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The map label for this gene is umuC [H]

Identifier: 157370846

GI number: 157370846

Start: 2868957

End: 2870225

Strand: Direct

Name: umuC [H]

Synonym: Spro_2606

Alternate gene names: 157370846

Gene position: 2868957-2870225 (Clockwise)

Preceding gene: 157370845

Following gene: 157370847

Centisome position: 52.65

GC content: 54.85

Gene sequence:

>1269_bases
ATGTACGCCCTGGCCGATGTAAACAACTTCTATGCAAGTTGTGAAACGCTGTGGCGTCCGGATCTGCGTGGCCGCCCGAT
TGTTGTTCTGTCGAACAACGACGGCTGCGTGGTGGCACAGAGCAAAGAGGCAAAGGCCCTGGGCCTGAAAACAGGCGCGC
CCTATTTCAAAATAAAACACGACTTTGAGCGTGCCGGGGGTATCGCATTCAGCAGCAACTACGAGCTGTACGCCGATATG
TCGATGCGAGTGATGGCCGTGCTCGAAGAAATGGCACCGCGGACCGAAATGTACTCTATCGACGAAAGCTTTCTGGAGCT
TACCGGGGTACAAAATTGTGTCGATTTGGCCACCTTTGGGCACCAGGTTCGCGCCCGCGTTTTGCGATGCACCGGCCTCA
CCGTCGGCGTCGGTATTGCCCAGACCAAGACGCTGGCAAAGTTGGCGAACTACGCGGCGAAAAAATGGAGTCAGACCCAA
GGCGTGGTTGACCTTTCCAACCAGGAGCGGCAGCGAAAACTAATGGATAAAGTACCGGTAGCAGAAGTCTGGGGCATCGG
GCGGCGCATAACCAAAGAATTGCAAAATATGGGGATCAAAAGCGCACTGCAGCTGGCGGATGCAAGCACCACGATGATCC
GCAAGCATTTCAGCGTGGTGGTTGAACGCACGGTGCGTGAACTGCGTGGTGAACCCTGTTTGTCACTTGAGGAGTTTGCC
CCCACCAAACAGCAAATCATTTGCAGCAGATCCTTTGGCGAACGCGTCACTGAATACCAGGATATGCATCAGGCGATCTG
CATGCACGCTTCCCGCGCGGCAGAAAAACTGCGTGCAGAACACCAGTATTGCCGGAATATCAATGCATGGGTTAAAACCA
GCCCCTTCTCGGCCAATGAAAAGTATTACGGCAACACCGCGAGCATCAGGCTCAATACGCCGACGCAAGATACGCGCGAC
ATCATCGCCGCTGCGATTCGATGCCTTGATAAGATATGGCAGCCCGGCCACCGTTATCTAAAAGCCGGCGTTATGCTGCA
GGACTTTTACTCGCAAGGCGTCGCTCAGTTGGACCTGTTCGATGAGTATCAGCCACGGCCTAACAGCGCACGCTTAATGG
CCGCGTTGGATAAAATCAATCAGTCCGGGCATGCCGGGATCTGGTTTGCCGGGCAAGGAAACCAACAGACATGGTCGATG
AAACGTGAGTTTCTCTCTCCCGCTTACACCACGCGGGTGGCAGATTTGCCACGTGCCCGCGTGTACTGA

Upstream 100 bases:

>100_bases
AGCCGATGAACCCGACATTCAGGCCGATACCGCTCCCGGATGATGGTGCTGAACTGGACATTGTCGGCGTGGTGGTTTCA
ACCATCACCAGGCTGAAATA

Downstream 100 bases:

>100_bases
GGCAAGCAAACCGCATTTGCTATCCGGAGCGGATGGATGAAATACCCAAGCAGCCCATAGAATGCTAAACTCGCTGCCTA
AAACTTTATGCCCATAGTGC

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MYALADVNNFYASCETLWRPDLRGRPIVVLSNNDGCVVAQSKEAKALGLKTGAPYFKIKHDFERAGGIAFSSNYELYADM
SMRVMAVLEEMAPRTEMYSIDESFLELTGVQNCVDLATFGHQVRARVLRCTGLTVGVGIAQTKTLAKLANYAAKKWSQTQ
GVVDLSNQERQRKLMDKVPVAEVWGIGRRITKELQNMGIKSALQLADASTTMIRKHFSVVVERTVRELRGEPCLSLEEFA
PTKQQIICSRSFGERVTEYQDMHQAICMHASRAAEKLRAEHQYCRNINAWVKTSPFSANEKYYGNTASIRLNTPTQDTRD
IIAAAIRCLDKIWQPGHRYLKAGVMLQDFYSQGVAQLDLFDEYQPRPNSARLMAALDKINQSGHAGIWFAGQGNQQTWSM
KREFLSPAYTTRVADLPRARVY

Sequences:

>Translated_422_residues
MYALADVNNFYASCETLWRPDLRGRPIVVLSNNDGCVVAQSKEAKALGLKTGAPYFKIKHDFERAGGIAFSSNYELYADM
SMRVMAVLEEMAPRTEMYSIDESFLELTGVQNCVDLATFGHQVRARVLRCTGLTVGVGIAQTKTLAKLANYAAKKWSQTQ
GVVDLSNQERQRKLMDKVPVAEVWGIGRRITKELQNMGIKSALQLADASTTMIRKHFSVVVERTVRELRGEPCLSLEEFA
PTKQQIICSRSFGERVTEYQDMHQAICMHASRAAEKLRAEHQYCRNINAWVKTSPFSANEKYYGNTASIRLNTPTQDTRD
IIAAAIRCLDKIWQPGHRYLKAGVMLQDFYSQGVAQLDLFDEYQPRPNSARLMAALDKINQSGHAGIWFAGQGNQQTWSM
KREFLSPAYTTRVADLPRARVY
>Mature_422_residues
MYALADVNNFYASCETLWRPDLRGRPIVVLSNNDGCVVAQSKEAKALGLKTGAPYFKIKHDFERAGGIAFSSNYELYADM
SMRVMAVLEEMAPRTEMYSIDESFLELTGVQNCVDLATFGHQVRARVLRCTGLTVGVGIAQTKTLAKLANYAAKKWSQTQ
GVVDLSNQERQRKLMDKVPVAEVWGIGRRITKELQNMGIKSALQLADASTTMIRKHFSVVVERTVRELRGEPCLSLEEFA
PTKQQIICSRSFGERVTEYQDMHQAICMHASRAAEKLRAEHQYCRNINAWVKTSPFSANEKYYGNTASIRLNTPTQDTRD
IIAAAIRCLDKIWQPGHRYLKAGVMLQDFYSQGVAQLDLFDEYQPRPNSARLMAALDKINQSGHAGIWFAGQGNQQTWSM
KREFLSPAYTTRVADLPRARVY

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=422, Percent_Identity=68.7203791469194, Blast_Score=607, Evalue=1e-175,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 47576; Mature: 47576

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYALADVNNFYASCETLWRPDLRGRPIVVLSNNDGCVVAQSKEAKALGLKTGAPYFKIKH
CCEECCHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCCCEEECCCCCCCEEEEC
DFERAGGIAFSSNYELYADMSMRVMAVLEEMAPRTEMYSIDESFLELTGVQNCVDLATFG
HHHHHCCEEEECCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HQVRARVLRCTGLTVGVGIAQTKTLAKLANYAAKKWSQTQGVVDLSNQERQRKLMDKVPV
HHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHCCH
AEVWGIGRRITKELQNMGIKSALQLADASTTMIRKHFSVVVERTVRELRGEPCLSLEEFA
HHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHC
PTKQQIICSRSFGERVTEYQDMHQAICMHASRAAEKLRAEHQYCRNINAWVKTSPFSANE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCC
KYYGNTASIRLNTPTQDTRDIIAAAIRCLDKIWQPGHRYLKAGVMLQDFYSQGVAQLDLF
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEHHH
DEYQPRPNSARLMAALDKINQSGHAGIWFAGQGNQQTWSMKREFLSPAYTTRVADLPRAR
HHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHHCCCCCC
VY
CC
>Mature Secondary Structure
MYALADVNNFYASCETLWRPDLRGRPIVVLSNNDGCVVAQSKEAKALGLKTGAPYFKIKH
CCEECCHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCCCEEECCCCCCCEEEEC
DFERAGGIAFSSNYELYADMSMRVMAVLEEMAPRTEMYSIDESFLELTGVQNCVDLATFG
HHHHHCCEEEECCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HQVRARVLRCTGLTVGVGIAQTKTLAKLANYAAKKWSQTQGVVDLSNQERQRKLMDKVPV
HHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHCCH
AEVWGIGRRITKELQNMGIKSALQLADASTTMIRKHFSVVVERTVRELRGEPCLSLEEFA
HHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHC
PTKQQIICSRSFGERVTEYQDMHQAICMHASRAAEKLRAEHQYCRNINAWVKTSPFSANE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCC
KYYGNTASIRLNTPTQDTRDIIAAAIRCLDKIWQPGHRYLKAGVMLQDFYSQGVAQLDLF
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEHHH
DEYQPRPNSARLMAALDKINQSGHAGIWFAGQGNQQTWSMKREFLSPAYTTRVADLPRAR
HHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHHCCCCCC
VY
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]