent_Identity=40.5882352941176, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI41872631, Length=335, Percent_Identity=28.6567164179104, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=87.4074074074074, Blast_Score=728, Evalue=0.0,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=37.8640776699029, Blast_Score=239, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=35.0119904076739, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=39.2452830188679, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI212642053, Length=335, Percent_Identity=26.865671641791, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=357, Percent_Identity=25.7703081232493, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=29.9107142857143, Blast_Score=173, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=37.8896882494005, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI19920632, Length=336, Percent_Identity=27.0833333333333, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI221330659, Length=336, Percent_Identity=27.0833333333333, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24581345, Length=336, Percent_Identity=23.5119047619048, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42292; Mature: 42292

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFSQELKDSGMRSHVWGDVKLDTTGLI
CCCCEEEHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCHHCCCCEEECCCHHH
DRKVMRFMSDASVYAYLSMEEAIKDSGLAADQVSNDRTGLVVGSGGGSPRNQVAGSDGMR
HHHHHHHHCCCCEEEEEEHHHHHHHCCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCCCC
AKGLRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSACATSAHCIGHAVELIQLGKQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DVVFAGGGEELCWEMACEFDAMGALSTSYNDTPEKASRTYDAARDGFVIAGGGGMVVVEE
CEEEECCCHHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCEEEHHH
LEHALARGAHIYAEIIGYGATSDGADMVAPSGEGAVRCMKMAMQGVDTPIDYMNVHGTST
HHHHHHCCHHEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHEECCCCCC
PVGDVKELGAIREVFGDNTPAISSTKAMTGHSLGAAGVQEAIYSLLMVEHGFIAPSINIE
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
NLDEKAAGMNIVTQPTQRELTTVMSNSFGFGGTNATLVMRKLQK
CCCHHHCCCCEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFSQELKDSGMRSHVWGDVKLDTTGLI
CCCCEEEHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCHHCCCCEEECCCHHH
DRKVMRFMSDASVYAYLSMEEAIKDSGLAADQVSNDRTGLVVGSGGGSPRNQVAGSDGMR
HHHHHHHHCCCCEEEEEEHHHHHHHCCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCCCC
AKGLRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSACATSAHCIGHAVELIQLGKQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DVVFAGGGEELCWEMACEFDAMGALSTSYNDTPEKASRTYDAARDGFVIAGGGGMVVVEE
CEEEECCCHHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCEEEHHH
LEHALARGAHIYAEIIGYGATSDGADMVAPSGEGAVRCMKMAMQGVDTPIDYMNVHGTST
HHHHHHCCHHEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHEECCCCCC
PVGDVKELGAIREVFGDNTPAISSTKAMTGHSLGAAGVQEAIYSLLMVEHGFIAPSINIE
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
NLDEKAAGMNIVTQPTQRELTTVMSNSFGFGGTNATLVMRKLQK
CCCHHHCCCCEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]