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The map label for this gene is hisD [H]

Identifier: 157369858

GI number: 157369858

Start: 1769195

End: 1770502

Strand: Reverse

Name: hisD [H]

Synonym: Spro_1615

Alternate gene names: 157369858

Gene position: 1770502-1769195 (Counterclockwise)

Preceding gene: 157369859

Following gene: 157369857

Centisome position: 32.49

GC content: 60.55

Gene sequence:

>1308_bases
ATGTCGAACTTCAATACTCTGGTCAACTGGGCAGACTGCAGCGCCGAACAGCGCACGGCACTGCTGATGCGTCCGGCGAT
CTCCGCCTCGGACAGCATCAGCCGCACGGTGAGCGAAATCCTCGACAACGTGAAGGCCAATGGCGATCAGGCGCTGCGCG
AATACAGCGCTAAATTTGATAAAACCGAAGTTGGCGCACTGCGCGTCACCGCAGAGCAAATAACGGCTGCCAGCGCGCGT
CTGGGCGATGAGATCAAGCAGGCAATGGCAATTGCAGTCGCCAACGTGGAAACCTTCCACAATGCGCAAAAACTGCCGCC
GGTTGATGTGGAAACCCAGCCGGGTGTGCGTTGTCAGCAGGTAACCCGTCCGATCGACTCGGTTGGGCTATATATTCCAG
GCGGTTCTGCTCCGCTATTTTCTACGGTGTTGATGCTGGCGACACCGGCACGCATCGCCGGTTGCCGCCGCGTAGTGCTG
TGTTCACCGCCGCCGATTGCCGATGAGATACTGTATGCCGCACAACTGTGTGGAGTGGAAGAGGTGTTTCAGGTTGGCGG
TGCGCAGGCGATCGCCGCTATGGCATTCGGTACCGACTCCGTACCGCGCGTGGCAAAAATCTTCGGGCCGGGCAATGCCT
TTGTCACCGAAGCCAAACGCCAGATCAGCCAACGACTGGACGGTGCCGCCATCGATATGCCGGCCGGCCCTTCCGAAGTG
CTGGTGATCGCCGACGCCGGTGCCACTCCGGCATTCGTCGCCTCGGATCTGCTGTCACAGGCGGAGCACGGCCCGGACTC
GCAGGTGATTTTGTTGACACCGGAAGCCGCGATGGCGCAGGCGGTACGCGATGCCGTAGAACAGCAACTGGCACAATTAC
CCCGCGCCGAAACTGCACGTCAGGCGCTGGCCAGTAGCCGACTGATTGTCACCAAAGATTTGGCCGAGTGCGTGGCCATC
AGCAATCAGTATGGCCCGGAACACCTGATCATTCAGACCCGCGACGCCCGCGCTCTGGTCGACAGCATCACCAGCGCCGG
TTCGGTGTTTCTTGGCGACTGGTCACCGGAGTCTGCCGGTGACTATGCGTCCGGCACCAACCACGTGCTGCCAACCTATG
GTTACACCGCCACCTGCTCCAGTTTGGGGCTGGCGGACTTCCAAAAACGCATGACGGTACAAGAGTTGACGCCGCAGGGC
TTTATGAACCTGGCCGCCACCATTGAAACCCTGGCCGCCGCCGAGCAGTTGATTGCCCACAAAAACGCCGTGACCCTGCG
CGTTGCCGCCCTGAAGGAGCAAGCATGA

Upstream 100 bases:

>100_bases
AGTAGCGAAACCCTGTTCTGGGAAACCATGGAAAAACTGAAAGCGCTCGGTGCCAGCTCGATTCTGGTATTGCCTATTGA
GAAGATGATGGAGTAACGCC

Downstream 100 bases:

>100_bases
GCATTGAAAATCTGGCACGCACCAACGTTCGCGATCTGACCCCTTATCAGTCGGCACGCCGCCTGGGTGGCAACGGCGAC
GTGTGGCTGAACGCCAACGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSNFNTLVNWADCSAEQRTALLMRPAISASDSISRTVSEILDNVKANGDQALREYSAKFDKTEVGALRVTAEQITAASAR
LGDEIKQAMAIAVANVETFHNAQKLPPVDVETQPGVRCQQVTRPIDSVGLYIPGGSAPLFSTVLMLATPARIAGCRRVVL
CSPPPIADEILYAAQLCGVEEVFQVGGAQAIAAMAFGTDSVPRVAKIFGPGNAFVTEAKRQISQRLDGAAIDMPAGPSEV
LVIADAGATPAFVASDLLSQAEHGPDSQVILLTPEAAMAQAVRDAVEQQLAQLPRAETARQALASSRLIVTKDLAECVAI
SNQYGPEHLIIQTRDARALVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELTPQG
FMNLAATIETLAAAEQLIAHKNAVTLRVAALKEQA

Sequences:

>Translated_435_residues
MSNFNTLVNWADCSAEQRTALLMRPAISASDSISRTVSEILDNVKANGDQALREYSAKFDKTEVGALRVTAEQITAASAR
LGDEIKQAMAIAVANVETFHNAQKLPPVDVETQPGVRCQQVTRPIDSVGLYIPGGSAPLFSTVLMLATPARIAGCRRVVL
CSPPPIADEILYAAQLCGVEEVFQVGGAQAIAAMAFGTDSVPRVAKIFGPGNAFVTEAKRQISQRLDGAAIDMPAGPSEV
LVIADAGATPAFVASDLLSQAEHGPDSQVILLTPEAAMAQAVRDAVEQQLAQLPRAETARQALASSRLIVTKDLAECVAI
SNQYGPEHLIIQTRDARALVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELTPQG
FMNLAATIETLAAAEQLIAHKNAVTLRVAALKEQA
>Mature_434_residues
SNFNTLVNWADCSAEQRTALLMRPAISASDSISRTVSEILDNVKANGDQALREYSAKFDKTEVGALRVTAEQITAASARL
GDEIKQAMAIAVANVETFHNAQKLPPVDVETQPGVRCQQVTRPIDSVGLYIPGGSAPLFSTVLMLATPARIAGCRRVVLC
SPPPIADEILYAAQLCGVEEVFQVGGAQAIAAMAFGTDSVPRVAKIFGPGNAFVTEAKRQISQRLDGAAIDMPAGPSEVL
VIADAGATPAFVASDLLSQAEHGPDSQVILLTPEAAMAQAVRDAVEQQLAQLPRAETARQALASSRLIVTKDLAECVAIS
NQYGPEHLIIQTRDARALVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELTPQGF
MNLAATIETLAAAEQLIAHKNAVTLRVAALKEQA

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=433, Percent_Identity=84.526558891455, Blast_Score=760, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319819, Length=419, Percent_Identity=46.3007159904535, Blast_Score=368, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45886; Mature: 45754

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFNTLVNWADCSAEQRTALLMRPAISASDSISRTVSEILDNVKANGDQALREYSAKFD
CCCCHHHEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
KTEVGALRVTAEQITAASARLGDEIKQAMAIAVANVETFHNAQKLPPVDVETQPGVRCQQ
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
VTRPIDSVGLYIPGGSAPLFSTVLMLATPARIAGCRRVVLCSPPPIADEILYAAQLCGVE
HHCCHHHCEEEECCCCCHHHHHHHHHHCCHHHHCCCEEEEECCCCHHHHHHHHHHHCCHH
EVFQVGGAQAIAAMAFGTDSVPRVAKIFGPGNAFVTEAKRQISQRLDGAAIDMPAGPSEV
HHHHCCCHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCE
LVIADAGATPAFVASDLLSQAEHGPDSQVILLTPEAAMAQAVRDAVEQQLAQLPRAETAR
EEEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHH
QALASSRLIVTKDLAECVAISNQYGPEHLIIQTRDARALVDSITSAGSVFLGDWSPESAG
HHHHHCCEEEHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHCCCCEEEECCCCCCCC
DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELTPQGFMNLAATIETLAAAEQLIAH
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
KNAVTLRVAALKEQA
CCCEEEEEEHHCCCC
>Mature Secondary Structure 
SNFNTLVNWADCSAEQRTALLMRPAISASDSISRTVSEILDNVKANGDQALREYSAKFD
CCCHHHEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
KTEVGALRVTAEQITAASARLGDEIKQAMAIAVANVETFHNAQKLPPVDVETQPGVRCQQ
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
VTRPIDSVGLYIPGGSAPLFSTVLMLATPARIAGCRRVVLCSPPPIADEILYAAQLCGVE
HHCCHHHCEEEECCCCCHHHHHHHHHHCCHHHHCCCEEEEECCCCHHHHHHHHHHHCCHH
EVFQVGGAQAIAAMAFGTDSVPRVAKIFGPGNAFVTEAKRQISQRLDGAAIDMPAGPSEV
HHHHCCCHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCE
LVIADAGATPAFVASDLLSQAEHGPDSQVILLTPEAAMAQAVRDAVEQQLAQLPRAETAR
EEEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHH
QALASSRLIVTKDLAECVAISNQYGPEHLIIQTRDARALVDSITSAGSVFLGDWSPESAG
HHHHHCCEEEHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHCCCCEEEECCCCCCCC
DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELTPQGFMNLAATIETLAAAEQLIAH
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
KNAVTLRVAALKEQA
CCCEEEEEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10222209; 11206551; 11258796 [H]