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The map label for this gene is hexR [H]

Identifier: 157371009

GI number: 157371009

Start: 3048963

End: 3049835

Strand: Direct

Name: hexR [H]

Synonym: Spro_2769

Alternate gene names: 157371009

Gene position: 3048963-3049835 (Clockwise)

Preceding gene: 157371004

Following gene: 157371010

Centisome position: 55.96

GC content: 51.43

Gene sequence:

>873_bases
ATGAATACGCTGGAAAAAATCCAGAGCCATCTGGAGCTACTGAGCAAATCTGAACGGAAAGTCGCCGAGGTGATCCTCGC
CTCCCCGCAGACCGCCATTCACTCAAGTATCGCGACGCTGGCCAGGATGGCGGACGTTAGCGAGCCCACCGTCAACCGCT
TTTGTCGCCGTCTCGATACCAAGGGTTTTCCCGATTTTAAACTGCATCTTGCCCAAAGCCTGGCCAACGGCACCCCGTAC
GTAAACCGTAACGTGGAGGAAGATGACAGCGTTGCTTCCTATACCGGTAAAATTTTCGAATCCGTCATGGCCAGCCTTGA
TACAGTAAAGGCAAATTTGGATATTGCAGCAATCAATCGTGCGGTTGACTTGCTTACCCAGGCAAAAAAAATCTCTTTCT
TCGGTTTGGGTGCCTCGGCGGCAGTGGCCCACGACGCGATGAACAAATTTTTCCGCTTTAATATTCCGGTGGTCTATTTC
GATGACATCGTCATGCAACGCATGGGATGCATGAACTCCAGCGAGGGGGATGTGGTAGTACTCATCTCCCATACCGGTCG
CACCAAAAACCTGGTGGAGATGGCGCAACTGGCACGTGAAAACGATGCCACGGTAATAGCCATTACCTCGCGCGATACCC
CACTGGCTCATGAAGCCACGCTGGCATTATTGCTCGATGTTCCGGAAGATACCGACGTTTATATGCCGATGGTATCGCGA
ATTGCGCAATTAACACTCATCGACGTGCTGGCCACCGGATTTACCTTGCGTAGAGGGGCCAAATTCAGAGATAACTTGAA
GCGGGTCAAGGAAGCGTTGAAAGAATCGCGCTTTGATAAGGGTGTGGTTATCCCCAACAGTTTCGACTCGTAA

Upstream 100 bases:

>100_bases
ACACTGCCAACGGTTACCAGCACGTAGTATATTTTCACTAAACCGGCATTGATTTCTCCTTTGATTGAAATCGACAAAAC
CCATGAGTGACTCTCGTTAT

Downstream 100 bases:

>100_bases
CCTATGTGAAAAAAACTGTCGTTCAAACTCATCTGGACGGCAGCATTAGAGGCAGTACCCTGTAATACGCTCATGCGGGT
AACCCGGGTGAAATATCAGT

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MNTLEKIQSHLELLSKSERKVAEVILASPQTAIHSSIATLARMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEDDSVASYTGKIFESVMASLDTVKANLDIAAINRAVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYF
DDIVMQRMGCMNSSEGDVVVLISHTGRTKNLVEMAQLARENDATVIAITSRDTPLAHEATLALLLDVPEDTDVYMPMVSR
IAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKGVVIPNSFDS

Sequences:

>Translated_290_residues
MNTLEKIQSHLELLSKSERKVAEVILASPQTAIHSSIATLARMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEDDSVASYTGKIFESVMASLDTVKANLDIAAINRAVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYF
DDIVMQRMGCMNSSEGDVVVLISHTGRTKNLVEMAQLARENDATVIAITSRDTPLAHEATLALLLDVPEDTDVYMPMVSR
IAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKGVVIPNSFDS
>Mature_290_residues
MNTLEKIQSHLELLSKSERKVAEVILASPQTAIHSSIATLARMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEDDSVASYTGKIFESVMASLDTVKANLDIAAINRAVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYF
DDIVMQRMGCMNSSEGDVVVLISHTGRTKNLVEMAQLARENDATVIAITSRDTPLAHEATLALLLDVPEDTDVYMPMVSR
IAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKGVVIPNSFDS

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=283, Percent_Identity=84.0989399293286, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI87082369, Length=240, Percent_Identity=25, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788767, Length=262, Percent_Identity=27.4809160305344, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082130, Length=215, Percent_Identity=30.2325581395349, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31994; Mature: 31994

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLEKIQSHLELLSKSERKVAEVILASPQTAIHSSIATLARMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVNRNVEEDDSVASYTGKIFESVMASLDTVKANLDIAAINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYFDDIVMQRMGCMNSSEGDVVV
HHHHHHHHHHHEEEECCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCCCEEE
LISHTGRTKNLVEMAQLARENDATVIAITSRDTPLAHEATLALLLDVPEDTDVYMPMVSR
EEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHEEEEEEECCCCCCHHHHHHHH
IAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKGVVIPNSFDS
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCC
>Mature Secondary Structure
MNTLEKIQSHLELLSKSERKVAEVILASPQTAIHSSIATLARMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVNRNVEEDDSVASYTGKIFESVMASLDTVKANLDIAAINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYFDDIVMQRMGCMNSSEGDVVV
HHHHHHHHHHHEEEECCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCCCEEE
LISHTGRTKNLVEMAQLARENDATVIAITSRDTPLAHEATLALLLDVPEDTDVYMPMVSR
EEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHEEEEEEECCCCCCHHHHHHHH
IAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKGVVIPNSFDS
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]