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The map label for this gene is ttcA [H]

Identifier: 157370847

GI number: 157370847

Start: 2870353

End: 2871285

Strand: Direct

Name: ttcA [H]

Synonym: Spro_2607

Alternate gene names: 157370847

Gene position: 2870353-2871285 (Clockwise)

Preceding gene: 157370846

Following gene: 157370848

Centisome position: 52.68

GC content: 54.56

Gene sequence:

>933_bases
ATGTCAGAACAACAAACAGTTAGTCAAAAAGAGCAGTACAATCTGAACAAATTGCAAAAGCGCCTGCGTCGTAACGTGGG
TCAGGCGATCGCCGATTTCAACATGATTGAGGAAGGCGACCGCATCATGGTTTGCCTGTCCGGCGGCAAAGACAGCTACA
CCATGCTGGAGATTTTGCGCAACCTGCAGCAAAGCGCCCCGGTCAATTTCTCACTGGTTGCGGTCAACCTCGATCAGAAA
CAACCCGGTTTCCCCGAGCATATTCTGCCGGCCTATCTGGAAAGCCTGGGGGTGGAATACCAGATTGTTGAGGAAAACAC
CTACAGCATCGTCAAGGACAAGATCCCTGAGGGCAAAACCACCTGCTCACTGTGTTCACGCCTGCGCCGCGGCATTCTTT
ACCGCACCGCTACCGAGCTGGGGGCCACCAAAATTGCCCTTGGCCACCACCGCGACGATATTCTGCAGACACTGTTCCTC
AACATGTTCTACGGCGGCAAGCTGAAAGGCATGCCACCCAAGCTGATGAGCGACGATGGCAAACACGTGGTTATTCGCCC
GCTGGCTTACTGCCGTGAAAAAGACATCGAACGGTTCTCGGTCGCCAAAGGCTTCCCGATTATCCCGTGCAACCTGTGCG
GCTCGCAGCCCAACCTGCAACGCCAGGTGATTGGCGACATGCTGCGCGACTGGGATAAACGTTATCCGGGCCGGCTGGAA
ACCATGTTCAGCGCGATGCAGAACGTAGTGCCTTCGCACCTGAGTGACTACAACCTTTTTGATTTCAAAGGGATTCACCA
CGGCAGCGAAGTGGTTGACGGTGGCGATCTGGCCTTTGACCGTGAAGATATTCCAATGCAGCCGATCGGCTGGCAACCGG
AAGATGCGGATGATGCCGCCCCAGTGCGTTTAGACGTTCTCGAAATCAAGTAA

Upstream 100 bases:

>100_bases
AGCGGATGGATGAAATACCCAAGCAGCCCATAGAATGCTAAACTCGCTGCCTAAAACTTTATGCCCATAGTGCCCCCAAT
TGAGAACGAGCACGATTTAA

Downstream 100 bases:

>100_bases
GTCGTTATTCCGCCCGCACGCTGTGGGCGGAAATTTCCCTTCATCAGTTTTCGATCCCGCTCGCAATTTCAGCAGAATTC
ATCGGACAGTGCCGTTTTTA

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSEQQTVSQKEQYNLNKLQKRLRRNVGQAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPVNFSLVAVNLDQK
QPGFPEHILPAYLESLGVEYQIVEENTYSIVKDKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFL
NMFYGGKLKGMPPKLMSDDGKHVVIRPLAYCREKDIERFSVAKGFPIIPCNLCGSQPNLQRQVIGDMLRDWDKRYPGRLE
TMFSAMQNVVPSHLSDYNLFDFKGIHHGSEVVDGGDLAFDREDIPMQPIGWQPEDADDAAPVRLDVLEIK

Sequences:

>Translated_310_residues
MSEQQTVSQKEQYNLNKLQKRLRRNVGQAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPVNFSLVAVNLDQK
QPGFPEHILPAYLESLGVEYQIVEENTYSIVKDKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFL
NMFYGGKLKGMPPKLMSDDGKHVVIRPLAYCREKDIERFSVAKGFPIIPCNLCGSQPNLQRQVIGDMLRDWDKRYPGRLE
TMFSAMQNVVPSHLSDYNLFDFKGIHHGSEVVDGGDLAFDREDIPMQPIGWQPEDADDAAPVRLDVLEIK
>Mature_309_residues
SEQQTVSQKEQYNLNKLQKRLRRNVGQAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPVNFSLVAVNLDQKQ
PGFPEHILPAYLESLGVEYQIVEENTYSIVKDKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLN
MFYGGKLKGMPPKLMSDDGKHVVIRPLAYCREKDIERFSVAKGFPIIPCNLCGSQPNLQRQVIGDMLRDWDKRYPGRLET
MFSAMQNVVPSHLSDYNLFDFKGIHHGSEVVDGGDLAFDREDIPMQPIGWQPEDADDAAPVRLDVLEIK

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=311, Percent_Identity=86.8167202572347, Blast_Score=573, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI193211090, Length=270, Percent_Identity=28.8888888888889, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540090, Length=222, Percent_Identity=27.4774774774775, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24651972, Length=222, Percent_Identity=26.5765765765766, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 35117; Mature: 34986

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQQTVSQKEQYNLNKLQKRLRRNVGQAIADFNMIEEGDRIMVCLSGGKDSYTMLEILR
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHH
NLQQSAPVNFSLVAVNLDQKQPGFPEHILPAYLESLGVEYQIVEENTYSIVKDKIPEGKT
HHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCH
TCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKLKGMPPKLMSDDG
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCC
KHVVIRPLAYCREKDIERFSVAKGFPIIPCNLCGSQPNLQRQVIGDMLRDWDKRYPGRLE
CEEEEHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
TMFSAMQNVVPSHLSDYNLFDFKGIHHGSEVVDGGDLAFDREDIPMQPIGWQPEDADDAA
HHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCC
PVRLDVLEIK
CEEEEEEEEC
>Mature Secondary Structure 
SEQQTVSQKEQYNLNKLQKRLRRNVGQAIADFNMIEEGDRIMVCLSGGKDSYTMLEILR
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHH
NLQQSAPVNFSLVAVNLDQKQPGFPEHILPAYLESLGVEYQIVEENTYSIVKDKIPEGKT
HHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCH
TCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKLKGMPPKLMSDDG
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCC
KHVVIRPLAYCREKDIERFSVAKGFPIIPCNLCGSQPNLQRQVIGDMLRDWDKRYPGRLE
CEEEEHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
TMFSAMQNVVPSHLSDYNLFDFKGIHHGSEVVDGGDLAFDREDIPMQPIGWQPEDADDAA
HHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCC
PVRLDVLEIK
CEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA