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The map label for this gene is livH [H]

Identifier: 157371439

GI number: 157371439

Start: 3525947

End: 3526963

Strand: Reverse

Name: livH [H]

Synonym: Spro_3202

Alternate gene names: 157371439

Gene position: 3526963-3525947 (Counterclockwise)

Preceding gene: 157371440

Following gene: 157371438

Centisome position: 64.73

GC content: 59.0

Gene sequence:

>1017_bases
ATGACTGACAAGCGGATCCGCGTGTTCGGCGGATCCGCGCCGATACTTCCCTTGGGCCGCGTCTGCACTAGCTTGCGGTC
CCACCAGGCGAGACTGCTCATTATGGATGTTTTCTTTCTGCAACAGTTGATCAACGGCCTGACGCTCGGCGCGGTTTACG
GCCTGATCGCCATCGGCTACACCATGGTTTACGGCATTATCGGCATGATTAACTTCGCCCACGGCGAGGTGTACATGATC
TCCGCCTACCTGTGCGCCATCGGGCTGGCGCTGCTGTCGTTCTTCGGCCTGCAATCCTTTCCGCTGCTGATCCTCGGCAC
GTTGGTGTTTACCATCGTCGTCACCGGGGTGTATGGCTGGGTGATAGAGCGGATCGCCTACAAACCCTTGCGCAATTCCA
CTCGTCTGGCACCGCTGATCTCCGCCATCGGCATGTCGCTCATTTTGCAAAACTACGCGCAAATCAGCCAGGGGCCGCGC
CAGCAAGGGATCCCGACCTTGCTGGACGGCGTGTTCCGCCTCAACTTTGACGGTGGGGTGATCCAAATCACCTACACCAA
GGTGTTTATCCTGGTCGCCTCACTGCTGGGCATGGCCATCCTCACTTACATCATTCAGCACACCCGTCTGGGGCGTATCT
GCCGCGCCACCCAGCAGGATCGCAAGATGGCGTCCATTCTGGGCATCAATACCGACCGGGTGATCTCCCTGGTGTTCGTG
ATTGGTGCCGCGATGGCCGGGCTGGCGGGGGTGTTGATCACCATGAACTACGGCACCTTTGATTTCTACGTCGGCTTTAT
TATCGGCATCAAGGCTTTTACCGCCGCGGTGCTGGGGGGCATTGGTTCGTTACCCGGCGCGATGCTGGGCGGGCTGCTGC
TGGGCGTCGCGGAGGCGCAGTTTGCCGGCATGGTGAACTCCGATTACAAAGACGTATTCTCCTTCGGTTTGCTGGTGGTG
ATCCTGATTTTCCGCCCTCAGGGCCTGCTCGGTCGGCCAATGGTCGCTAAGGTTTGA

Upstream 100 bases:

>100_bases
GGATTACGTGGTCTATCAATGGGACGATAAAGGCAAATATCACCAACTCTAATCAGCCCGAAGGCTCAGGTTTATCCCGC
CCACAGGGTGCTGGATTGAC

Downstream 100 bases:

>100_bases
GGGGAAAACTATGTCGCAATCTATGGTTCACCCAGGGCTGAACGTTAAACGCAGCCTGCTGGATGCGGTGCTGGCCGGGC
TGATCGCCCTGATCGTCTTC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MTDKRIRVFGGSAPILPLGRVCTSLRSHQARLLIMDVFFLQQLINGLTLGAVYGLIAIGYTMVYGIIGMINFAHGEVYMI
SAYLCAIGLALLSFFGLQSFPLLILGTLVFTIVVTGVYGWVIERIAYKPLRNSTRLAPLISAIGMSLILQNYAQISQGPR
QQGIPTLLDGVFRLNFDGGVIQITYTKVFILVASLLGMAILTYIIQHTRLGRICRATQQDRKMASILGINTDRVISLVFV
IGAAMAGLAGVLITMNYGTFDFYVGFIIGIKAFTAAVLGGIGSLPGAMLGGLLLGVAEAQFAGMVNSDYKDVFSFGLLVV
ILIFRPQGLLGRPMVAKV

Sequences:

>Translated_338_residues
MTDKRIRVFGGSAPILPLGRVCTSLRSHQARLLIMDVFFLQQLINGLTLGAVYGLIAIGYTMVYGIIGMINFAHGEVYMI
SAYLCAIGLALLSFFGLQSFPLLILGTLVFTIVVTGVYGWVIERIAYKPLRNSTRLAPLISAIGMSLILQNYAQISQGPR
QQGIPTLLDGVFRLNFDGGVIQITYTKVFILVASLLGMAILTYIIQHTRLGRICRATQQDRKMASILGINTDRVISLVFV
IGAAMAGLAGVLITMNYGTFDFYVGFIIGIKAFTAAVLGGIGSLPGAMLGGLLLGVAEAQFAGMVNSDYKDVFSFGLLVV
ILIFRPQGLLGRPMVAKV
>Mature_337_residues
TDKRIRVFGGSAPILPLGRVCTSLRSHQARLLIMDVFFLQQLINGLTLGAVYGLIAIGYTMVYGIIGMINFAHGEVYMIS
AYLCAIGLALLSFFGLQSFPLLILGTLVFTIVVTGVYGWVIERIAYKPLRNSTRLAPLISAIGMSLILQNYAQISQGPRQ
QGIPTLLDGVFRLNFDGGVIQITYTKVFILVASLLGMAILTYIIQHTRLGRICRATQQDRKMASILGINTDRVISLVFVI
GAAMAGLAGVLITMNYGTFDFYVGFIIGIKAFTAAVLGGIGSLPGAMLGGLLLGVAEAQFAGMVNSDYKDVFSFGLLVVI
LIFRPQGLLGRPMVAKV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=306, Percent_Identity=54.9019607843137, Blast_Score=309, Evalue=1e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 36414; Mature: 36283

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKRIRVFGGSAPILPLGRVCTSLRSHQARLLIMDVFFLQQLINGLTLGAVYGLIAIGY
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMVYGIIGMINFAHGEVYMISAYLCAIGLALLSFFGLQSFPLLILGTLVFTIVVTGVYGW
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VIERIAYKPLRNSTRLAPLISAIGMSLILQNYAQISQGPRQQGIPTLLDGVFRLNFDGGV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEECCCCE
IQITYTKVFILVASLLGMAILTYIIQHTRLGRICRATQQDRKMASILGINTDRVISLVFV
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IGAAMAGLAGVLITMNYGTFDFYVGFIIGIKAFTAAVLGGIGSLPGAMLGGLLLGVAEAQ
HHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FAGMVNSDYKDVFSFGLLVVILIFRPQGLLGRPMVAKV
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDKRIRVFGGSAPILPLGRVCTSLRSHQARLLIMDVFFLQQLINGLTLGAVYGLIAIGY
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMVYGIIGMINFAHGEVYMISAYLCAIGLALLSFFGLQSFPLLILGTLVFTIVVTGVYGW
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VIERIAYKPLRNSTRLAPLISAIGMSLILQNYAQISQGPRQQGIPTLLDGVFRLNFDGGV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEECCCCE
IQITYTKVFILVASLLGMAILTYIIQHTRLGRICRATQQDRKMASILGINTDRVISLVFV
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IGAAMAGLAGVLITMNYGTFDFYVGFIIGIKAFTAAVLGGIGSLPGAMLGGLLLGVAEAQ
HHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FAGMVNSDYKDVFSFGLLVVILIFRPQGLLGRPMVAKV
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]