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The map label for this gene is kynA

Identifier: 157371262

GI number: 157371262

Start: 3326104

End: 3326946

Strand: Reverse

Name: kynA

Synonym: Spro_3022

Alternate gene names: 157371262

Gene position: 3326946-3326104 (Counterclockwise)

Preceding gene: 157371263

Following gene: 157371261

Centisome position: 61.06

GC content: 53.86

Gene sequence:

>843_bases
ATGAACAAACGGGAATTAGAAAGCGCGATTGTCACCGATTTTTCCAAACGTATGAGCTACGGCGACTATCTGTGCCTGGA
TCAACTGCTGGACTGCCAACATCCGTTGTCCAACCCGCAGCATCATGATGAGATGCTGTTTGTGGTGCAGCACCAGACCT
CCGAACTGTGGATGAAGTTAATGCTGCATGAGCTGCAGGCGGCGCGGATACTGGTGCAGCAGGACAAACTCAGCCACTGC
TTTAAAATCCTGGCCCGGGTCAAACAGATCCAGCGTTTGCTGTTTGAGCAGTGGGCGGTGCTGGAAACCCTGACACCGTC
GGAATACGTTGAATTCCGTGACGTGCTGGGCAACTCATCGGGTTTCCAATCCCATCAATATCGCTCGATTGAATTTTTGT
TGGGCAACAAGAATGCAGCCATGCTGGCGGTATTCAGCAACGATGCGGATAAACACGCCGCGCTGAAGGCGATCCTCGAG
GCACCCAGCCTGTACGATGAATACCTGCTCTATCTGTCACGTCACGGCCTGCCGATTCCGCAGGAGTGTATCGAACGTGA
CTGGACCCAGCCTTACCAGCGCAACCCGGACCTGCTGCCGGCGTTTAAAGAGATCTACGACCACCCGCAAAAGTATTGGG
AAGCCTATGAAATGGCCGAGAAGCTGGTGGATATTGAGGAGAGCTTCCACCTGTGGCGTTTCCGCCATATGAAAACGGTG
GAGCGGATTATCGGCTTTAAAACCGGCACCGGCGGTTCCAGCGGTGTCAGCTTCCTGAAAAAGGCGCTGGAATTGACCTT
CTTCCCGGAACTGCTGGATGTGCGAACCGAGATTGGTGCCTGA

Upstream 100 bases:

>100_bases
TCTGGTTGATAGTCCTTCAGGGCGGGGGGTTGTGTACTATGTTTTCTGTTTGCAGCACGCTACACGCCGCTTCCGGTCGT
GAGCGCAGCGGAGAGAACAG

Downstream 100 bases:

>100_bases
ACGGTATCCCGTATTAGTGCGAGGAGAGGGCGATGACGGTAAGAATTGAAGATAAATCAGCGGAAAGAGTGGTGGGTGTG
CGAGTGGTCGGGCCTTATCC

Product: tryptophan 23-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNKRELESAIVTDFSKRMSYGDYLCLDQLLDCQHPLSNPQHHDEMLFVVQHQTSELWMKLMLHELQAARILVQQDKLSHC
FKILARVKQIQRLLFEQWAVLETLTPSEYVEFRDVLGNSSGFQSHQYRSIEFLLGNKNAAMLAVFSNDADKHAALKAILE
APSLYDEYLLYLSRHGLPIPQECIERDWTQPYQRNPDLLPAFKEIYDHPQKYWEAYEMAEKLVDIEESFHLWRFRHMKTV
ERIIGFKTGTGGSSGVSFLKKALELTFFPELLDVRTEIGA

Sequences:

>Translated_280_residues
MNKRELESAIVTDFSKRMSYGDYLCLDQLLDCQHPLSNPQHHDEMLFVVQHQTSELWMKLMLHELQAARILVQQDKLSHC
FKILARVKQIQRLLFEQWAVLETLTPSEYVEFRDVLGNSSGFQSHQYRSIEFLLGNKNAAMLAVFSNDADKHAALKAILE
APSLYDEYLLYLSRHGLPIPQECIERDWTQPYQRNPDLLPAFKEIYDHPQKYWEAYEMAEKLVDIEESFHLWRFRHMKTV
ERIIGFKTGTGGSSGVSFLKKALELTFFPELLDVRTEIGA
>Mature_280_residues
MNKRELESAIVTDFSKRMSYGDYLCLDQLLDCQHPLSNPQHHDEMLFVVQHQTSELWMKLMLHELQAARILVQQDKLSHC
FKILARVKQIQRLLFEQWAVLETLTPSEYVEFRDVLGNSSGFQSHQYRSIEFLLGNKNAAMLAVFSNDADKHAALKAILE
APSLYDEYLLYLSRHGLPIPQECIERDWTQPYQRNPDLLPAFKEIYDHPQKYWEAYEMAEKLVDIEESFHLWRFRHMKTV
ERIIGFKTGTGGSSGVSFLKKALELTFFPELLDVRTEIGA

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family

Homologues:

Organism=Homo sapiens, GI5032165, Length=125, Percent_Identity=37.6, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17552370, Length=320, Percent_Identity=27.8125, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32564651, Length=125, Percent_Identity=37.6, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17530891, Length=124, Percent_Identity=42.741935483871, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): T23O_SERP5 (A8GG83)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001479251.1
- ProteinModelPortal:   A8GG83
- SMR:   A8GG83
- STRING:   A8GG83
- GeneID:   5604053
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3022
- eggNOG:   COG3483
- HOGENOM:   HBG647485
- OMA:   QWSVLAT
- ProtClustDB:   CLSK2794470
- BioCyc:   SPRO399741:SPRO_3022-MONOMER
- InterPro:   IPR017485
- InterPro:   IPR004981
- PANTHER:   PTHR10138
- TIGRFAMs:   TIGR03036

Pfam domain/function: PF03301 Trp_dioxygenase

EC number: =1.13.11.11

Molecular weight: Translated: 32713; Mature: 32713

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: BINDING 109-109 BINDING 113-113 BINDING 120-120 BINDING 250-250

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRELESAIVTDFSKRMSYGDYLCLDQLLDCQHPLSNPQHHDEMLFVVQHQTSELWMKL
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHH
MLHELQAARILVQQDKLSHCFKILARVKQIQRLLFEQWAVLETLTPSEYVEFRDVLGNSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
GFQSHQYRSIEFLLGNKNAAMLAVFSNDADKHAALKAILEAPSLYDEYLLYLSRHGLPIP
CCCCHHHCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
QECIERDWTQPYQRNPDLLPAFKEIYDHPQKYWEAYEMAEKLVDIEESFHLWRFRHMKTV
HHHHHCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERIIGFKTGTGGSSGVSFLKKALELTFFPELLDVRTEIGA
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKRELESAIVTDFSKRMSYGDYLCLDQLLDCQHPLSNPQHHDEMLFVVQHQTSELWMKL
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHH
MLHELQAARILVQQDKLSHCFKILARVKQIQRLLFEQWAVLETLTPSEYVEFRDVLGNSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
GFQSHQYRSIEFLLGNKNAAMLAVFSNDADKHAALKAILEAPSLYDEYLLYLSRHGLPIP
CCCCHHHCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
QECIERDWTQPYQRNPDLLPAFKEIYDHPQKYWEAYEMAEKLVDIEESFHLWRFRHMKTV
HHHHHCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERIIGFKTGTGGSSGVSFLKKALELTFFPELLDVRTEIGA
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA