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The map label for this gene is gyrI [H]

Identifier: 157371261

GI number: 157371261

Start: 3325601

End: 3326071

Strand: Reverse

Name: gyrI [H]

Synonym: Spro_3021

Alternate gene names: 157371261

Gene position: 3326071-3325601 (Counterclockwise)

Preceding gene: 157371262

Following gene: 157371233

Centisome position: 61.04

GC content: 57.11

Gene sequence:

>471_bases
ATGACGGTAAGAATTGAAGATAAATCAGCGGAAAGAGTGGTGGGTGTGCGAGTGGTCGGGCCTTATCCGCAAACCATCCC
TCAGGGCTGCCAACGGCTGATGGCCTGGCAGCAGCAACACCAGGTGCCACTGGGGAAGTGGCTGGTGCTGTACTGGGACG
ATCCGGCTGAAGTGGCGCCCGAGCGACTGCGGGCCGATGTGGTGTTTACCGTGGCGGATGATTTCGTATTGCCGACGTCG
GGCAGTGAGGGTTTTGCGTTACAAACCCTGCCCGCCGGGCAATATGCGATTTACAACGTGCGCGTCAGCGACGGGGATTT
CGAGCGGGTATGGGGTGATTTCTATCAGCGGGAACTGCCGGCCAGCGGCTATCAGCCAGTAGAAGGGGTGAGCTATGAGC
ACTACCTTAATGACTGCGAGGCGGATGGTTACTTTGACCTGGATATTTACCAGACGGTGAAAAAAGGCTGA

Upstream 100 bases:

>100_bases
TGAAAAAGGCGCTGGAATTGACCTTCTTCCCGGAACTGCTGGATGTGCGAACCGAGATTGGTGCCTGAACGGTATCCCGT
ATTAGTGCGAGGAGAGGGCG

Downstream 100 bases:

>100_bases
GTTTGCGGTGCAGGGAAGGGAAAATGCTGAGGCGTCAGGGAGAGAAAAGGGGCTGAACCCGGCGAATACCGGGCTCAGCT
CTCTTATTATCGGCTAGAAG

Product: DNA gyrase inhibitor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MTVRIEDKSAERVVGVRVVGPYPQTIPQGCQRLMAWQQQHQVPLGKWLVLYWDDPAEVAPERLRADVVFTVADDFVLPTS
GSEGFALQTLPAGQYAIYNVRVSDGDFERVWGDFYQRELPASGYQPVEGVSYEHYLNDCEADGYFDLDIYQTVKKG

Sequences:

>Translated_156_residues
MTVRIEDKSAERVVGVRVVGPYPQTIPQGCQRLMAWQQQHQVPLGKWLVLYWDDPAEVAPERLRADVVFTVADDFVLPTS
GSEGFALQTLPAGQYAIYNVRVSDGDFERVWGDFYQRELPASGYQPVEGVSYEHYLNDCEADGYFDLDIYQTVKKG
>Mature_155_residues
TVRIEDKSAERVVGVRVVGPYPQTIPQGCQRLMAWQQQHQVPLGKWLVLYWDDPAEVAPERLRADVVFTVADDFVLPTSG
SEGFALQTLPAGQYAIYNVRVSDGDFERVWGDFYQRELPASGYQPVEGVSYEHYLNDCEADGYFDLDIYQTVKKG

Specific function: Inhibits the supercoiling activity of DNA gyrase. Protects cells from the DNA replication inhibitor microcin B17 (MccB17). Blocks MccB17 export from producing cells [H]

COG id: COG3449

COG function: function code L; DNA gyrase inhibitor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788319, Length=154, Percent_Identity=35.7142857142857, Blast_Score=106, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010499
- InterPro:   IPR011256 [H]

Pfam domain/function: PF06445 AraC_E_bind [H]

EC number: NA

Molecular weight: Translated: 17697; Mature: 17566

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRIEDKSAERVVGVRVVGPYPQTIPQGCQRLMAWQQQHQVPLGKWLVLYWDDPAEVAP
CEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHCH
ERLRADVVFTVADDFVLPTSGSEGFALQTLPAGQYAIYNVRVSDGDFERVWGDFYQRELP
HHHCEEEEEEEECCEEEECCCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCC
ASGYQPVEGVSYEHYLNDCEADGYFDLDIYQTVKKG
CCCCCCCCCCCHHHHHCCCCCCCEEEHHHHHHHHCC
>Mature Secondary Structure 
TVRIEDKSAERVVGVRVVGPYPQTIPQGCQRLMAWQQQHQVPLGKWLVLYWDDPAEVAP
EEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHCH
ERLRADVVFTVADDFVLPTSGSEGFALQTLPAGQYAIYNVRVSDGDFERVWGDFYQRELP
HHHCEEEEEEEECCEEEECCCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCC
ASGYQPVEGVSYEHYLNDCEADGYFDLDIYQTVKKG
CCCCCCCCCCCHHHHHCCCCCCCEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]