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The map label for this gene is qor [C]

Identifier: 157371421

GI number: 157371421

Start: 3503358

End: 3504377

Strand: Reverse

Name: qor [C]

Synonym: Spro_3182

Alternate gene names: 157371421

Gene position: 3504377-3503358 (Counterclockwise)

Preceding gene: 157371422

Following gene: 157371420

Centisome position: 64.31

GC content: 48.43

Gene sequence:

>1020_bases
ATGAATAATAAGACGATGAAAGCCTTCACGTTTAAGCGTTACGGTAAATCTCCTGAATTAGGGTTTGATAACGTAGATTA
TCCTTCGCTCAAGGCTAATGAAGTCTTGGTTAAAGTTTACGCTGTGGGCCTAAATCCAATCGACAATATGATCCCAACCG
GAATATTTAAGCCGGTTCTGCATTTTAAGCTTCCCGCAACATTGGGTAGCGATCTGTCTGGGGTTGTTATTGCCGTGGGA
AGTCGCGTGACTCGTTTTTCCCCAGGCGATGAAATCTTCGCCAGCATCTTCGATACGGGAACGGGGTCTCTTGCCGAATT
TGCCGTGGTGCCTGAGAGCGCTGCGGCTATAAAACCGGCAAATCTGGATTTTGTGCAGGCGGCTTCGCTCCCTATGGTTA
GCCTCACGTCCTGGCAGGCTCTGACAGAGCGTGTCAGGCTACGGCCTGGTCAGAAGGTTTTCATCCCGGCAGGTTCTGGA
GGGATAGGCACCTTTGCTATCCAACTGGCGAAGCAATTGGGCGCAACCGTGGGGACGACAACCAGTACGGGCAATATCGA
ATGGGTGAGGAGCCTGGGGGCTGACGAAGTCGTTGACTATAAAAAAGAAGAGTTCGAAAAAGTATTGGCTGGCTATGATG
TGGTACTTGGCACCACCAGGGGAGATATGATTGAAAAATCCACCCAGATCCTTAAGCCTGGAGGAAGTATTGTTTCTCTC
GTCGGGCCGTTAGATGTCAAATTTGCGCGGGCTAGAGGGTTAAATTTCTTTCTGACTTTTATCTTCAGGCTTATGAGCCG
CAATATTATGCGTCTTTCAAAAAAGCGGGGCTTGACCTATACGTTTCTATTCGTTCGGCCAGAAGGTGATCAACTCAGCC
AGATAGGTAAACTGGTAGAAACCGAACAAATCAAACCCATGATCGACAAGGTATTCCCCTTTGCTCAAACAAAGGAGGCT
CTTGCCTACCTTGCCCAGGGGCATGCAAAGGGAAAAGTGGTTATCAAGATGCAGGATTAA

Upstream 100 bases:

>100_bases
CAAACAAGATGAAGCCGCAGAGCGATATAAAACCCTTTAGACAATAAAGGGTCCTGCTCAGAACAATCGTTCAGCTGCCT
GCACGGCAGGGGAAAAATAA

Downstream 100 bases:

>100_bases
TTCCTTATTCTATGCTGCCGTGTTGCCGTTGTCGGATAAGTGGCTATCATCTTTCCTTTAAACCCTTGCCGCTGCCGAAA
GGATTGCCTGCCACTATGCC

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MNNKTMKAFTFKRYGKSPELGFDNVDYPSLKANEVLVKVYAVGLNPIDNMIPTGIFKPVLHFKLPATLGSDLSGVVIAVG
SRVTRFSPGDEIFASIFDTGTGSLAEFAVVPESAAAIKPANLDFVQAASLPMVSLTSWQALTERVRLRPGQKVFIPAGSG
GIGTFAIQLAKQLGATVGTTTSTGNIEWVRSLGADEVVDYKKEEFEKVLAGYDVVLGTTRGDMIEKSTQILKPGGSIVSL
VGPLDVKFARARGLNFFLTFIFRLMSRNIMRLSKKRGLTYTFLFVRPEGDQLSQIGKLVETEQIKPMIDKVFPFAQTKEA
LAYLAQGHAKGKVVIKMQD

Sequences:

>Translated_339_residues
MNNKTMKAFTFKRYGKSPELGFDNVDYPSLKANEVLVKVYAVGLNPIDNMIPTGIFKPVLHFKLPATLGSDLSGVVIAVG
SRVTRFSPGDEIFASIFDTGTGSLAEFAVVPESAAAIKPANLDFVQAASLPMVSLTSWQALTERVRLRPGQKVFIPAGSG
GIGTFAIQLAKQLGATVGTTTSTGNIEWVRSLGADEVVDYKKEEFEKVLAGYDVVLGTTRGDMIEKSTQILKPGGSIVSL
VGPLDVKFARARGLNFFLTFIFRLMSRNIMRLSKKRGLTYTFLFVRPEGDQLSQIGKLVETEQIKPMIDKVFPFAQTKEA
LAYLAQGHAKGKVVIKMQD
>Mature_339_residues
MNNKTMKAFTFKRYGKSPELGFDNVDYPSLKANEVLVKVYAVGLNPIDNMIPTGIFKPVLHFKLPATLGSDLSGVVIAVG
SRVTRFSPGDEIFASIFDTGTGSLAEFAVVPESAAAIKPANLDFVQAASLPMVSLTSWQALTERVRLRPGQKVFIPAGSG
GIGTFAIQLAKQLGATVGTTTSTGNIEWVRSLGADEVVDYKKEEFEKVLAGYDVVLGTTRGDMIEKSTQILKPGGSIVSL
VGPLDVKFARARGLNFFLTFIFRLMSRNIMRLSKKRGLTYTFLFVRPEGDQLSQIGKLVETEQIKPMIDKVFPFAQTKEA
LAYLAQGHAKGKVVIKMQD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=359, Percent_Identity=36.2116991643454, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI194239674, Length=349, Percent_Identity=27.7936962750716, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI13236495, Length=349, Percent_Identity=27.7936962750716, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI194239676, Length=207, Percent_Identity=31.8840579710145, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI22538446, Length=349, Percent_Identity=28.6532951289398, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI22538444, Length=349, Percent_Identity=28.6532951289398, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI18379349, Length=315, Percent_Identity=28.2539682539683, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI24308257, Length=349, Percent_Identity=25.214899713467, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI28557745, Length=216, Percent_Identity=31.0185185185185, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI41872631, Length=324, Percent_Identity=26.5432098765432, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI67078404, Length=210, Percent_Identity=29.5238095238095, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI90669511, Length=185, Percent_Identity=29.7297297297297, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1790485, Length=215, Percent_Identity=30.2325581395349, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71987554, Length=342, Percent_Identity=30.1169590643275, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17507255, Length=202, Percent_Identity=30.6930693069307, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319520, Length=336, Percent_Identity=25.8928571428571, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=272, Percent_Identity=27.9411764705882, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=275, Percent_Identity=28.3636363636364, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581339, Length=366, Percent_Identity=29.5081967213115, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24581341, Length=366, Percent_Identity=29.5081967213115, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI19920632, Length=250, Percent_Identity=24.8, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330659, Length=250, Percent_Identity=24.8, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36893; Mature: 36893

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKTMKAFTFKRYGKSPELGFDNVDYPSLKANEVLVKVYAVGLNPIDNMIPTGIFKPVL
CCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHCCHHHHHHHH
HFKLPATLGSDLSGVVIAVGSRVTRFSPGDEIFASIFDTGTGSLAEFAVVPESAAAIKPA
HEECCHHHCCCCCCEEEEECCCEEECCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCC
NLDFVQAASLPMVSLTSWQALTERVRLRPGQKVFIPAGSGGIGTFAIQLAKQLGATVGTT
CCCHHHHCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCC
TSTGNIEWVRSLGADEVVDYKKEEFEKVLAGYDVVLGTTRGDMIEKSTQILKPGGSIVSL
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCEEEE
VGPLDVKFARARGLNFFLTFIFRLMSRNIMRLSKKRGLTYTFLFVRPEGDQLSQIGKLVE
ECCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHH
TEQIKPMIDKVFPFAQTKEALAYLAQGHAKGKVVIKMQD
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MNNKTMKAFTFKRYGKSPELGFDNVDYPSLKANEVLVKVYAVGLNPIDNMIPTGIFKPVL
CCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHCCHHHHHHHH
HFKLPATLGSDLSGVVIAVGSRVTRFSPGDEIFASIFDTGTGSLAEFAVVPESAAAIKPA
HEECCHHHCCCCCCEEEEECCCEEECCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCC
NLDFVQAASLPMVSLTSWQALTERVRLRPGQKVFIPAGSGGIGTFAIQLAKQLGATVGTT
CCCHHHHCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCC
TSTGNIEWVRSLGADEVVDYKKEEFEKVLAGYDVVLGTTRGDMIEKSTQILKPGGSIVSL
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCEEEE
VGPLDVKFARARGLNFFLTFIFRLMSRNIMRLSKKRGLTYTFLFVRPEGDQLSQIGKLVE
ECCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHH
TEQIKPMIDKVFPFAQTKEALAYLAQGHAKGKVVIKMQD
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA