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The map label for this gene is hisQ [H]

Identifier: 157371562

GI number: 157371562

Start: 3680580

End: 3681266

Strand: Reverse

Name: hisQ [H]

Synonym: Spro_3325

Alternate gene names: 157371562

Gene position: 3681266-3680580 (Counterclockwise)

Preceding gene: 157371563

Following gene: 157371561

Centisome position: 67.56

GC content: 55.46

Gene sequence:

>687_bases
ATGCTGCAAGGCTATTCCCAATTGATATTAGAGGGGGCTCTGGTGACGCTGGAGCTGGCCCTCAGTTCCGTACTGCTGGC
GCTGGTCATCGGTTTGATCGGTGCCGGCGGCAAGCTTTCCCAAAATCGCCTGCTTTCTACCGTGTTTGGCGCTTATACCA
CGCTGATCCGTGGCGTACCCGATCTGGTGCTGATGCTGCTGATTTTCTATGGCCTGCAAATTGCGCTCAACAACCTCACC
GAACTGCTTGGCTTCGCGCAAATCGATATTGATCCGCTCAGCGCGGGCATAATCACCCTCGGGTTTATCTACGGCGCTTA
TTTCACTGAAACCTTTCGCGGTGCCTATATGGCGGTGTCGAAGGGGCAGATTGAAGCGGCAACGGCCTACGGTTTCACCG
GTTCACAAATTTTCCGCCGCATTCTGTTCCCTGCGATGATGCGTTTTGCCCTGCCGGGCATTGGCAACAACTGGCAGGTG
ATCCTGAAGGCCACGGCGCTGGTGTCTATTCTGGGCCTCAATGACGTGGTGAAAGCCACTCAGTTGGCCGGCAAAGGCAC
CTATCAGCCGTTCTTCTTTGCGATCGTGGCCGGTGTGGTTTATCTGGTTTTCACAACCGTTTCCAATGGTGTGCTGCTGT
GGCTTGAACGGCGTTATTCCCTGGGCGTCCGGAGGGCTGAGCTATGA

Upstream 100 bases:

>100_bases
GTCTACGGCGGTTAATGCCGCTTACCGTTCCATGTTGTGACTACGGGGCTGGCCCGCCGGCCCCGATGGTTCGGGATCCA
ATGACGACAGGGTGAAGTAA

Downstream 100 bases:

>100_bases
TCGAGATTTTACAACAGTACTGGCAATCGCTGCTGTGGAGCGACGGTTACCGTTTCACCGGGGTCGCCGTTACCCTGTGG
CTGCTGATTTCCTCGGTAGT

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MLQGYSQLILEGALVTLELALSSVLLALVIGLIGAGGKLSQNRLLSTVFGAYTTLIRGVPDLVLMLLIFYGLQIALNNLT
ELLGFAQIDIDPLSAGIITLGFIYGAYFTETFRGAYMAVSKGQIEAATAYGFTGSQIFRRILFPAMMRFALPGIGNNWQV
ILKATALVSILGLNDVVKATQLAGKGTYQPFFFAIVAGVVYLVFTTVSNGVLLWLERRYSLGVRRAEL

Sequences:

>Translated_228_residues
MLQGYSQLILEGALVTLELALSSVLLALVIGLIGAGGKLSQNRLLSTVFGAYTTLIRGVPDLVLMLLIFYGLQIALNNLT
ELLGFAQIDIDPLSAGIITLGFIYGAYFTETFRGAYMAVSKGQIEAATAYGFTGSQIFRRILFPAMMRFALPGIGNNWQV
ILKATALVSILGLNDVVKATQLAGKGTYQPFFFAIVAGVVYLVFTTVSNGVLLWLERRYSLGVRRAEL
>Mature_228_residues
MLQGYSQLILEGALVTLELALSSVLLALVIGLIGAGGKLSQNRLLSTVFGAYTTLIRGVPDLVLMLLIFYGLQIALNNLT
ELLGFAQIDIDPLSAGIITLGFIYGAYFTETFRGAYMAVSKGQIEAATAYGFTGSQIFRRILFPAMMRFALPGIGNNWQV
ILKATALVSILGLNDVVKATQLAGKGTYQPFFFAIVAGVVYLVFTTVSNGVLLWLERRYSLGVRRAEL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=228, Percent_Identity=79.8245614035088, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1787087, Length=226, Percent_Identity=35.3982300884956, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1787030, Length=214, Percent_Identity=29.9065420560748, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788645, Length=215, Percent_Identity=33.0232558139535, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788226, Length=199, Percent_Identity=30.1507537688442, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786873, Length=210, Percent_Identity=27.1428571428571, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787086, Length=220, Percent_Identity=28.6363636363636, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786874, Length=182, Percent_Identity=29.6703296703297, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24642; Mature: 24642

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQGYSQLILEGALVTLELALSSVLLALVIGLIGAGGKLSQNRLLSTVFGAYTTLIRGVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCH
DLVLMLLIFYGLQIALNNLTELLGFAQIDIDPLSAGIITLGFIYGAYFTETFRGAYMAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEC
KGQIEAATAYGFTGSQIFRRILFPAMMRFALPGIGNNWQVILKATALVSILGLNDVVKAT
CCCEEEHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAGKGTYQPFFFAIVAGVVYLVFTTVSNGVLLWLERRYSLGVRRAEL
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCHHCCC
>Mature Secondary Structure
MLQGYSQLILEGALVTLELALSSVLLALVIGLIGAGGKLSQNRLLSTVFGAYTTLIRGVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCH
DLVLMLLIFYGLQIALNNLTELLGFAQIDIDPLSAGIITLGFIYGAYFTETFRGAYMAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEC
KGQIEAATAYGFTGSQIFRRILFPAMMRFALPGIGNNWQVILKATALVSILGLNDVVKAT
CCCEEEHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAGKGTYQPFFFAIVAGVVYLVFTTVSNGVLLWLERRYSLGVRRAEL
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]