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The map label for this gene is hisC

Identifier: 157369857

GI number: 157369857

Start: 1768110

End: 1769198

Strand: Reverse

Name: hisC

Synonym: Spro_1614

Alternate gene names: 157369857

Gene position: 1769198-1768110 (Counterclockwise)

Preceding gene: 157369858

Following gene: 157369856

Centisome position: 32.47

GC content: 58.77

Gene sequence:

>1089_bases
ATGAGCATTGAAAATCTGGCACGCACCAACGTTCGCGATCTGACCCCTTATCAGTCGGCACGCCGCCTGGGTGGCAACGG
CGACGTGTGGCTGAACGCCAACGAATACCCGATCGCCCCAGAGTTCCAACTGACCGCTCAAACCTTTAACCGTTACCCGG
AGTGCCAACCGGCACTGGTGATCGAACGCTACGCCGAGTATGCCGGGGTTAAAAAGGAACAGGTGCTGGTCAGCCGTGGG
GCAGACGAAGGTATCGAACTGCTGATCCGCGCATTCTGCGAGCCGGGAAAAGACGCCATCCTGTTCTGCCCGCCGACCTA
CGGTATGTATGCCGTCAGCGCCGAAACCTTTGGCGTGGAGCGTCGTACCGTGGCGGCCAAACAGGACTGGCAGCTGGATT
TGCCGGCCATCGCCGACAGCCTGGACAACGTAAAACTGATTTACGTCTGCAGCCCCAACAACCCGACGGGTAACCTGATC
GATGCCAACGATCTGCGCAGCCTGCTGGAAATGGCCAAGGGCAAGGCAATCGTTGCGGTCGACGAGGCCTATATTGAATT
CTGCCCACAGGCAAGCGTCGCCGGCTGGCTAAATGACTACCCGCACCTGGCTATCTTGCGCACCCTGTCCAAGGCCTTTG
CGCTGGCTGGGCTGCGCTGCGGTTTTACCCTCGGCAACGAAGACTTGATCGCTCTGCTGCTGAAGGTGATAGCCCCTTAC
CCGCTCTCCACTCCGGTCGCCGATATCGCCGCCCAGGCGCTCAGCACCGAGGGGATCCGCATCATGCGCCAACGGGTTAC
CGAGATTGCTGCCAACCGTAGTTGGCTGCTGCAGGCGCTGCAAAACTGCGCCTGCGTTGAACAGGTTTTCACCAGCGACA
GCAATTACCTGCTGGCACGATTCACTGCCTCCAGTAATGTGTTTAAAACCTTGTGGGATCAGGGCATCATCTTAAGAGAC
CAAAATAAACAACCGGGGTTATCCGGCTGCCTGCGCATCACCATAGGCACCCGTGAAGAATGCCAGCGCGTGGTTGATGC
GCTGTCTGCCCTGCCCGGTGCAACCAAGACTCGCCAGGAGCCAATGTGA

Upstream 100 bases:

>100_bases
TGAACCTGGCCGCCACCATTGAAACCCTGGCCGCCGCCGAGCAGTTGATTGCCCACAAAAACGCCGTGACCCTGCGCGTT
GCCGCCCTGAAGGAGCAAGC

Downstream 100 bases:

>100_bases
GCCAGAAATTCCTCTTTATTGACCGTGACGGCACGCTGATTGCTGAACCACCAGAAGATTTCCAGGTCGACCGCCTGGAT
AAACTGGCGCTGGAGCCGGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSIENLARTNVRDLTPYQSARRLGGNGDVWLNANEYPIAPEFQLTAQTFNRYPECQPALVIERYAEYAGVKKEQVLVSRG
ADEGIELLIRAFCEPGKDAILFCPPTYGMYAVSAETFGVERRTVAAKQDWQLDLPAIADSLDNVKLIYVCSPNNPTGNLI
DANDLRSLLEMAKGKAIVAVDEAYIEFCPQASVAGWLNDYPHLAILRTLSKAFALAGLRCGFTLGNEDLIALLLKVIAPY
PLSTPVADIAAQALSTEGIRIMRQRVTEIAANRSWLLQALQNCACVEQVFTSDSNYLLARFTASSNVFKTLWDQGIILRD
QNKQPGLSGCLRITIGTREECQRVVDALSALPGATKTRQEPM

Sequences:

>Translated_362_residues
MSIENLARTNVRDLTPYQSARRLGGNGDVWLNANEYPIAPEFQLTAQTFNRYPECQPALVIERYAEYAGVKKEQVLVSRG
ADEGIELLIRAFCEPGKDAILFCPPTYGMYAVSAETFGVERRTVAAKQDWQLDLPAIADSLDNVKLIYVCSPNNPTGNLI
DANDLRSLLEMAKGKAIVAVDEAYIEFCPQASVAGWLNDYPHLAILRTLSKAFALAGLRCGFTLGNEDLIALLLKVIAPY
PLSTPVADIAAQALSTEGIRIMRQRVTEIAANRSWLLQALQNCACVEQVFTSDSNYLLARFTASSNVFKTLWDQGIILRD
QNKQPGLSGCLRITIGTREECQRVVDALSALPGATKTRQEPM
>Mature_361_residues
SIENLARTNVRDLTPYQSARRLGGNGDVWLNANEYPIAPEFQLTAQTFNRYPECQPALVIERYAEYAGVKKEQVLVSRGA
DEGIELLIRAFCEPGKDAILFCPPTYGMYAVSAETFGVERRTVAAKQDWQLDLPAIADSLDNVKLIYVCSPNNPTGNLID
ANDLRSLLEMAKGKAIVAVDEAYIEFCPQASVAGWLNDYPHLAILRTLSKAFALAGLRCGFTLGNEDLIALLLKVIAPYP
LSTPVADIAAQALSTEGIRIMRQRVTEIAANRSWLLQALQNCACVEQVFTSDSNYLLARFTASSNVFKTLWDQGIILRDQ
NKQPGLSGCLRITIGTREECQRVVDALSALPGATKTRQEPM

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=350, Percent_Identity=77.4285714285714, Blast_Score=569, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6322075, Length=373, Percent_Identity=33.2439678284182, Blast_Score=176, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_SERP5 (A8GC78)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477846.1
- ProteinModelPortal:   A8GC78
- SMR:   A8GC78
- STRING:   A8GC78
- GeneID:   5603826
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1614
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   FKTLWDQ
- ProtClustDB:   PRK01688
- BioCyc:   SPRO399741:SPRO_1614-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39866; Mature: 39735

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIENLARTNVRDLTPYQSARRLGGNGDVWLNANEYPIAPEFQLTAQTFNRYPECQPALV
CCHHHHHHCCCHHCCCHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHH
IERYAEYAGVKKEQVLVSRGADEGIELLIRAFCEPGKDAILFCPPTYGMYAVSAETFGVE
HHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEHHHHCCC
RRTVAAKQDWQLDLPAIADSLDNVKLIYVCSPNNPTGNLIDANDLRSLLEMAKGKAIVAV
HHHECCCCCCCEECHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEE
DEAYIEFCPQASVAGWLNDYPHLAILRTLSKAFALAGLRCGFTLGNEDLIALLLKVIAPY
CHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHCCC
PLSTPVADIAAQALSTEGIRIMRQRVTEIAANRSWLLQALQNCACVEQVFTSDSNYLLAR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
FTASSNVFKTLWDQGIILRDQNKQPGLSGCLRITIGTREECQRVVDALSALPGATKTRQE
EECCCHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCC
PM
CC
>Mature Secondary Structure 
SIENLARTNVRDLTPYQSARRLGGNGDVWLNANEYPIAPEFQLTAQTFNRYPECQPALV
CHHHHHHCCCHHCCCHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHH
IERYAEYAGVKKEQVLVSRGADEGIELLIRAFCEPGKDAILFCPPTYGMYAVSAETFGVE
HHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEHHHHCCC
RRTVAAKQDWQLDLPAIADSLDNVKLIYVCSPNNPTGNLIDANDLRSLLEMAKGKAIVAV
HHHECCCCCCCEECHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEE
DEAYIEFCPQASVAGWLNDYPHLAILRTLSKAFALAGLRCGFTLGNEDLIALLLKVIAPY
CHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHCCC
PLSTPVADIAAQALSTEGIRIMRQRVTEIAANRSWLLQALQNCACVEQVFTSDSNYLLAR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
FTASSNVFKTLWDQGIILRDQNKQPGLSGCLRITIGTREECQRVVDALSALPGATKTRQE
EECCCHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCC
PM
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA